公开(公告)号：EP1789185B1

公开(公告)日：2015-03-04

申请号：EP05808509.3

申请日：2005-09-15

申请人： LG Chem, Ltd.

发明人： JEON, You-Moon ,  KO, Donghyun ,  EOM, Sungshik ,  KWON, O-Hak ,  CHOI, Jaehui

IPC分类号： B01J31/18 ,  B01J31/22 ,  B01J31/20 ,  B01J31/24 ,  C07F9/46 ,  C07F9/572 ,  C07F15/00 ,  C07C45/50

CPC分类号： B01J31/2404 ,  B01J31/1855 ,  B01J31/186 ,  B01J31/188 ,  B01J31/20 ,  B01J31/2234 ,  B01J2231/321 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/845 ,  C07C45/50 ,  C07F9/46 ,  C07F9/5721 ,  C07F15/008 ,  C07C47/02

摘要： Provided are a catalyst composition including a transition metal catalyst and a nitrogen-containing bidentate phosphorus compound and a process for hydroformylation reaction of olefins to prepare aldehydes which includes stirring the catalyst composition, an olefin compound, and a gas mixture of of carbon monoxide and hydrogen, under high temperature and pressure condition. Therefore, very high catalytic activity and high selectivity in normal-aldehyde or iso-aldehyde according to the type of a substiuent are ensured.

公开(公告)号：EP1325013A2

公开(公告)日：2003-07-09

申请号：EP01950115.4

申请日：2001-07-06

申请人： DSM N.V.

发明人： BERG VAN DEN, Michel ,  MINNAARD, Adriaan, Jacobus ,  FERINGA, Ben ,  VRIES DE, Johannes, Gerardus

IPC分类号： C07F15/00 ,  C07F9/6571 ,  B01J31/18 ,  C07B53/00 ,  C07H9/02

CPC分类号： C07F15/0073 ,  B01J31/1855 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/303 ,  C07F9/657154 ,  C07F15/0046 ,  C07C69/34

摘要： Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a ligand, a ranges from 0.5 to 3 and b anc c, each independently, range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms, R?1 and R2¿ each independently represent H, an optionally substituted alkyl, aryl, alkaryl or aralkyl group or may form a (heterocyclic) ring together with the N-atom to which they are bound. And a process for the asymmetric (transfer) hydrogenation of an olefinically unsaturated compound, ketone, imine or oxime derivate in the presence of a hydrogen donor and of a catalyst, use being made of a catalyst represented by formula ML¿a?XbSc, where M is a transition metal, to be chosen from rhodium, iridium and ruthenium, X I a counter ion, S is a ligand, a ranges from 0.5 to 3 and b and c range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms; and R?1 and R2¿ are as defined above.

公开(公告)号：EP1789185B2

公开(公告)日：2018-07-25

申请号：EP05808509.3

申请日：2005-09-15

申请人： LG Chem, Ltd.

发明人： JEON, You-Moon ,  KO, Donghyun ,  EOM, Sungshik ,  KWON, O-Hak ,  CHOI, Jaehui

IPC分类号： B01J31/18 ,  B01J31/22 ,  B01J31/20 ,  B01J31/24 ,  C07F9/46 ,  C07F9/572 ,  C07F15/00 ,  C07C45/50

CPC分类号： B01J31/2404 ,  B01J31/1855 ,  B01J31/186 ,  B01J31/188 ,  B01J31/20 ,  B01J31/2234 ,  B01J2231/321 ,  B01J2531/0266 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/845 ,  C07C45/50 ,  C07F9/46 ,  C07F9/572 ,  C07F15/008 ,  C07C47/02

摘要： Provided are a catalyst composition including a transition metal catalyst and a nitrogen-containing bidentate phosphorus compound and a process for hydroformylation reaction of olefins to prepare aldehydes which includes stirring the catalyst composition, an olefin compound, and a gas mixture of of carbon monoxide and hydrogen, under high temperature and pressure condition. Therefore, very high catalytic activity and high selectivity in normal-aldehyde or iso-aldehyde according to the type of a substiuent are ensured.

公开(公告)号：EP2580201A2

公开(公告)日：2013-04-17

申请号：EP11736154.3

申请日：2011-06-10

申请人： Rhodes Technologies

发明人： GIGUERE, Joshua, R. ,  MCCARTHY, Keith, E. ,  REISCH, Helge, A. ,  SANDOVAL, Sergio ,  STYMIEST, Jake, L.

IPC分类号： C07D265/30

CPC分类号： C07D489/08 ,  B01J23/42 ,  B01J23/44 ,  B01J31/1855 ,  B01J31/20 ,  B01J31/2295 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/64 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07C209/00 ,  C07C209/44 ,  C07C269/04 ,  C07D265/30 ,  C07D295/03 ,  C07D295/205 ,  Y02P20/55 ,  C07C211/21 ,  C07C271/12

摘要： The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

摘要翻译： 本公开提供了用于第三cardamines的N-脱烷基化和使用的过渡金属催化剂的制备叔N-烯丙基胺衍生物和它们的仲胺衍生物的方法。 第三cardamines可以是生物碱，更具体地，第三cardamines可以是阿片样物质。 在具体的实施方案中，本公开提供了在使用过程中用于从东罂粟碱纳洛酮和纳曲酮的合成方法。

公开(公告)号：EP1558384A1

公开(公告)日：2005-08-03

申请号：EP03750375.2

申请日：2003-09-26

申请人： Studiengesellschaft Kohle mbH

发明人： REETZ, Manfred, T. ,  SELL, Thorsten ,  MEISWINKEL, Andreas ,  MEHLER, Gerlinde

IPC分类号： B01J31/18 ,  B01J23/46 ,  C07F9/50 ,  C07F15/00 ,  C07F19/00 ,  C07F9/6571 ,  B01J31/24 ,  C07B53/00

CPC分类号： B01J31/185 ,  B01J23/464 ,  B01J31/1845 ,  B01J31/1855 ,  B01J31/1865 ,  B01J31/187 ,  B01J31/24 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/321 ,  B01J2231/323 ,  B01J2231/325 ,  B01J2231/326 ,  B01J2231/327 ,  B01J2231/342 ,  B01J2231/348 ,  B01J2231/4211 ,  B01J2231/4238 ,  B01J2231/4255 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2231/72 ,  B01J2531/0266 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07B53/00 ,  C07C67/303 ,  C07C231/12 ,  C07F9/46 ,  C07F9/5022 ,  C07F9/52 ,  C07F9/6568 ,  C07F9/65683 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/65842 ,  C07F9/65844 ,  C07F9/65848 ,  Y10S502/506 ,  C07C69/34 ,  C07C233/05 ,  C07C233/13 ,  C07C233/18

摘要： The invention relates to certain chiral transition metal catalysts, to the metal of which at least two structurally different monophosphorus ligands are bonded, at least one of said monophosphorus ligands being chiral. Said chiral transition metal catalysts are suitable as catalysts for use in asymmetric transition metal-catalyzed reactions, providing better enantioselectivities than in cases where only one structurally defined ligand is used.

公开(公告)号：EP1448575A1

公开(公告)日：2004-08-25

申请号：EP02792844.9

申请日：2002-11-30

申请人： Eidgenössische Technische Hochschule (ETH) Zürich

发明人： DEBLON, Stephan ,  GRÜTZMACHER, Hansjörg ,  MAIRE, Pascal, Felix ,  SCHÖNBERG, Hartmut

IPC分类号： C07F9/553 ,  C07F9/48 ,  C07F9/50 ,  C07F9/58 ,  C07F9/572 ,  C07F9/6568 ,  C07F9/6584 ,  C07F9/6571 ,  C07F15/00 ,  C07F15/06 ,  B01J31/24 ,  C07C43/196 ,  C07C43/192 ,  C07C49/755 ,  C07C209/52 ,  C07C233/12 ,  C07C5/03 ,  C07C5/05 ,  C07F7/08

CPC分类号： B01J31/2447 ,  B01J31/1855 ,  B01J31/187 ,  B01J31/188 ,  B01J31/2295 ,  B01J31/2419 ,  B01J31/2438 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/82 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/845 ,  B01J2531/847 ,  C07B2200/07 ,  C07C5/03 ,  C07C17/16 ,  C07C209/52 ,  C07C231/12 ,  C07C231/18 ,  C07C253/30 ,  C07C303/08 ,  C07C303/38 ,  C07C303/40 ,  C07C2531/22 ,  C07C2601/18 ,  C07C2603/32 ,  C07F7/0829 ,  C07F9/4883 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/5535 ,  C07F9/5721 ,  C07F9/582 ,  C07F9/587 ,  C07F9/65683 ,  C07F9/65719 ,  C07F9/65844 ,  C07F15/0033 ,  C07F15/006 ,  C07F15/0073 ,  C07F15/0086 ,  C07F15/06 ,  C07C309/86 ,  C07C311/16 ,  C07C311/29 ,  C07C25/22 ,  C07C255/47 ,  C07C23/18 ,  C07C211/48 ,  C07C13/26 ,  C07C233/05

摘要： The invention relates to novel phosphorus compounds, to a method for producing said phosphorus compounds and their intermediate products. The invention also relates to the catalysts produced according to the invention on the basis of the phosphorus compounds and to their use in catalytic processes, especially in asymmetric catalytic processes.

摘要翻译： 本发明涉及新型磷化合物，涉及一种生产所述磷化合物及其中间产物的方法。 本发明还涉及根据本发明生产的基于磷化合物的催化剂及其在催化方法中的用途，特别是在不对称催化方法中。

公开(公告)号：EP0888364A1

公开(公告)日：1999-01-07

申请号：EP97908576.0

申请日：1997-03-07

申请人： DSM N.V. ,  E.I. DU PONT DE NEMOURS AND COMPANY

发明人： SNIJDER, Carina, Sacha ,  TEUNISSEN, Antonius, Jacobus, Josephus, Maria ,  HANSEN, Carolina, Bernedette ,  SHAPIRO, Rafael ,  GARNER, James, Michael

IPC分类号： B01J31 ,  C07B61 ,  C07C45 ,  C07C47 ,  C07C51 ,  C07C67 ,  C07C69 ,  C07F9

CPC分类号： C07F9/146 ,  B01J31/185 ,  B01J31/1855 ,  B01J2231/321 ,  B01J2531/822 ,  C07C51/14 ,  C07C67/347 ,  C07F9/145 ,  C07C69/716

摘要： Process to prepare a multidentate phosphite compound according to general formula (1) in which n is 2-6, R is an n-valent organic group and R?1 and R2¿ are fused aromatic ring systems with 2 or more rings, which rings are substituted on the ortho position relative to the oxygen atom only with hydrogen, by first preparing a phosphorochloridite compound from a R1-OH and R2-OH alcohol compound and a phosphorus chloride compound and subsequently contacting the phosphorochloridite compound with an alcoholic compound according to R-(OH)¿n?, wherein the phosphorochloridite is prepared by performing the two steps in a solvent: a) contacting a compound with general formula (2) in which R?3 and R4¿ are C¿1?-C4 alkyl groups, with the R?1¿OH and R2OH compounds and b) contacting the resulting compound of step (a) which has formula (3) with HY, wherein Y represents a halogen atom.

公开(公告)号：EP2995614B1

公开(公告)日：2018-01-31

申请号：EP15186900.5

申请日：2011-06-10

申请人： Rhodes Technologies Inc.

发明人： GIGUERE, Joshua, R. ,  MCCARTHY, Keith, E. ,  REISCH, Helge, A. ,  SANDOVAL, Sergio ,  STYMIEST, Jake, L.

IPC分类号： C07D265/30 ,  C07D489/08 ,  C07C209/00 ,  C07C269/04

CPC分类号： C07D489/08 ,  B01J23/42 ,  B01J23/44 ,  B01J31/1855 ,  B01J31/20 ,  B01J31/2295 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/64 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07C209/00 ,  C07C209/44 ,  C07C269/04 ,  C07D265/30 ,  C07D295/03 ,  C07D295/205 ,  Y02P20/55 ,  C07C211/21 ,  C07C271/12

摘要： The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.

公开(公告)号：EP2580201B1

公开(公告)日：2017-08-02

申请号：EP11736154.3

申请日：2011-06-10

申请人： Rhodes Technologies

发明人： GIGUERE, Joshua, R. ,  MCCARTHY, Keith, E. ,  REISCH, Helge, A. ,  SANDOVAL, Sergio ,  STYMIEST, Jake, L.

IPC分类号： C07D265/30

CPC分类号： C07D489/08 ,  B01J23/42 ,  B01J23/44 ,  B01J31/1855 ,  B01J31/20 ,  B01J31/2295 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/64 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07C209/00 ,  C07C209/44 ,  C07C269/04 ,  C07D265/30 ,  C07D295/03 ,  C07D295/205 ,  Y02P20/55 ,  C07C211/21 ,  C07C271/12

公开(公告)号：EP1325013B1

公开(公告)日：2006-09-13

申请号：EP01950115.4

申请日：2001-07-06

申请人： DSM IP Assets B.V.

发明人： BERG VAN DEN, Michel ,  MINNAARD, Adriaan, Jacobus ,  FERINGA, Ben ,  VRIES DE, Johannes, Gerardus

IPC分类号： C07F15/00 ,  C07F9/6571 ,  B01J31/18 ,  C07B53/00 ,  C07H9/02

CPC分类号： C07F15/0073 ,  B01J31/1855 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/303 ,  C07F9/657154 ,  C07F15/0046 ,  C07C69/34

摘要： Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a ligand, a ranges from 0.5 to 3 and b anc c, each independently, range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms, R?1 and R2¿ each independently represent H, an optionally substituted alkyl, aryl, alkaryl or aralkyl group or may form a (heterocyclic) ring together with the N-atom to which they are bound. And a process for the asymmetric (transfer) hydrogenation of an olefinically unsaturated compound, ketone, imine or oxime derivate in the presence of a hydrogen donor and of a catalyst, use being made of a catalyst represented by formula ML¿a?XbSc, where M is a transition metal, to be chosen from rhodium, iridium and ruthenium, X I a counter ion, S is a ligand, a ranges from 0.5 to 3 and b and c range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms; and R?1 and R2¿ are as defined above.