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1.发明公开
公开(公告)号：EP4327838A3
公开(公告)日：2024-04-24
申请号：EP23220770.4
申请日：2021-10-21
申请人： Axogen Corporation
发明人： FALERIS, Jennifer , TAJDARAN, Kasra
CPC分类号： A61L27/3604 , A61L27/3675 , A61L27/3687 , A61L27/3691 , A61L27/44 , A61L27/54 , A61L27/58 , A61L2300/4120130101 , A61L2300/41420130101 , A61L2300/42620130101 , A61L2300/6420130101 , A61L2430/3220130101 , A61L2430/4020130101
摘要： The present disclosure provides fasciculated nerve grafts of customizable lengths and diameters, and methods of preparing the same. The grafts are made by digesting native extracellular matrix (ECM) around the nerve fascicles of a nerve tissue, and the epineurial sheath. One or more of the individual fascicles may then be entubulated in an entubulation material, embedded in or coated with a coating material, or both, to form a fasciculated nerve graft. The fasciculated nerve grafts are customizable and designed to bridge nerve gaps; the modularity of the fasciculated nerve graft allows for restoring continuity to nerve defects of virtually any length and allows for matching the diameter of the patient's recipient nerve.
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公开(公告)号：EP3302353A1
公开(公告)日：2018-04-11
申请号：EP16800479.4
申请日：2016-05-06
CPC分类号： A61L27/3675 , A61K35/12 , A61K35/30 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L2430/32 , A61L2430/40 , C12N5/062 , C12N2501/734
摘要： This document relates to decellularized nerve allografts. For example, decellularized nerve allografts and methods and materials for using decellularized nerve allografts to repair nerve injuries or bridge a severed nerve are provided.
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公开(公告)号：EP3291851A1
公开(公告)日：2018-03-14
申请号：EP16789988.9
申请日：2016-05-04
发明人： LEWIS, Jennifer A. , HOMAN, Kimberly A. , KOLESKY, David B. , TRUBY, Ryan L. , SKYLAR-SCOTT, Mark A.
CPC分类号： A61L27/3804 , A61F2/04 , A61F2240/002 , A61L27/18 , A61L27/3633 , A61L27/3675 , A61L27/3808 , A61L27/3834 , A61L27/3878 , A61L27/3891 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/62 , A61L2300/64 , A61L2400/08 , A61L2430/26 , A61L2430/32 , B29C64/106 , B33Y10/00 , B33Y80/00
摘要： A 3D printed tubular construct, such as a nephron, with or without embedded vasculature as well as methods of printing tubular tissue constructs are described.
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公开(公告)号：EP3253394A1
公开(公告)日：2017-12-13
申请号：EP16746227.4
申请日：2016-01-31
发明人： LEVENBERG, Shulamit , PITARU, Sandu , OFFEN D, Daniel , GANZ, Javier , COHEN-MATSLIAH, Sivan Ida , SHOR, Erez
CPC分类号： A61K35/38 , A61K9/0085 , A61L27/26 , A61L27/3604 , A61L27/3675 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/64 , A61L2430/32 , A61L2430/38 , C12N5/0632 , C12N2533/40 , C12N2533/56
摘要： A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a subject, wherein the scaffold is seeded with oral mucosa stem cells (OMSC) and/or cells that have been ex vivo differentiated from said OMSCs, thereby treating the spinal cord injury.
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公开(公告)号：EP1617854B1
公开(公告)日：2014-08-06
申请号：EP04713755.9
申请日：2004-02-23
发明人： SINGH, Raj , SIEGAL, Gene
CPC分类号： C12N5/0068 , A61K35/30 , A61K38/00 , A61K38/18 , A61K39/385 , A61K2039/6056 , A61L27/3604 , A61L27/3675 , A61L27/3683 , A61L27/383 , A61L27/3878 , A61L27/52 , A61L2430/32 , C07K14/78 , C12N5/0619 , C12N2533/90 , C12N2533/92 , A61K2300/00
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公开(公告)号：EP3407925A1
公开(公告)日：2018-12-05
申请号：EP17744966.7
申请日：2017-01-27
申请人： Tissuetech, Inc.
发明人： TSENG, Scheffer
CPC分类号： A61L27/3683 , A61L27/3604 , A61L27/3645 , A61L27/365 , A61L27/3654 , A61L27/3662 , A61L27/3666 , A61L27/367 , A61L27/3675 , A61L27/60
摘要： Methods of treating a complex wound by administering to a complex wound in the individual a therapeutically effective amount of a fetal support tissue product to treat the complex wound. Methods of treating a complex lower extremity ulcer by administering to a complex lower extremity ulcer in the individual a therapeutically effective amount of a fetal support tissue product to treat the complex lower extremity ulcer. Methods of reducing or preventing scar formation from granulation tissue by administering a fetal support tissue product to granulation tissue. Methods of repairing a spina bifida defect by administering to the defect in the individual a therapeutically effective amount of an umbilical cord product.
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公开(公告)号：EP3370791A1
公开(公告)日：2018-09-12
申请号：EP16805222.3
申请日：2016-11-03
发明人： BARANES, Danny , WEISS, Orly Eva , CHANJI, Eyal , MORAD, Tzachy , HAMMER, Liat , MERFELD, Ido
CPC分类号： A61L27/46 , A61L27/3616 , A61L27/3675 , A61L27/38 , A61L27/446 , A61L27/54 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2430/32
摘要： Methods and compositions for repair and regeneration of neural tissue are provided. Particularly, methods and compositions for promoting neural tissue wound healing and treatment of traumatic brain injury using porous crystalline calcium carbonate particles and a biocompatible polymer, for example compositions comprising porous coral exoskeleton particles in combination with a biocompatible polymer, and optionally comprising neural growth agents and platelets for application to damaged neural tissue for enhancing neural regrowth and recovered functionality, in, for example, but not limited to, traumatic brain injury (TBI).
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公开(公告)号：EP3370624A1
公开(公告)日：2018-09-12
申请号：EP16863151.3
申请日：2016-11-07
申请人： Axogen Corporation
CPC分类号： A61B17/1128 , A61B2017/00902 , A61B2017/1132 , A61B2017/1135 , A61L27/16 , A61L27/18 , A61L27/3604 , A61L27/3675 , A61L27/56 , A61L2430/32 , C08L23/06 , C08L71/02
摘要： The problem of attaching a donor nerve stump to a recipient nerve for an end-to-side coaptation is solved by the use of a tissue connector. The tissue connector can have a body for receiving the donor nerve stump and one or more overflaps for attaching the tissue connector with the donor nerve stump therein to the epineurium on the side of the recipient nerve. Sutures can also be used to secure the tissue connector and nerves in place.
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公开(公告)号：EP3360585A1
公开(公告)日：2018-08-15
申请号：EP17204887.8
申请日：2014-03-14
申请人： Celularity, Inc.
CPC分类号： A61L27/3633 , A61L27/3662 , A61L27/3675 , A61L27/3687 , A61L27/3691 , A61L27/3834 , A61L2300/416 , A61L2430/10 , A61L2430/32 , A61L2430/38 , A61L2430/40
摘要： Provided herein are methods of producing extracellular matrix (ECM) comprising a double-drying method. Provided is also an ECM prepared by said method for use in filling, sealing or treating a void in an individual.
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公开(公告)号：EP3196305A4
公开(公告)日：2018-04-25
申请号：EP15839728
申请日：2015-09-11
发明人： SOWA YOSHIHIRO , KISHIDA TSUNAO , MAZDA OSAM
CPC分类号： A61L27/383 , A61K35/12 , A61K35/30 , A61L27/00 , A61L27/3675 , A61L27/3895 , A61L27/54 , A61L2430/32 , A61P25/00 , C12N5/0622 , C12N5/10 , C12N15/09 , C12N2501/60 , C12N2506/09 , C12N2506/1384 , C12N2506/28
摘要： The present invention addresses the problem of providing a method for obtaining Schwann cells directly (by direct reprogramming) without passing through pluripotent stem cells, such as ES cells or iPS cells. As a means for solving this problem, the present invention provides a method for preparing Schwann cells that includes a step of introducing into somatic cells of a mammal at least one gene selected from the group consisting of SOX10 genes and KROX20 genes, or an expression product thereof.
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