公开(公告)号：EP3131606B1

公开(公告)日：2021-05-19

申请号：EP15715743.9

申请日：2015-04-14

发明人： FRANSSON, Jonas ,  HIMBERT, Hans ,  REINIUS, Pelle

IPC分类号： A61M5/31 ,  A61M5/315

公开(公告)号：EP3288536A1

公开(公告)日：2018-03-07

申请号：EP16722558.0

申请日：2016-04-27

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： FLORIN-ROBERTSSON, Ebba ,  FRANSSON, Jonas ,  MOORE, Barry D.

IPC分类号： A61K9/00 ,  A61K38/20 ,  A61P27/02

CPC分类号： A61K38/2006 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61P27/02 ,  A61P27/04 ,  A61P27/14 ,  A61K2300/00

摘要： The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.

公开(公告)号：EP2817329A4

公开(公告)日：2015-09-02

申请号：EP13752233

申请日：2013-02-19

申请人： SWEDISH ORPHAN BIOVITRUM AB PUBL

发明人： BERGHARD CHARLOTTA ,  BERGLUND MAGNUS ,  STRÖMBERG PATRIK ,  LINDBORG MALIN ,  GUNNERIUSSON ELIN ,  FELDWISCH JOACHIM

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/16 ,  C07K14/195 ,  C07K14/315

CPC分类号： A61K38/164 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/195 ,  C07K14/315 ,  C07K14/47

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatments.

摘要翻译： 本发明涉及C5结合多肽，其包含C5结合基序BM，该基序由选自i）EX2X3X4A X6X7EID X11LPNL X16X17X18QW X21AFIX23X26LX28D的氨基酸序列组成，以及ii）与SEQ ID NO：1至少86％同一性的氨基酸序列 i）中定义的序列，其中多肽与C5结合。 本发明还涉及用于治疗的C5结合多肽，例如用于治疗C5相关病症，以及治疗方法。

公开(公告)号：EP2760467A1

公开(公告)日：2014-08-06

申请号：EP12835172.3

申请日：2012-09-25

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： EK, Vilhelm

IPC分类号： A61K38/46 ,  A61K9/19 ,  A23C9/152 ,  C12N9/18

CPC分类号： C12N9/96 ,  A23L33/40 ,  A61K9/0095 ,  A61K9/19 ,  A61K38/465 ,  A61K47/183 ,  A61K47/26 ,  C12N9/18 ,  C12N9/20 ,  C12Y301/01001 ,  C12Y301/01013

摘要： The present invention relates to improved formulations of recombinant human bile salt stimulated lipase (rhBSSL), including those suitable for forming a lyophilized formulation of rhBSSL, lyophilized formulations of rhBSSL per-se, unit dose forms of rhBSSL and reconstituted formulations of rhBSSL. The formulations of the present invention comprises rhBSSL, a crystalline bulking agent and an amorphous stabilizer that is a different chemical entity to said crystalline bulking agent. The formulations of the present invention have one or more desired properties, including those that relate to stability, decreased aggregation and/or formation of insoluble aggregates in solution. The lyophilized formulations of the present invention have pharmaceutical utility, particularly for the administration of rhBSSL to human infants.

公开(公告)号：EP2710126A1

公开(公告)日：2014-03-26

申请号：EP12785836.3

申请日：2012-05-15

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： STRÖMQUIST, Thomas ,  WOOD, Susanne

IPC分类号： C12N9/18 ,  B01D15/32 ,  B01D15/36 ,  C07K1/18 ,  C07K1/20

CPC分类号： C12N9/20 ,  B01D15/327 ,  B01D15/363

摘要： The invention relates to a process for recovering and purifying bile salt-stimulated lipase (BSSL) in a solution which contains impurities, said process comprising the steps: (i) applying BSSL to a hydrophobic interaction chromatography (HIC) resin; (ii)removing impurities by washing said HIC resin with a wash composition having a pH in the range from 4 to 5; and (iii) recovering BSSL from said HIC resin.

公开(公告)号：EP3642338B1

公开(公告)日：2022-04-27

申请号：EP18717624.3

申请日：2018-04-16

发明人： NILSSON, Joakim ,  NORDLING, Erik ,  SVENSSON GELIUS, Stefan

IPC分类号： C12N9/20

公开(公告)号：EP3511339A1

公开(公告)日：2019-07-17

申请号：EP18213025.2

申请日：2013-02-19

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： BERGHARD, Charlotta ,  BERGLUND, Magnus ,  STRÖMBERG, Patrik ,  LINDBORG, Malin ,  GUNNERIUSSON, Elin ,  FELDWISCH, Joachim

IPC分类号： C07K14/47 ,  C07K14/315 ,  C07K14/195 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  A61K47/64 ,  A61K47/68

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM , which motif consists of an amino acid sequence selected from
i) EX 2 X 3 X 4 A X 6 X 7 EID X 11 LPNL X 16 X 17 X 18 QW X 21 AFIX 25 X 26 LX 28 D, and
ii) an amino acid sequence which has at least 86 % identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatments.

公开(公告)号：EP2211948B1

公开(公告)日：2018-12-12

申请号：EP08852233.9

申请日：2008-11-21

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： FRANSSON, Jonas ,  HJERTMAN, Birger

IPC分类号： A61M5/28 ,  A61M5/19 ,  A61M5/315

CPC分类号： A61M5/284 ,  A61M5/31501 ,  A61M5/31596 ,  A61M2005/1787 ,  A61M2005/3132

摘要： A device for the serial ejection of at least two fluid components comprises a spacer (19) providing at least two states, i) a first state allowing a front piston (7) to be displaced forwards by action on a rear piston (17) while a fluid volume is retained in a rear chamber (5) and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.

公开(公告)号：EP3355912A1

公开(公告)日：2018-08-08

申请号：EP16778742.3

申请日：2016-09-30

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： NORDLING, Erik ,  STRÖMBERG, Patrik ,  SVENSSON GELIUS, Stefan

IPC分类号： A61K38/46 ,  C12N9/16

CPC分类号： A61K38/46 ,  A61K38/00 ,  A61P3/00 ,  C12N9/16 ,  C12Y301/06013

摘要： Disclosed herein are a modified iduronate 2-sulfatase, a composition comprising a modified iduronate 2-sulfatase, as well as methods for preparing a modified iduronate 2-sulfatase and therapeutic use of such a iduronate 2-sulfatase. In particular, the present disclosure relates to a modified iduronate 2-sulfatase sulfatase comprising substantially no epitopes for glycan recognition receptors, wherein said iduronate 2-sulfatase has a catalytic activity of at least 50% of that of unmodified iduronate 2-sulfatase in vitro.

公开(公告)号：EP3038633A1

公开(公告)日：2016-07-06

申请号：EP14765883.5

申请日：2014-08-28

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： NILSSON, Joakim ,  NORDLING, Erik ,  STRÖMBERG, Patrik

IPC分类号： A61K38/00 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/315

摘要： The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence [BM]-[L2]-QSX42X43LLX46EAKKLX52X53X54Q wherein [BM] is a C5 bindingmotif; [L2] is an interconnecting loop; X42 is selected from A and S; X43 is selected from N and E; X46 is selected from A, S and C; X52 is selected from E, N and S; X53 is selected from D, E and S, provided that X53 is not D when X52 is N; and X54 is selected from A and S.

摘要翻译： 本发明涉及能够结合人补体成分5（C5）的多肽，所述多肽包含氨基酸序列[BM] - [L2] -QSX42X43LLX46EAKKLX52X53X54Q，其中[BM]为C5结合基团; [L2]是互连环路; X42选自A和S; X43选自N和E; X46选自A，S和C; X52选自E，N和S; X53选自D，E和S，条件是当X52为N时，X53不为D; X54选自A和S.