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公开(公告)号：EP3253394A1
公开(公告)日：2017-12-13
申请号：EP16746227.4
申请日：2016-01-31
发明人： LEVENBERG, Shulamit , PITARU, Sandu , OFFEN D, Daniel , GANZ, Javier , COHEN-MATSLIAH, Sivan Ida , SHOR, Erez
CPC分类号： A61K35/38 , A61K9/0085 , A61L27/26 , A61L27/3604 , A61L27/3675 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/64 , A61L2430/32 , A61L2430/38 , C12N5/0632 , C12N2533/40 , C12N2533/56
摘要： A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a subject, wherein the scaffold is seeded with oral mucosa stem cells (OMSC) and/or cells that have been ex vivo differentiated from said OMSCs, thereby treating the spinal cord injury.
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公开(公告)号：EP3773506A1
公开(公告)日：2021-02-17
申请号：EP19775863.4
申请日：2019-03-27
IPC分类号： A61K9/127 , A61K31/7088 , A61K35/28 , C12N15/113
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公开(公告)号：EP2132302A1
公开(公告)日：2009-12-16
申请号：EP08719962.6
申请日：2008-03-12
CPC分类号： C12N5/0677 , A61K35/33 , A61K35/39 , A61K35/44 , A61K35/51 , A61K35/54 , A61K38/00 , A61L27/3804 , A61L27/3886 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/43 , A61L2300/604 , C12N2502/1323 , C12N2502/28 , C12N2533/40 , C12N2533/52 , C12N2533/90
摘要： An isolated composition of matter is provided comprising a heterogeneous population of cells seeded on a surface of a scaffold, wherein the heterogeneous population of cells comprises at least one pancreatic islet, endothelial cells and fibroblast cells. Methods of generating same and uses thereof are also provided.
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公开(公告)号：EP2370115B1
公开(公告)日：2016-08-03
申请号：EP09796100.7
申请日：2009-12-06
发明人： KAULLY, Tamar , LEVENBERG, Shulamit
CPC分类号： A61K9/0007 , A61K47/58 , A61K47/60 , A61L24/0031 , A61L24/0036 , A61L27/52 , A61L27/56
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公开(公告)号：EP2132302B1
公开(公告)日：2016-01-27
申请号：EP08719962.6
申请日：2008-03-12
IPC分类号： C12N5/071 , A61L27/38 , A61L27/54 , A61L27/56 , A61K35/51 , A61K35/54 , A61K35/39 , A61K35/33
CPC分类号： C12N5/0677 , A61K35/33 , A61K35/39 , A61K35/44 , A61K35/51 , A61K35/54 , A61K38/00 , A61L27/3804 , A61L27/3886 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/43 , A61L2300/604 , C12N2502/1323 , C12N2502/28 , C12N2533/40 , C12N2533/52 , C12N2533/90
摘要： An isolated composition of matter is provided comprising a heterogeneous population of cells seeded on a surface of a scaffold, wherein the heterogeneous population of cells comprises at least one pancreatic islet, endothelial cells and fibroblast cells. Methods of generating same and uses thereof are also provided.
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公开(公告)号：EP2291556A2
公开(公告)日：2011-03-09
申请号：EP09762169.2
申请日：2009-06-08
CPC分类号： D01D5/0046 , A61L27/14 , A61L27/38 , D04H1/728 , Y10T156/10
摘要： A method for fabricating a nonwoven structure is disclosed. The method comprises: forming a nonwoven layer of polymer fibers on a collector liquid surface, transferring the layer to a solid surface, and repeating the formation and transfer in a layerwise manner. The method is generally effected by spinning liquefied polymer, in particular by employing electrostatic or hydrostatic forces. The nonwoven structure formed comprises a plurality of nonwoven layers: the average thickness of the nonwoven structure is at least 0.5 mm and the structure has an overall porosity of at least 90%. The nonwoven structure can be used in forming a scaffold for tissue engineering, in particular a cell-scaffold composition, suitable for implanting in a patient, wherein at least one cell population is seeded on at least one of the plurality of layers.
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公开(公告)号：EP3253311A1
公开(公告)日：2017-12-13
申请号：EP16746230.8
申请日：2016-02-02
CPC分类号： A61K35/30 , A61L27/18 , A61L27/3834 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2430/38 , C08L67/04
摘要： Methods of treating spinal cord injuries are disclosed. The method comprises implanting scaffolds comprising a protruding scaffold and a supporting scaffold, wherein at least a portion of the protruding scaffold is inserted into a lesioned area of the spinal cord so as to contact the injury or diseased site, wherein the supporting scaffold does not protrude into the injury or diseased site and is in contact with the rostral and/or caudal dura of the spinal cord.
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公开(公告)号：EP3775155A1
公开(公告)日：2021-02-17
申请号：EP19786042.2
申请日：2019-04-10
发明人： LEVENBERG, Shulamit , ZOHAR, Barak
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公开(公告)号：EP3041522A1
公开(公告)日：2016-07-13
申请号：EP14789896.9
申请日：2014-09-02
CPC分类号： A61L27/18 , A61L27/3625 , A61L27/3695 , A61L27/3808 , A61L27/3886 , A61L27/3895 , A61L27/56 , A61L2300/64 , A61L2430/34 , C12N5/0658 , C12N5/069 , C12N2502/13 , C12N2502/1335 , C12N2533/40 , C08L67/04
摘要： The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention.
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公开(公告)号：EP2945741A1
公开(公告)日：2015-11-25
申请号：EP14740619.3
申请日：2014-01-15
CPC分类号： B01L3/502723 , B01L3/5027 , B01L2200/0605 , B01L2200/0673 , B01L2200/0694 , B01L2200/16 , B01L2300/048 , B01L2300/0816 , B01L2300/0864 , B01L2300/0896 , B01L2300/12 , B01L2400/0406 , G01N1/18 , G01N1/30 , Y10T436/2575
摘要： A microfluidic device includes a platform with a microstructure. The microstructure include a primary channel and a plurality of chambers that open to the primary channel to enable a sample fluid that is loaded into the device via the primary channel to flow into the chambers. Each chamber has a volume that is less than tens of nanoliters and is connected by a vent to a secondary channel of the microstructure. A width of the vent is configured to enable a gas to escape from the chamber to the secondary channel while inhibiting flow of the sample fluid from the chamber into the secondary channel.
摘要翻译： 微流体装置包括具有微结构的平台。 微结构包括主通道和多个通向主通道的腔室，以使得通过主通道加载到装置中的样本流体能够流入腔室。 每个腔室具有小于数十纳升的体积并且通过通风口连接到微结构的次级通道。 排气口的宽度构造成使气体能够从腔室逸出到次通道，同时抑制样品流体从腔室流入次通道。
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