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21 条记录 (耗时 0.011 秒)

    A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a crystal oscillator used therefor
    1.
    发明公开
    A method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution and a crystal oscillator used therefor 失效
    确定在离子溶液中含有的物质或离子的量的方法或非离子溶液和使用的晶体振荡器的方法

    公开(公告)号：EP0359473A3

    公开(公告)日：1990-11-22

    申请号：EP89309071.2

    申请日：1989-09-07

    申请人： SOGO PHARMACEUTICAL COMPANY LIMITED

    发明人： Okahata, Yoshio

    IPC分类号： G01N27/00

    CPC分类号： G01N29/036 ,  G01N33/84 ,  G01N2291/0256

    摘要： Disclosed are a method of determining the amount of the substances or ions contained in an ionic solution or a non-deionized solution by measuring the frequency of a one side barrier-covered crystal oscillator comprising a crystal oscillator 1,2a,2b, a barrier 6 to cover over one of the electrodes 2b of the crystal oscillator through a predetermined insulative space 5 so as to prevent the ionic solution or the non-deionized solution from permeating therethrough and an adsorption film 7 cast on the other electrode 2a of the crystal oscillator, in situ in the state that the one side barrier-covered crystal oscillator is dipped in the ionic solution or the non-deionized solution, and the one side barrier-­covered crystal oscillator used therefor.

    Method of detecting bitter or odor substances and apparatus therefor
    2.
    发明公开
    Method of detecting bitter or odor substances and apparatus therefor 失效
    用于检测苦味或臭味的物质的方法和装置。

    公开(公告)号：EP0282332A2

    公开(公告)日：1988-09-14

    申请号：EP88302154.5

    申请日：1988-03-11

    申请人： Sogo Pharmaceutical Company Limited

    发明人： Okahata, Yoshio

    IPC分类号： G01N27/00

    CPC分类号： G01N29/036 ,  G01N27/327 ,  G01N2291/0256 ,  Y10T436/255

    摘要： Disclosed are a method of detecting bitter or odor substances, which method comprises adsorbing the bitter or odor substances onto an immobilized bilayer film and directly, quantitatively, separately, and selectively detecting the adsorbed bitter or odor substances, and an apparatus therefor.

    摘要翻译： 本发明公开了检测苦味或臭气物质的方法，该方法包括方法吸附苦味或异味物质走上到固定化双层膜和直接，定量地，单独地和选择性地检测所述吸附苦味或异味物质，并为此设备。

    Process for producing taurine analogues
    3.
    发明公开
    Process for producing taurine analogues 失效
    Verfahren zur Herstellung von Taurin-Analogen

    公开(公告)号：EP0823421A1

    公开(公告)日：1998-02-11

    申请号：EP96401746.1

    申请日：1996-08-07

    申请人： SOGO PHARMACEUTICAL COMPANY LIMITED

    发明人： Ohsumi, Tomoko ,  Tashiro, Tomoyasu ,  Katsumata, Manabu ,  Uchikuga, Saburoh

    IPC分类号： C07C313/02 ,  C07C381/00

    CPC分类号： C07C313/04 ,  C07C313/02

    摘要： The present invention relates to a process for producing amino/guanidinothiosulfonic acid, which comprises treating a styrenedivinylbenzene copolymer sulfonate of amino/guanidinoethyl disulfoxide into contact with an alkali, selectively eluting amino/guanidinosulfinic acid, then reacting this product in a non-aqueous solvent in the presence of a base, and passing the reaction product through a weakly acidic cation exchange resin column; in accordance with the present invention, hypotaurine, thiotaurine and the like having a high purity can industrially be produced.

    摘要翻译： 本发明涉及一种生产氨基/胍基硫代磺酸的方法，其包括将氨基/胍基乙基二亚砜的苯乙烯基二乙烯基苯共聚物磺酸盐与碱接触，选择性地洗脱氨基/胍基亚磺酸，然后使该产物在非水溶剂中反应 碱的存在，并使反应产物通过弱酸性阳离子交换树脂柱; 根据本发明，可以在工业上生产具有高纯度的海牛磺酸，硫代牛磺酸等。

    Method of evaluating the physiological activities and structural characteristics of medicinal substances
    4.
    发明公开
    Method of evaluating the physiological activities and structural characteristics of medicinal substances 失效
    程序的生理活动和药物结构特性的评价。

    公开(公告)号：EP0420683A2

    公开(公告)日：1991-04-03

    申请号：EP90310663.1

    申请日：1990-09-28

    申请人： SOGO PHARMACEUTICAL COMPANY LIMITED

    发明人： Okahata, Yoshio ,  Yomemori, Kazuyuki, c/o Sogo Pharma. Co. Ltd. ,  Fujita, Shinsuke, c/o Sogo Pharma. Co. Ltd.

    IPC分类号： G01N27/00 ,  G01N33/15

    CPC分类号： G01N29/036 ,  G01N33/15 ,  G01N2291/0256

    摘要： A method of evaluating the physioiogical activities and structural characteristics of medicinal substances, which method comprises determining correlations of (A) at least one of kinds of lipid films, physiological activity factors of medicinal substances and structural characteristics of medicinal substances with (B) at least one of amounts of change in frequency, adsorbed amounts or interacted amounts due to adsorption or interaction of the medicinal substances onto the lipid films and lipid film-­water partition coefficients, by use of crystal oscillators cast various lipid films respectively, wherein the lipid film-water partition coefficient is used as a parameter in the structural activity correlation technique for medicinal substances.

    摘要翻译： 评价的physioiogical活动和药用物质，该方法包括（A）确定的采矿相关种脂质膜的，药用物质，并用（B）至少的医药物质结构特征生理活性因子中的至少一个结构特征的方法 在频率变化量中的一个，吸附量或由于吸附或药用物质的相互作用走上脂质膜和脂质 - 电影 - 水分配系数的相互作用量，通过使用分别投各种脂质膜晶体振荡器，worin脂质成膜 水分配系数被用作药用物质的结构活性相关技术的参数。

    Pyrroloquinoline quinones as enzyme inhibitors
    6.
    发明公开
    Pyrroloquinoline quinones as enzyme inhibitors 失效
    吡咯啉喹啉

    公开(公告)号：EP0262345A2

    公开(公告)日：1988-04-06

    申请号：EP87111397.3

    申请日：1987-08-06

    申请人： Sogo Pharmaceutical Company Limited

    发明人： Narutomi, Yuji ,  Katsumata, Manabu ,  Osawa, Yasuko ,  Uchikuga, Saburo

    IPC分类号： A61K31/475

    CPC分类号： A61K31/475

    摘要： The present invention concerns an enzyme inhibitor containing the compound represented by the following formula (I) as an effective ingredient :
    where R represents hydrogen or substituted or not substi­tuted alkyl group, alkenyl group, aryl group or aralkyl group, X represents ORʹ or NRʺR‴, in which Rʹ, Rʺ and R‴ represent respectively hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group.
    The enzyme inhibitor according to the present inven­tion can effectively inhibit aldose reductase, glyoxalase I and reverse transcriptase.

    摘要翻译： 本发明涉及含有下式（I）表示的化合物作为有效成分的酶抑制剂：其中R表示氢或取代或未取代的烷基，烯基，芳基或芳烷基，X表示OR '或NR''R“'，其中R'，R”和R“”分别代表氢或被取代或未取代的烷基，烯基，芳基或芳烷基。 根据本发明的酶抑制剂可以有效抑制醛糖还原酶，乙二醛酶I和逆转录酶。

    Process for producing taurine analogues, such as thiotaurine
    8.
    发明公开
    Process for producing taurine analogues, such as thiotaurine 失效
    威尔法罕zur Herstellung von Taurin-Analogen，wie thiotaurin

    公开(公告)号：EP0884307A3

    公开(公告)日：1999-12-15

    申请号：EP98202760.9

    申请日：1996-08-07

    申请人： SOGO PHARMACEUTICAL COMPANY LIMITED

    发明人： Ohsumi, Tomoko ,  Tashiro, Tomoyasu ,  Katsumata, Manabu ,  Uchikuga, Saburoh

    IPC分类号： C07C313/02 ,  C07C381/00

    CPC分类号： C07C313/02 ,  C07C381/04

    摘要： The present invention relates to a process for producing amino/guanidinothiosulfonic acid, which comprises treating a styrenedivinylbenzene copolymer sulfonate of amino/guanidinoethyl disulfoxide into contact with an alkali, selectively eluting amino/guanidinosulfinic acid, then reacting this product in a non-aqueous solvent in the presence of a base, and passing the reaction product through a weakly acidic cation exchange resin column; in accordance with the present invention, hypotaurine, thiotaurine and the like having a high purity can industrially be produced.

    摘要翻译： 本发明涉及一种生产氨基/胍基硫代磺酸的方法，其包括将氨基/胍基乙基二亚砜的苯乙烯基二乙烯基苯共聚物磺酸盐与碱接触，选择性地洗脱氨基/胍基亚磺酸，然后使该产物在非水溶剂中反应 碱的存在，并使反应产物通过弱酸性阳离子交换树脂柱; 根据本发明，可以在工业上生产具有高纯度的海牛磺酸，硫代牛磺酸等。