-
公开(公告)号：EP3344278A2
公开(公告)日：2018-07-11
申请号：EP16843113.8
申请日：2016-09-02
发明人： WANG, Feng , TREMBLAY, Matthew S. , YOUNG, Travis , ALVAREZ, Nicole , LIU, Yan , DU, Juanjuan , SCHULTZ, Peter G.
CPC分类号： C07K14/62 , A61P3/10 , C07K16/2854 , C07K2317/24 , C07K2319/00
摘要： Disclosed herein are immunoglobulin fusion proteins comprising an insulin therapeutic peptide and an immunoglobulin region that targets the insulin therapeutic peptide to the liver of an individual in need thereof. Further disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject, for example, diabetes and diabetes related conditions.
-
公开(公告)号：EP3387019A2
公开(公告)日：2018-10-17
申请号：EP16873899.5
申请日：2016-12-09
发明人： WANG, Feng , LIU, Yan , WANG, Ying , FU, Guangsen , SCHULTZ, Peter G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N15/09
CPC分类号： C07K14/64 , C07K2319/00
摘要： Disclosed herein are relaxin immunoglobulin fusion proteins useful for the treatment or prevention of a disease or condition in a subject.
-
公开(公告)号：EP3310376A1
公开(公告)日：2018-04-25
申请号：EP16812418.8
申请日：2016-06-16
发明人： SHEN, Weijun , YANG, Pengyu , SCHULTZ, Peter G.
CPC分类号： A61K31/20 , A61K9/0021 , A61K31/23 , A61K38/13 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K47/542 , A61K47/554 , C07K14/575 , C07K14/57563 , C07K14/605 , A61K2300/00
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
-
公开(公告)号：EP3411069A2
公开(公告)日：2018-12-12
申请号：EP17748229.6
申请日：2017-02-03
发明人： KIM, Chanhyuk , YOUNG, Travis , KIM, Minsoo , MA, Jennifer , PRESTA, Leonard , SCHULTZ, Peter G.
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C07K19/00 , C12N15/13
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6849 , A61K47/6869 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The present invention provides for humanized anti-CD3 antibodies and conjugates thereof. These conjugates may be useful in the treatment of conditions such as prostate cancer.
-
公开(公告)号：EP3270946A2
公开(公告)日：2018-01-24
申请号：EP16765746.9
申请日：2016-03-17
CPC分类号： A61K47/12 , A61K38/2221 , A61K47/14 , A61P29/00
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. One half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents comprising a half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.
-
6.发明公开
公开(公告)号：EP3082797A1
公开(公告)日：2016-10-26
申请号：EP14872951.0
申请日：2014-12-17
发明人： SHEN, Weijun , YANG, Pengyu , ZOU, Huafei , SCHULTZ, Peter G.
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0021 , A61K9/703 , A61K38/2278 , A61K38/26 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K47/60
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
摘要翻译： 提供了用于延长治疗剂的半衰期的方法和组合物。 改性治疗剂（mTA）包含治疗剂，短纤维和半衰期延长分子。 本文公开的mTA可用于治疗有需要的受试者的疾病或病症。
-
公开(公告)号：EP3043824A1
公开(公告)日：2016-07-20
申请号：EP14843357.6
申请日：2014-09-12
发明人： SHEN, Weijun , SCHULTZ, Peter G. , MUPPIDI, Avinash , CRAMERI, Andreas , AHMAD, Insha , YANG, Pengyu
CPC分类号： A61K47/48046 , A61K38/1709 , A61K38/1825 , A61K38/1875 , A61K38/22 , A61K38/2221 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/54 , A61K47/543 , A61K47/554
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.
摘要翻译： 提供了用于延长治疗剂的半衰期的方法和组合物。 一个或多个半衰期延长部分可以连接到治疗剂，从而延长治疗剂的半衰期。 包含与治疗剂连接的一个或多个半衰期延长部分的修饰治疗剂（mTA）可用于治疗有需要的受试者的疾病或病症。
-
公开(公告)号：EP3016944A1
公开(公告)日：2016-05-11
申请号：EP14819564.7
申请日：2014-07-02
IPC分类号： C07D403/12 , C07D403/10 , A61K31/497 , A61P1/18 , A61P11/00
CPC分类号： C07D241/32 , C07C279/18 , C07D241/28 , C07D241/34 , C07D403/12
摘要： Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.
摘要翻译： 本文描述了用于治疗囊性纤维化的化合物，组合物和方法。
-
9.发明公开OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF 审中-公开优化的基于PNE的嵌套式接受器T细胞开关及其应用
公开(公告)号：EP3283113A2
公开(公告)日：2018-02-21
申请号：EP16780958.1
申请日：2016-04-15
发明人： YOUNG, Travis , RODGERS, David T. , HARDY, Ian , KIM, Chanhyuk , SCHULTZ, Peter G. , HAMPTON, Eric , LABORDA, Eduardo , PRESTA, Leonard
IPC分类号： A61K39/395 , C07K14/395 , C07K16/28 , C07K16/32 , C07K16/40 , C07K16/46
CPC分类号： C07K16/32 , A61K35/17 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/585 , C07K16/18 , C07K16/2803 , C07K16/2851 , C07K16/2866 , C07K16/2878 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/03 , C07K2319/33
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.027 秒)
