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    ACCELERATED MIXED GAS INTEGRITY TESTING OF POROUS MATERIALS
    1.
    发明公开
    ACCELERATED MIXED GAS INTEGRITY TESTING OF POROUS MATERIALS 有权
    百时美施贵宝

    公开(公告)号：EP2668489A4

    公开(公告)日：2017-05-10

    申请号：EP12738846

    申请日：2012-01-24

    申请人： EMD MILLIPORE CORP

    发明人： HOA JIBIN ,  GIGLIA SALVATORE ,  JOENS MICHAEL ,  TUCELLI RONALD

    IPC分类号： G01N15/08 ,  B01D65/10 ,  G01N33/44

    CPC分类号： B01D46/2411 ,  B01D46/543 ,  B01D65/102 ,  G01N15/082 ,  G01N2015/084

    摘要： The invention relates to accelerated mixed gas integrity testing methods, devices, and systems for integrity testing wetted single and multi-layered porous materials, whereby the testing method is non-destructive to the porous materials being tested. The accelerated mixed gas integrity test method includes one or more of the following components: i) a permeate side gas purge component; ii) a permeate side volume reduction component; and iii) a permeate side circulation component. The invention is directed towards reducing the length of time necessary to complete the integrity testing of single and multi layered porous materials, elements and membranes.

    摘要翻译： 本发明涉及加速混合气体完整性测试方法，装置和用于完整性测试湿单层和多层多孔材料的系统，由此该测试方法对被测试的多孔材料无破坏性。 加速混合气体完整性测试方法包括以下一个或多个组件：i）渗透侧气体吹扫组件; ii）渗透侧减容组分; 和iii）渗透侧循环组分。 本发明旨在减少完成单层和多层多孔材料，元件和膜的完整性测试所需的时间长度。

    DISPOSABLE DIRECT CAPTURE DEVICE
    2.
    发明公开
    DISPOSABLE DIRECT CAPTURE DEVICE 审中-公开
    一次性直接检测设备

    公开(公告)号：EP2951552A4

    公开(公告)日：2016-09-21

    申请号：EP13874031

    申请日：2013-12-13

    申请人： EMD MILLIPORE CORP

    发明人： CACACE BENJAMIN

    IPC分类号： G01N1/10 ,  C12N15/10 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N1/34 ,  B01J39/26 ,  B01J41/20 ,  B01J47/014 ,  B01J47/022 ,  B01J47/127 ,  B01L3/505 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/123 ,  C07K1/14 ,  C07K1/36 ,  G01N1/405

    摘要： The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.

    METHODS AND DEVICES USED FOR REDUNDANT STERILE FILTRATION
    3.
    发明公开
    METHODS AND DEVICES USED FOR REDUNDANT STERILE FILTRATION 审中-公开
    VERFAHREN UND VORRICHTUNGENFÜRREDUNDANTE STERILE FILTRATION

    公开(公告)号：EP2925420A4

    公开(公告)日：2016-09-21

    申请号：EP13859871

    申请日：2013-11-26

    申请人： EMD MILLIPORE CORP

    发明人： PERREAULT JEREMY ,  FOLEY SEAN ,  RAUTIO KEVIN

    IPC分类号： B01D25/26 ,  B01D61/14 ,  B01D61/18

    CPC分类号： B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

    摘要： Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

    摘要翻译： 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器的网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络设置有一个或多个投入物，用于将液体原料引入到流体工艺流中，以及一个或多个输出端口，用于将流体从流体工艺流中排出。 网络优选地是基本上封闭的网络，并且优选地是无菌的和/或无菌的。

    IMPROVED BIOMATERIAL FREEZING
    4.
    发明公开
    IMPROVED BIOMATERIAL FREEZING 审中-公开
    改进的生物材料冻结

    公开(公告)号：EP2387686A4

    公开(公告)日：2015-11-04

    申请号：EP10732002

    申请日：2010-01-12

    申请人： EMD MILLIPORE CORP

    发明人： BURKE AARON ,  FELO MICHAEL ,  PEREIRA BRIAN ,  NOUKAS ELIAS ,  WONG DENNIS

    IPC分类号： F17C5/00

    CPC分类号： F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

    摘要： The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

    CENTRIFUGAL FILTER
    7.
    发明公开
    CENTRIFUGAL FILTER 有权
    ZENTRIFUGALFILTER

    公开(公告)号：EP2192968A4

    公开(公告)日：2011-08-31

    申请号：EP08795626

    申请日：2008-08-27

    申请人： MILLIPORE CORP

    发明人： BONHOMME LOUIS ,  DOYLE JOHN ,  GREENIZEN KURT ,  GAGNE GEORGE ,  DEVIN SEAN ,  LOMBARD GERARD ,  SMITH VINCENT

    IPC分类号： B01D33/15

    CPC分类号： B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    摘要： The invention pertains to a filtration device (10), comprising a central jacket and first and second side panels interlocked together around said jacket, each of said side panels comprising a membrane (12A,12B) sealed thereto. The invention further pertains to a combination of said filtration device and a vial comprising an interior volume configured to receive said filtration device in a first orientation effective for concentrating sample in said sample chamber when subjected to a driving force, and in a second orientation effective for recovering concentrated sample when subjected to a driving force.

    摘要翻译： 本发明涉及一种过滤装置（10），其包括中心护套和围绕所述夹套互锁在一起的第一和第二侧板，每个所述侧板包括密封在其上的膜（12A，12B）。 本发明还涉及所述过滤装置和小瓶的组合，所述小瓶包括内部容积，所述内部容积被配置为在受到驱动力时有效地将样品浓缩在所述样品室中的第一取向中接收所述过滤装置，并且在第二取向 在受到驱动力的情况下回收浓缩样品。