公开(公告)号：EP1065001A4

公开(公告)日：2004-04-14

申请号：EP99909237

申请日：1999-03-18

申请人： PREC SYSTEM SCIENCE CO LTD

发明人： TAJIMA H

IPC分类号： B01J19/00 ,  B01L3/00 ,  B03C1/025 ,  B03C1/035 ,  C40B40/06 ,  C40B60/14 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  B03C1/00 ,  C12M1/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00292 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01L3/0231 ,  B01L3/5025 ,  B01L2300/0829 ,  B03C1/025 ,  B03C1/033 ,  B03C1/035 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/1074 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A method for making any combined substances in carriers by arbitrarily combining with plural elements of substances, comprising the steps of: dispensing each liquid incorporating each element of substances into one or more groups of containing parts arranged by plural containing parts in a matrix in which the containing parts accommodating said carriers are arranged in rows or columns having a predetermined number width in a way so as to be included in said matrix, according to the structure of the specified combined substances or the utilized kinds of containing parts, and mixing the dispensed elements of substances into the group of the containing parts accommodating the carriers, with the elements of substances arranged in rows or columns having a predetermined number width, in such a manner that row-like or column-like arrangements of the dispensed elements of substances are positioned against row-like or column-like arrangements of the elements of substances in a state of transposition or non-transposition.

公开(公告)号：EP0804281B1

公开(公告)日：2002-06-05

申请号：EP96906212.4

申请日：1996-01-19

申请人： SELECTIDE CORPORATION

发明人： KRCHNAK, Viktor ,  LEBL, Michal ,  SELIGMANN, Bruce

IPC分类号： C07K1/04 ,  G05B13/00 ,  B01J19/00 ,  B25J9/16

CPC分类号： B25J9/1679 ,  B01J19/0046 ,  B01J2219/00288 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00725 ,  C07K1/045 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14 ,  G05B2219/40101 ,  G05B2219/45092 ,  Y10S706/906

摘要： A solid phase synthesis system is provided by employing a fully automated robot (20) that operates with a novel timing protocol executed by a computer (25) for handling multiple synthetic tasks efficiently. The fully automated robot (20) moves along a track (35) and is equipped with a gripper arm (30) which can pick up, position, and operate syringes (40, 60) which can contain solid supports and amino acid reactants. The novel timing protocol is realized by performing steps in the synthesis cycles for different compounds, such as peptides, concurrently rather than on a sequential basis.

公开(公告)号：EP1671703A3

公开(公告)日：2006-07-05

申请号：EP06004271.0

申请日：1999-03-18

申请人： PRECISION SYSTEM SCIENCE CO., LTD.

发明人： Tajima, Hideji

IPC分类号： B03C1/00 ,  C12M1/00 ,  B01J19/00 ,  G01N35/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00292 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01L3/0231 ,  B01L3/5025 ,  B01L2300/0829 ,  B03C1/025 ,  B03C1/033 ,  B03C1/035 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/1074 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A method for making any combined substances in carriers by arbitrarily combining with plural elements of substances, comprising the steps of:
dispensing each liquid incorporating each element of substances into one or more groups of containing parts arranged by plural containing parts in a matrix in which the containing parts accommodating said carriers are arranged in rows or columns having a predetermined number width in a way so as to be included in said matrix, according to the structure of the specified combined substances or the utilized kinds of containing parts, and
mixing the dispensed elements of substances into the group of the containing parts accommodating the carriers, with the elements of substances arranged in rows or columns having a predetermined number width, in such a manner that row-like or column-like arrangements of the dispensed elements of substances are positioned against row-like or column-like arrangements of the elements of substances in a state of transposition or non-transposition.

公开(公告)号：EP0355266B1

公开(公告)日：1993-06-09

申请号：EP89107707.5

申请日：1989-04-27

申请人： MILLIPORE CORPORATION

发明人： Hudson, Derek ,  Honig, Jordan ,  Cook, Ronald M. ,  Ng, Douglas J.

IPC分类号： B01J19/00 ,  C07K1/04

CPC分类号： C07K1/045 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/005 ,  B01J2219/00549 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00725 ,  B01J2219/00731 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  Y10T436/11

公开(公告)号：EP0798307B1

公开(公告)日：2003-03-19

申请号：EP97105302.0

申请日：1997-03-27

申请人： NKK Plant Engineering Corporation

发明人： YAMAZAKI, Shigeki, c/o NKK PLANT ENGINEERING CORP. ,  OHSAKI, Katsuhiko

IPC分类号： C07H5/02 ,  B01J19/00 ,  B01J31/08

CPC分类号： B01J31/0239 ,  B01J19/0046 ,  B01J31/0268 ,  B01J31/08 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/0072 ,  B01J2531/98 ,  C07H5/02 ,  C40B60/14

公开(公告)号：EP1065001A1

公开(公告)日：2001-01-03

申请号：EP99909237.2

申请日：1999-03-18

申请人： Precision System Science Co., Ltd.

发明人： TAJIMA, H., Precision System Science Co., Ltd.

IPC分类号： B03C1/00 ,  C12M1/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00292 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01L3/0231 ,  B01L3/5025 ,  B01L2300/0829 ,  B03C1/025 ,  B03C1/033 ,  B03C1/035 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/1074 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

摘要： The present invention relates to an apparatus for an integrated process of magnetic particles and a method of controlling the same, for executing a process for magnetic particles incorporated in a fluid in an integrated state. The present invention aims to provide an apparatus for an integrated process of magnetic particles and a method of controlling the same, that can promptly and efficiently process all together in high precision, with the process of magnetic particles integrated.
The apparatus for an integrated process of magnetic particles comprises a reservoir body provided with plural pit-like reservoirs for storing a drawn liquid arranged in a matrix, a sliding body with jutting plural sliding projections sliding through the reservoirs and capable of moving vertically to and from the reservoir body, plural nozzles attached to the lower parts of the reservoirs and capable of passing the liquid therethrough, a magnetic force device capable of magnetization and demagnetization having plural through sections in which is inserted each nozzle and having a wall part in contact with or near the outer side surface of the nozzle, with the nozzles inserted thereinto, wherein each wall part has two divided wall parts being apart from one another in such a manner that the divided wall parts have opposite polarities by magnetization, respectively.

摘要翻译： 本发明涉及一种用于磁性颗粒的集成过程的装置及其控制方法，用于执行一体化状态下结合在流体中的磁性颗粒的过程。 本发明的目的在于提供一种磁性粒子的集成方法的装置及其控制方法，其可以将磁性粒子整合的过程以高精度快速高效地一起处理。 用于磁性颗粒的集成过程的装置包括储存器主体，其设置有多个凹坑状储存器，用于储存以矩阵形式布置的拉伸液体，滑动体具有突出的多个滑动突起，其滑动通过储存器并且能够垂直移动和移出 储存器本体，附接到储存器的下部并且能够使液体通过的多个喷嘴，能够进行磁化和退磁的磁力装置，其具有插入每个喷嘴的多个贯穿部分，并且具有壁部分接触或 在喷嘴的外侧表面附近，喷嘴插入其中，其中每个壁部分分别具有两个分开的壁部分，以使分隔的壁部分分别具有相对的磁化极性。

公开(公告)号：EP0804281A1

公开(公告)日：1997-11-05

申请号：EP96906212.0

申请日：1996-01-19

申请人： SELECTIDE CORPORATION

发明人： KRCHNAK, Viktor ,  LEBL, Michal ,  SELIGMANN, Bruce

IPC分类号： B01J19 ,  B25J9 ,  C07K1 ,  C40B40 ,  C40B60

CPC分类号： B25J9/1679 ,  B01J19/0046 ,  B01J2219/00288 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00353 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00725 ,  C07K1/045 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14 ,  G05B2219/40101 ,  G05B2219/45092 ,  Y10S706/906

摘要： A solid phase synthesis system is provided by employing a fully automated robot (20) that operates with a novel timing protocol executed by a computer (25) for handling multiple synthetic tasks efficiently. The fully automated robot (20) moves along a track (35) and is equipped with a gripper arm (30) which can pick up, position, and operate syringes (40, 60) which can contain solid supports and amino acid reactants. The novel timing protocol is realized by performing steps in the synthesis cycles for different compounds, such as peptides, concurrently rather than on a sequential basis.

公开(公告)号：EP3267962A1

公开(公告)日：2018-01-17

申请号：EP16762580.5

申请日：2016-03-11

申请人： The Trustees of The University of Pennsylvania ,  Hogan, Michael

发明人： HOGAN, Michael ,  TELHAN, Orkan M. ,  HOGAN, Karen

IPC分类号： A61J1/00 ,  B01J19/00 ,  B01J19/26 ,  C12M1/34

CPC分类号： C12M33/04 ,  B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00326 ,  B01J2219/00353 ,  B01J2219/00376 ,  B01J2219/0054 ,  B01J2219/00547 ,  B01J2219/00576 ,  B01J2219/00691 ,  B01J2219/00702 ,  B01J2219/0074 ,  C12M23/44 ,  C12M23/50 ,  C12M31/04 ,  C12M35/02 ,  C12M41/34 ,  C12M41/46 ,  C12M41/48 ,  C12M47/06 ,  C12M47/12

摘要： A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. Methods for transferring a fluid are also disclosed.

公开(公告)号：EP1065001B1

公开(公告)日：2008-09-24

申请号：EP99909237.2

申请日：1999-03-18

申请人： PRECISION SYSTEM SCIENCE CO., LTD.

发明人： TAJIMA, H., Precision System Science Co., Ltd.

IPC分类号： B03C1/00 ,  C12M1/00 ,  B01J19/00 ,  G01N35/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00292 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00369 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01L3/0231 ,  B01L3/5025 ,  B01L2300/0829 ,  B03C1/025 ,  B03C1/033 ,  B03C1/035 ,  B03C1/284 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/1074 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

公开(公告)号：EP1134228B1

公开(公告)日：2003-03-05

申请号：EP01115180.0

申请日：1997-03-27

申请人： NKK Plant Engineering Corporation

发明人： Yamazaki, Shigeki, c/o NKK Plant Engineering ,  Ohsaki, Katsuhiko, c/o NKK Corp.

IPC分类号： C07H5/02 ,  B01J19/00 ,  B01J31/08

CPC分类号： B01J31/0239 ,  B01J19/0046 ,  B01J31/0268 ,  B01J31/08 ,  B01J2219/00286 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/0072 ,  B01J2531/98 ,  C07H5/02 ,  C40B60/14