SYSTEM FOR SOLID PHASE REACTIONS
    2.
    发明公开
    SYSTEM FOR SOLID PHASE REACTIONS 失效
    用于固相反应的系统

    公开(公告)号:EP0644792A1

    公开(公告)日:1995-03-29

    申请号:EP92919521.0

    申请日:1992-09-03

    摘要: A rotating processor (10) is disclosed. The apparatus (10) includes a hollow enclosed rotor (12), a rotor drive (104), internal space (24) to hold particulate porous reaction or separations media which may be porous, lines (40) connecting the center and periphera of the internal space with the exterior the through fluid line seals, valuing to control fluid flow, gradient makers, and a microprocessor to control and monitor the entire system. Optionally the rotor (12) may be spun with the axis vertical or horizontal, and may be used as a conventional column at rest. The rotating processor (10) permits any synthetic or separative process utilizing particulate or solid phase supports, or separations involving phases of different density to be accomplished under conditions which facilitate precise control of fluid flow and minimization of both micro- and macro-anomalous flow. A computer-controlled flat multiport valve system is also described to facilitate programmed scheduling of reagents through the rotor (12). Also disclosed are a process of synthesizing a polymer using the rotor (12) and a process of separating molecules using the processor (10).

    摘要翻译: 公开了一种旋转处理器(10)。 装置(10)包括中空封闭转子(12),转子驱动装置(104),用于保持微粒多孔反应的内部空间(24)或可以是多孔的分离介质,连接中心和外围的管线(40) 内部空间与外部流体管线密封,控制流体流动的重要性,梯度制造商以及微处理器来控制和监控整个系统。 可选地,转子(12)可以轴线垂直或水平地旋转,并且可以在休息时用作常规柱。 旋转处理器(10)允许在促进流体流动的精确控制和微观和宏观反常流动的最小化的条件下完成利用颗粒或固相支撑物的任何合成或分离过程或涉及不同密度相的分离。 还描述了计算机控制的扁平多端口阀门系统以促进试剂通过转子(12)的程序化调度。 还公开了使用转子(12)合成聚合物的过程和使用处理器(10)分离分子的过程。