公开(公告)号：EP1708651A4

公开(公告)日：2011-11-02

申请号：EP05712509

申请日：2005-01-27

申请人： OSTEOTECH INC

发明人： KNAACK DAVID ,  DIEGMANN MICHELE ,  MANRIQUE ALBERT ,  BENHAM KEYVAN

IPC分类号： A61F2/28 ,  A61L27/36

CPC分类号： A61L27/3608 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61K31/728 ,  A61K35/32 ,  A61K38/55 ,  A61L27/365 ,  A61L27/3695 ,  A61L2430/02 ,  B33Y80/00 ,  A61K2300/00

摘要： A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.

公开(公告)号：EP2254649A1

公开(公告)日：2010-12-01

申请号：EP08873572.5

申请日：2008-12-24

申请人： Osteotech, Inc.,

发明人： WEI, Guobao ,  BEHNAM, Keyvan ,  FORSYTH, Nanette ,  WINTERBOTTOM, John ,  BEISSER, James ,  BOYCE, Todd, M. ,  ATTAWIA, Mohamed ,  RICHARDS, Cristy, J. ,  SHIMP, Lawrence

IPC分类号： A61M37/00

CPC分类号： A61M35/00

摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.

公开(公告)号：EP1494624B1

公开(公告)日：2010-06-30

申请号：EP03726166.6

申请日：2003-03-31

申请人： Osteotech, Inc.

发明人： MORRIS, John, W. ,  PETERSEN, Kenneth, C. ,  SHIMP, Lawrence, A. ,  DAUGHERTY, Mark, P.

IPC分类号： A61F2/28 ,  A01N1/00

CPC分类号： A61L27/3683 ,  A01N1/00 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2002/4645 ,  A61F2002/4649 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  A61L2430/40

摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.

公开(公告)号：EP1053032B1

公开(公告)日：2008-10-22

申请号：EP99905807.6

申请日：1999-02-05

申请人： Osteotech, Inc.

发明人： BOYCE, Todd, M. ,  MANRIQUE, Albert

IPC分类号： A61L27/00 ,  A61F2/28

CPC分类号： A61F2/4644 ,  A61B17/7062 ,  A61F2/28 ,  A61F2/2875 ,  A61F2/3094 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/2817 ,  A61F2002/2825 ,  A61F2002/2835 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30138 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30261 ,  A61F2002/30448 ,  A61F2002/30593 ,  A61F2002/30599 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/30957 ,  A61F2002/4649 ,  A61F2220/005 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0017 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0063 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3695 ,  A61L2430/02

摘要： The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into the bone implant material such as bone-growth inducing substances; and a method of manufacture.

公开(公告)号：EP1839622A2

公开(公告)日：2007-10-03

申请号：EP07014052.0

申请日：1997-09-15

申请人： Osteotech, Inc.,

发明人： Scarborough, Nelson L.

IPC分类号： A61F2/02 ,  A61L27/00 ,  A61F2/28 ,  A61F2/30 ,  A61B6/12

CPC分类号： A61B6/583 ,  A61B6/12 ,  A61B90/39 ,  A61F2/28 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30153 ,  A61F2002/30235 ,  A61F2002/30242 ,  A61F2002/30263 ,  A61F2002/30291 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0084 ,  A61F2230/0091 ,  A61F2250/0098 ,  A61F2310/00293 ,  A61F2310/00365

摘要： A surgical implant for surgical implantation in a body is fabricated from radiolucent material and possesses a resorbable particulate radiopaque marker arranged within the radiolucent material in a predetermined geometric pattern.

公开(公告)号：EP1589962A2

公开(公告)日：2005-11-02

申请号：EP04708211.0

申请日：2004-02-04

申请人： Osteotech, Inc.

发明人： KNAACK, David ,  WINTERBOTTOM, John, M. ,  KAES, David ,  BOYCE, Todd, M. ,  SHIMP, Lawrence, A.

IPC分类号： A61K31/26

CPC分类号： A61L27/3608 ,  A61L27/18 ,  A61L27/46 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/02 ,  C08G18/10 ,  C08G18/36 ,  C08G18/3878 ,  C08G18/3882 ,  C08G18/6484 ,  C08G18/73 ,  C08G18/771 ,  C08G18/798 ,  C08G2230/00 ,  C08L75/04

摘要： biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

公开(公告)号：EP1528938A2

公开(公告)日：2005-05-11

申请号：EP03785276.1

申请日：2003-08-12

申请人： Osteotech, Inc.

发明人： SHIMP, Lawrence, A. ,  WINTERBOTTOM, John, M. ,  BOYCE, Todd, M. ,  KNAACK, David

IPC分类号： A61L27/26

CPC分类号： A61L27/48 ,  A61L27/3608 ,  A61L27/46 ,  A61L2430/02 ,  C08L89/00

摘要： A method of producing a bone-polymer composite comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.

公开(公告)号：EP1341484A2

公开(公告)日：2003-09-10

申请号：EP01993238.3

申请日：2001-12-07

申请人： Osteotech, Inc., ,  Boyce, Todd M. ,  Shimp, Lawrence A.

发明人： BOYCE, Todd, M. ,  SHIMP, Lawrence, A.

IPC分类号： A61F2/08 ,  A61F2/28

CPC分类号： A61F2/08

摘要： An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.

公开(公告)号：EP1301222A2

公开(公告)日：2003-04-16

申请号：EP01953563.2

申请日：2001-07-19

申请人： Osteotech, Inc.,

发明人： EDWARDS, Jean, T. ,  SCARBOROUGH, Nelson, L. ,  MANRIQUE, Albert ,  BODEN, Scott, D.

IPC分类号： A61L27/36 ,  A61L31/00 ,  A61F2/28 ,  A61F2/44

CPC分类号： A61L27/3683 ,  A61B17/866 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4455 ,  A61F2/446 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2002/30113 ,  A61F2002/30153 ,  A61F2002/30156 ,  A61F2002/30205 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30261 ,  A61F2002/3085 ,  A61F2002/30957 ,  A61F2002/4649 ,  A61F2230/0006 ,  A61F2230/0019 ,  A61F2230/0023 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61L27/3608 ,  A61L27/365 ,  A61L31/005 ,  A61L2430/02

摘要： An osteoimplant is provided which comprises a shaped, coherent, three-dimensional porous matrix of elongate demineralized bone particles, wherein said matrix possesses a bulk density of lower than about 0.3 g/cm3. The osteoimplant of the invention is highly absorbent and sponge/like in nature. Also provided herein are a method of fabricating the osteoimplant herein and a method of repairing and/or treating bone utilizing the osteoimplant.

公开(公告)号：EP0732947B1

公开(公告)日：2002-03-06

申请号：EP95904299.5

申请日：1994-12-08

申请人： OSTEOTECH, INC.,

发明人： DOWD, Michael ,  DYKE, Denis, G.

IPC分类号： A61L27/00 ,  A61K35/32

CPC分类号： A61L27/3847 ,  A61F2/28 ,  A61F2002/2839 ,  A61F2002/30677 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695

摘要： Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.