公开(公告)号：EP0645048A1

公开(公告)日：1995-03-29

申请号：EP93915304.0

申请日：1993-06-08

申请人： MOLECULAR BIOQUEST, INC.

发明人： CHAGNON, Mark, S. ,  CARTER, Michelle, J. ,  FERRIS, John, R. ,  GRAY, Maria, A. ,  HAMILTON, Tracy, J. ,  RUDD, Edwin, A.

IPC分类号： G01N33 ,  A61K9 ,  A61K41 ,  A61K47 ,  A61K49 ,  A61N2 ,  B03C1 ,  C01G1 ,  C12N11 ,  H01F1

CPC分类号： A61K41/0052 ,  A61K9/1272 ,  A61K47/6923 ,  A61K49/1812 ,  A61K49/183 ,  A61K49/1839 ,  B03C1/01 ,  C12N11/14 ,  G01N33/54313 ,  G01N33/5434 ,  G01N33/551 ,  G01N33/554 ,  G01N2446/20 ,  G01N2446/80 ,  G01N2446/84 ,  G01N2446/90

摘要： Inorganic oxides of substantially uniform particle size distribution are prepared by contacting aqueous solutions of an inorganic salt and an inorganic base across a porous membrane (14) wherein the membrane contains a plurality of pores which allows for precipitation of a substantially mono-dispersed size inorganic oxide particles on one side of the membrane and precipitation of a salt of the corresponding base on a second side of the membrane (Fig. 1). The particles so prepared can be coated with an organo-metallic polymer having attached thereto an organic functionality to which a variety of organic and/or biological molecules can be coupled. Particles so coupled may be used for in vitro or in vivo systems involving separations steps or the directed movement of coupled molecules to particular sites, including immunological assays, other biological assays, biochemical or enzymatic reactions, affinity chromatographic purification, cell sorting and diagnostic and therapeutic uses. In a further embodiment, described herein are liposome compositions which comprise the substantially uniform size inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid (Fig. 2). Also disclosed are novel phenyl lipid compounds which serve as the vesicle forming lipid (Fig. 3). When the magnetic particles are electromagnetic wave-absorbing surface modified particles (Fig. 4), such particles provide for the preparation of liposome compositions which offer a method for the treatment of cancer, as well as infectious diseases.

公开(公告)号：EP0546939A1

公开(公告)日：1993-06-16

申请号：EP92403345.9

申请日：1992-12-09

申请人： MOLECULAR BIOQUEST, INC.

发明人： Chagnon, Mark S. ,  Ferris, John R. ,  Fiore, Barry L. ,  Carter, Michelle J. ,  Hamilton, Tracy J.

IPC分类号： A61K49/00 ,  A61K47/48

CPC分类号： A61K49/1821 ,  A61K47/6923 ,  A61K47/6941 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1854 ,  A61K49/1887 ,  Y10S428/90 ,  Y10T428/256 ,  Y10T428/26 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/24

摘要： Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo , biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

摘要翻译： 公开了共价耦合到化学反应性有机部分并随后一起反应以形成可生物降解的磁性微团簇的子域金属或金属氧化物颗粒。 磁性微团簇可用作NMR成像中的造影剂，用于生产适合用于诊断，体内递送和靶向药物的图像，如体内，用于在金属处理中游离金属离子螯合的可生物降解剂 驱动疾病

公开(公告)号：EP0542829B1

公开(公告)日：1994-04-27

申请号：EP91914374.3

申请日：1991-08-09

申请人： MOLECULAR BIOQUEST, INC.

发明人： CHAGNON, Mark, S. ,  HAMILTON, Tracy

IPC分类号： H01F1/00 ,  H01F1/36 ,  H01F1/11 ,  C01G49/08

CPC分类号： B82Y30/00 ,  A61K49/1818 ,  B03C1/01 ,  B82Y5/00 ,  B82Y25/00 ,  C01G49/08 ,  C01P2004/51 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/42 ,  H01F1/0054 ,  H01F1/11 ,  H01F1/445

摘要： A novel method for producing magnetic microparticles from metallocene is disclosed. The method involves combining an aqueous slurry of the metallocene and an aqueous slurry of a metal hydroxide and milling the slurries together. Fine magnetic particles are produced using the present method.