METHOD FOR PRODUCING GRANULES
    5.
    发明公开
    METHOD FOR PRODUCING GRANULES 有权
    VERFAHREN ZUR GRANULATHERSTELLUNG

    公开(公告)号:EP1852100A1

    公开(公告)日:2007-11-07

    申请号:EP06714594.6

    申请日:2006-02-24

    Abstract: In a production process of granules containing a biologically active substance, variation in the elution profile of the biologically active substance is reduced by heating the temperature of granules to about 50°C or higher and maintaining the temperature for about 1 minute or longer. By setting the spray speed to about 90 mg/min or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1.5 g/cm 2 or more, the variation in the elution profile of the biologically active substance from the granules is reduced.

    Abstract translation: 在含有生物活性物质的颗粒的生产方法中,通过将颗粒的温度加热至约50℃或更高并保持约1分钟或更长时间来降低生物活性物质的洗脱曲线的变化。 当喷雾含有生物活性物质的初级试剂的喷雾剂,同时向核心喷洒粘合液体并设定每单位面积的总进料量时,通过将喷雾速度设定为每1g核心约90mg / min以上 对于离心流化床包衣造粒机至约1.5g / cm 2或更高,来自颗粒的生物活性物质的洗脱曲线的变化减小。

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