公开(公告)号：EP3203904A4

公开(公告)日：2018-05-09

申请号：EP15849401

申请日：2015-10-05

申请人： UNIV PRINCETON

发明人： BUSCHMAN TIM

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61N1/36

CPC分类号： A61N1/36103 ,  A61B5/04001 ,  A61B5/4064 ,  A61B5/4094 ,  A61B5/7264 ,  A61B5/7267 ,  A61N1/36082 ,  A61N1/36139

摘要： An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation pattern for conveying the cognitive variable. The processing unit employs an adaptive algorithm to assemble the stimulation pattern by combination of subset stimulation patterns, the combination of subset stimulation patterns learned by the adaptive algorithm through error analysis.

公开(公告)号：EP3174976A4

公开(公告)日：2018-01-17

申请号：EP15827324

申请日：2015-08-03

申请人： GPB SCIENTIFIC LLC ,  UNIV PRINCETON ,  UNIV MARYLAND

发明人： GRISHAM MICHAEL ,  CIVIN CURT I ,  STURM JAMES C ,  AUSTIN ROBERT H ,  D'SILVA JOSEPH ,  CHEN YU

IPC分类号： C12N9/00 ,  G01N30/00 ,  G01N30/50

CPC分类号： C12N9/00 ,  G01N27/447 ,  G01N30/60

摘要： Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

公开(公告)号：EP2993980A4

公开(公告)日：2017-04-19

申请号：EP14794747

申请日：2014-05-09

申请人： MEMORIAL SLOAN KETTERING CANCER CENTER ,  UNIV PRINCETON

发明人： RABINOWITZ JOSHUA ,  KAMPHORST JURRE ,  CROSS JUSTIN ,  THOMPSON CRAIG

IPC分类号： A01N1/02

CPC分类号： A61K31/20 ,  A23L33/10 ,  A23L33/115 ,  A23L33/12 ,  A23L33/17 ,  A23V2002/00 ,  A61K31/202 ,  A61K36/889 ,  A61K45/06 ,  G01N33/5748 ,  G01N2500/10 ,  G01N2800/52 ,  A61K2300/00 ,  A23V2200/308 ,  A23V2250/18 ,  A23V2250/186

摘要： Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.

摘要翻译： 提供了治疗Ras相关癌症的方法和组合物，其涉及靶向脂质清除。 还提供了用于鉴定和/或表征更多或更少反应性癌症的方法和组合物。

公开(公告)号：EP2859139A4

公开(公告)日：2016-05-18

申请号：EP13800410

申请日：2013-06-06

申请人： UNIV PRINCETON

发明人： MUIR TOM W ,  NGUYEN UYEN T T ,  MUELLER MANUEL M

IPC分类号： C12P19/34 ,  C40B40/02 ,  C40B50/06

CPC分类号： C12Q1/6876 ,  C12N15/1065

摘要： Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.

摘要翻译： 提供了组合物和方法，用于设计师mononucleosome和polynucleosome（染色质阵列）库的DNA条形码以供使用，例如，用于染色质读者，作者，橡皮，和调制器组成的分析。

公开(公告)号：EP2826070A4

公开(公告)日：2015-11-04

申请号：EP13761284

申请日：2013-03-14

申请人： UNIV PRINCETON

发明人： AVASTHI SUSHOBHAN ,  STURM JAMES C ,  MCCLAIN WILLIAM E ,  SCHWARTZ JEFFEREY

IPC分类号： H01L31/074 ,  H01L31/18

CPC分类号： H01L31/074 ,  H01L31/02167 ,  H01L31/022475 ,  H01L31/022491 ,  H01L31/068 ,  H01L31/18 ,  Y02E10/547

公开(公告)号：EP2040843A4

公开(公告)日：2014-04-02

申请号：EP07835785

申请日：2007-05-31

申请人： UNIV PRINCETON

发明人： INGLIS DAVID ,  DAVIS JOHN ,  AUSTIN ROBERT ,  STURM JAMES

IPC分类号： B01L3/00 ,  G01N33/00

CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0472 ,  B01L2400/086 ,  G01N35/025 ,  G01N2001/4072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/149 ,  G01N2035/00465

摘要： The invention is directed to an apparatus and a method of separating particles, such as cells, from a heterogeneous fluid, such as blood, where the particles have a large range of sizes.

公开(公告)号：EP2200645A4

公开(公告)日：2012-07-11

申请号：EP08836810

申请日：2008-10-10

申请人： UNIV PRINCETON

发明人： SHENK THOMAS ,  WANG DAI

IPC分类号： A61K39/245 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16151 ,  C12N2710/16164

公开(公告)号：EP1991662A4

公开(公告)日：2012-03-21

申请号：EP07757293

申请日：2007-02-21

申请人： UNIV PRINCETON

发明人： SCHWARTZ JEFFREY ,  DENNES T JOSEPH

IPC分类号： C12N5/00 ,  A61L27/00 ,  A61L27/30 ,  A61L27/38 ,  A61L31/00 ,  A61L31/08 ,  C08J7/04

CPC分类号： A61L31/082 ,  A61L27/14 ,  A61L27/28 ,  A61L27/30 ,  A61L27/38 ,  A61L27/50 ,  A61L31/005 ,  C08H1/06 ,  C08J7/04 ,  C08J7/045 ,  C08J2379/02 ,  C09J189/04 ,  Y10T428/31504 ,  Y10T428/31536

摘要： Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface with organometallic functional groups remaining unreacted for the subsequent covalent attachment of organic overlayers. Coating methods and coated articles are also disclosed.

摘要翻译： 涂覆有有机金属层的聚合物表面，其中有机金属层和聚合物表面具有使有机金属层与聚合物表面结合的官能团，有机金属官能团保留未反应用于随后共价连接有机覆盖层。 还公开了涂覆方法和涂覆制品。

公开(公告)号：EP1234338A4

公开(公告)日：2009-01-21

申请号：EP00978656

申请日：2000-11-15

申请人： UNIV PRINCETON

发明人： FORREST STEPHEN R ,  BULOVIC VLADIMIR ,  PEUMANS PETER

IPC分类号： H01L51/42 ,  B32B9/04 ,  H01L31/06 ,  H01L51/00 ,  H01L51/30 ,  H01L31/00

CPC分类号： H01L51/4246 ,  B82Y10/00 ,  H01L27/305 ,  H01L27/307 ,  H01L51/0037 ,  H01L51/005 ,  H01L51/0053 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0078 ,  H01L51/4273 ,  H01L2251/308 ,  Y02E10/549 ,  Y10S428/913 ,  Y10T428/24942

摘要： The invention relates to an organic photosensitive optoelectronic device comprising: two electrodes in superposed relation; a hole transport layer (2A02,2B03,2C03) between the two electrodes, the hole transport layer formed of a first photoconductive organic semiconductor material; an electron transport layer (2A03,2B04,2C04) between the two electrodes and adjacent to the hole transport layer, the electron transport layer formed of a second photoconductive organic semiconductor material; and at least one exciton blocking layer (2A04,2B02,2C02,2C05) between the two electrodes and adjacent to at least one of the electrodes.

公开(公告)号：EP1697968A4

公开(公告)日：2008-12-03

申请号：EP04812301

申请日：2004-11-26

申请人： UNIV PRINCETON

发明人： SMITH SHAWN ,  FORREST STEPHEN R

IPC分类号： H01L35/24 ,  G11C13/00 ,  G11C13/02 ,  G11C17/16 ,  H01L20060101 ,  H01L27/28 ,  H01L51/00 ,  H01L51/05 ,  H01L51/30

CPC分类号： H01L51/0587 ,  B82Y10/00 ,  G11C13/0009 ,  G11C13/0014 ,  G11C13/0016 ,  G11C17/16 ,  G11C2213/72 ,  G11C2216/26 ,  H01L27/285 ,  H01L51/0037

摘要： Embodiments of the present invention are directed to low complexity, efficient, two-component memory elements for use in low-cost, robust, and reliable WORM memories. The memory element of one embodiment is an organic-on-inorganic heterojunction diode comprising an organic-polymer layer joined to a doped, inorganic semiconductor layer. The organic polymer layer serves both as one later of a two-later, semiconductor-based diode, as well as a fuse. Application of a voltage greater than a threshold WRITE voltage for a period of time greater than a threshold time interval for a WRITE-voltage pulse irreversibly and dramatically increases the resistivity of the organic polymer layer. The memory element that represents one embodiment of the present invention is more easily manufactured than previously described, separate-fuse-and-diode memory elements, and has the desirable characteristics of being switchable at lower voltages and with significantly shorter-duration WRITE-voltage pulses than the previously described memory elements.