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502 条记录 (耗时 0.037 秒)

    CORNEAL ENDOTHELIAL CELL MARKER
    7.
    发明公开
    CORNEAL ENDOTHELIAL CELL MARKER 审中-公开
    HORNHAUTENDOTHEL-ZELLMARKER

    公开(公告)号：EP3029140A1

    公开(公告)日：2016-06-08

    申请号：EP14831264.8

    申请日：2014-07-28

    申请人： Kyoto Prefectural Public University Corporation ,  The Doshisha ,  Senju Pharmaceutical Co., Ltd.

    发明人： KOIZUMI, Noriko ,  OKUMURA, Naoki ,  HIRANO, Hiroatsu ,  KINOSHITA, Shigeru ,  UENO, Morio

    IPC分类号： C12N15/09 ,  A61K35/12 ,  A61L27/00 ,  A61P27/02 ,  C12N5/071 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/56966 ,  A61K35/30 ,  C12N5/0621 ,  G01N2333/705 ,  G01N2333/70596

    摘要： The purpose of the present invention is to provide a method of purification and preparation of cultured corneal endothelial cells, and in particular, to provide cell surface markers for use in corneal endothelial cells not including transformed cells. Provided are cell markers for distinguishing normal cells and transformed cells, in particular normal and transformed corneal endothelium cells. These cell markers relate to specific cell surface markers, for example, to a normal corneal endothelial surface marker such as CD166, and a transformed cell surface marker such as CD73. By using the transformed cell surface marker such as CD73 to remove transformed cells by sorting, it becomes possible to improve purity of a normal cultured corneal endothelium. By using normal corneal endothelial surface marker such as CD166, or by combined use with the transformed cell surface marker, it becomes possible to provide a means for verifying the purity of a prepared corneal endothelium.

    摘要翻译： 本发明的目的是提供一种纯化和制备角膜内皮细胞的方法，特别是提供用于不包括转化细胞的角膜内皮细胞的细胞表面标志物。 提供用于区分正常细胞和转化细胞，特别是正常和转化的角膜内皮细胞的细胞标志物。 这些细胞标志物涉及特定细胞表面标志物，例如与正常角膜内皮表面标志物如CD166和转化的细胞表面标志物如CD73相关。 通过使用转化的细胞表面标志物如CD73通过分选来除去转化的细胞，可以提高正常培养的角膜内皮的纯度。 通过使用正常的角膜内皮表面标志物如CD166，或通过与转化的细胞表面标记物的组合使用，可以提供一种验证制备的角膜内皮的纯度的方法。

    TWO-LAYER SEPARATION-TYPE EYE DROP CONTAINING SQUALANE
    8.
    发明公开
    TWO-LAYER SEPARATION-TYPE EYE DROP CONTAINING SQUALANE 有权
    ZWEISCHICHTIGE GETRENNTE AUGENTROPFEN MIT SQUALAN

    公开(公告)号：EP2977044A1

    公开(公告)日：2016-01-27

    申请号：EP14767461.8

    申请日：2014-03-18

    申请人： Senju Pharmaceutical Co., Ltd.

    发明人： SAWA, Shirou

    IPC分类号： A61K31/01 ,  A61K9/10 ,  A61K31/728 ,  A61K47/32

    CPC分类号： A61K9/08 ,  A61K9/0048 ,  A61K31/01 ,  A61K31/728 ,  A61K47/26 ,  A61K47/32 ,  A61K2300/00

    摘要： The purpose of the present invention is to provide a technique for formulating a two-layer separation-type ophthalmic solution in which, during storage, an aqueous layer and an oil-containing layer containing squalane are separated from each other, wherein it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and the homogeneous dispersed state is maintained in a stable manner at least until administration. A two-layer separation-type ophthalmic solution containing squalane and water, wherein hyaluronic acid and/or a salt thereof and polyvinyl alcohol are contained in the ophthalmic solution and the polyvinyl alcohol content is set to 0.025 to 0.1 w/v%, whereby it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and to maintain the homogeneous dispersed state in a stable manner at least until administration.

    摘要翻译： 本发明的目的是提供一种配制双层分离型眼用溶液的技术，其中在储存期间，水层和含有角鲨烷的含油层彼此分离，其中可以 在含水层中均匀地分散含水层，同时通过在给药前晃动眼用溶液来抑制发泡，并且均匀分散状态至少保持至给药为止保持均匀分散状态。 包含角鲨烷和水的双层分离型眼用溶液，其中透明质酸和/或其盐和聚乙烯醇包含在眼用溶液中，聚乙烯醇含量设定为0.025至0.1w / v％，由此 可以通过在施用前振动眼用溶液来抑制发泡，同时至少在给药前保持均匀的分散状态，使含油层均匀地分散在水层中。

    DIFLUPREDNATE EMULSION COMPOSITION CONTAINING ZINC
    9.
    发明公开
    DIFLUPREDNATE EMULSION COMPOSITION CONTAINING ZINC 有权
    含锌的二元乳液组合物

    公开(公告)号：EP2956144A1

    公开(公告)日：2015-12-23

    申请号：EP14751940.9

    申请日：2014-02-14

    申请人： Senju Pharmaceutical Co., Ltd.

    发明人： IEMOTO, Suzuka ,  YAMAGUCHI, Masazumi ,  YASUEDA, Shinichi

    IPC分类号： A61K31/573 ,  A61K9/107 ,  A61K33/30 ,  A61P27/14 ,  A61P37/08

    CPC分类号： A61K47/02 ,  A61K9/0048 ,  A61K9/107 ,  A61K31/573 ,  A61K33/30 ,  A61K47/26 ,  A61K47/44 ,  A61K2300/00

    摘要： The present invention relates to an emulsion composition containing difluprednate and zinc. The present invention also relates to a method of stabilizing an emulsion composition containing difluprednate, the method includes preparing an emulsion composition comprising difluprednate and zinc. According to the present invention, a difluprednate-containing emulsion composition having excellent preservative efficacy and excellent stability (photostability and heat stability) can be provided.

    摘要翻译： 本发明涉及含有二氟泼尼酯和锌的乳剂组合物。 本发明还涉及稳定含有二氟泼尼酯的乳液组合物的方法，所述方法包括制备包含二氟泼尼酯和锌的乳液组合物。 根据本发明，可以提供具有优异的防腐效力和优异的稳定性（光稳定性和热稳定性）的含有二氟泼尼酯的乳液组合物。