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公开(公告)号：EP3210971B1
公开(公告)日：2019-10-16
申请号：EP15853036.0
申请日：2015-10-22
发明人： BANNO, Yoshihiro , KAMAURA, Masahiro , TANIGUCHI, Takahiko , TAKAMI, Kazuaki , FUKUDA, Koichiro , SASAKI, Shigekazu
IPC分类号： C07D207/08 , A61K31/40 , A61P27/02 , A61P43/00 , C12N15/09 , A61K31/401
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公开(公告)号：EP3210973A1
公开(公告)日：2017-08-30
申请号：EP15853151.7
申请日：2015-10-22
IPC分类号： C07D213/65 , A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , A61P27/02
CPC分类号： A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , C07D213/65 , C07D231/12 , C07D231/22 , C07D239/34 , C07D263/38 , C07K14/47 , C12N15/09
摘要： Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
A compound represented by the formula (I):
wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.摘要翻译： 本发明提供一种具有优异的RBP4降低作用的杂环化合物，可用作预防或治疗RBP4或由RBP4供给的视黄醇增加介导的疾病或症状的药物。 由式（I）表示的化合物或其盐：其中各符号如说明书中所定义，或其盐具有优异的RBP4降低作用，并且可用作预防或治疗由以下介导的疾病或症状的药物： 由RBP4提供的RBP4或视黄醇的增加。
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公开(公告)号：EP4063349A1
公开(公告)日：2022-09-28
申请号：EP20891142.0
申请日：2020-11-18
IPC分类号： C07D207/14 , C07D207/22
摘要： The present invention provides a production method suitable for industrial production of (2S,3S)-3-amino-2-(3-bromo-2-fluorobenzyl)pyrrolidine having a protecting group at the 1-position.
The present invention is a method for producing N-[(4-methylphenyl)sulfonyl]-L-phenylalanine salt of (2S,3S)-3-amino-2-(3-bromo-2-fluorobenzyl)pyrrolidine having a protecting group at the 1-position, which comprises
Step 2: a step of subjecting 2-(3-bromo-2-fluorobenzyl)-3-(methoxyimino)pyrrolidine having a protecting group at the 1-position to a reduction reaction; and
Step 3: a step of subjecting the product obtained in Step 2 to optical resolution using salt formation with N-[(4-methylphenyl)sulfonyl]-L-phenylalanine.-
公开(公告)号：EP3239142A1
公开(公告)日：2017-11-01
申请号：EP15873198.4
申请日：2015-12-24
发明人： SASAKI, Minoru , KIKUCHI, Fumiaki , IKEDA, Zenichi , KAKEGAWA, Keiko , NISHIKAWA, Yoichi , SASAKI, Shigekazu , FUKUDA, Koichiro , TAKAMI, Kazuaki , BANNO, Yoshihiro , KAMAURA, Masahiro
IPC分类号： C07D313/00 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/662 , A61P3/04 , A61P3/10 , A61P43/00 , C07D313/20 , C07D321/00 , C07D321/12 , C07D323/00 , C07D405/06 , C07D409/12 , C07D491/044 , C07D493/04 , C07D495/04 , C07F9/655
CPC分类号： C07D495/04 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/662 , C07D313/00 , C07D313/20 , C07D321/00 , C07D321/12 , C07D323/00 , C07D405/06 , C07D409/12 , C07D413/06 , C07D491/044 , C07D493/04 , C07F9/655
摘要： The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].
摘要翻译： 本发明涉及具有肠肽酶抑制作用，可用于肥胖症，糖尿病等的治疗或预防的缩合杂环化合物及含有其的药物。 具体而言，本发明涉及由下式（I）表示的化合物或其盐，以及含有其的药物[式中，各符号如说明书中所定义]。
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公开(公告)号：EP2210876B1
公开(公告)日：2015-05-20
申请号：EP08844600.0
申请日：2008-10-31
发明人： BANNO, Yoshihiro , HARA, Ryoma , TOKUNOH, Ryosuke
IPC分类号： C07D207/20 , A61K31/341 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/4155 , A61K31/4439 , A61P3/10 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/36 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/06 , C07D409/04 , C07D413/04
CPC分类号： C07D207/20 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/36 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/06 , C07D409/04 , C07D413/04
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公开(公告)号：EP3848353A1
公开(公告)日：2021-07-14
申请号：EP20210993.0
申请日：2015-10-22
IPC分类号： C07D213/65 , A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , A61P27/02
摘要： Provided is a medicament for use in the treatment of a disease mediated by an increase in RBP4 or retinol supplied by RBP4 which is an ophthalmic disease.
This medicament comprises a compound represented by the formula (I):
wherein each symbol is as defined in the claims.-
公开(公告)号：EP2838891B1
公开(公告)日：2017-08-02
申请号：EP13710076.4
申请日：2013-02-22
发明人： TAKAKURA, Nobuyuki , BANNO, Yoshihiro , TERAO, Yoshito , OCHIDA, Atsuko , MORIMOTO, Sachie , KITAMURA, Shuji , TOMATA, Yoshihide , YASUMA, Tsuneo , IKOMA, Minoru , MASUDA, Kei
IPC分类号： C07D333/60 , C07D407/14 , C07D417/12 , C07D495/04 , C07D307/82 , A61K31/381 , A61K31/343 , A61K31/4355 , A61K31/4365 , A61P3/04
CPC分类号： C07D333/60 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/84 , C07D333/54 , C07D333/64 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D495/04
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公开(公告)号：EP2210876A1
公开(公告)日：2010-07-28
申请号：EP08844600.0
申请日：2008-10-31
发明人： BANNO, Yoshihiro , HARA, Ryoma , TOKUNOH, Ryosuke
IPC分类号： C07D207/20 , A61K31/341 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/4155 , A61K31/4439 , A61P3/10 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/36 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/06 , C07D409/04 , C07D413/04
CPC分类号： C07D207/20 , C07D307/42 , C07D307/52 , C07D333/16 , C07D333/36 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/06 , C07D409/04 , C07D413/04
摘要： The present invention provides a heterocyclic compound represented by the following formula (I), which has a glucagon antagonistic action and is useful for the prophylaxis or treatment of diabetes and the like, a compound represented by
wherein ring A is an optionally substituted benzene ring and the like; Y is a nitrogen atom and the like; X is -O- and the like; R 4 is a hydrogen atom and the like; R 5 and R 6 are each independently a hydrogen atom and the like; R 1 is an optionally substituted hydrocarbon group and the like; R 2 is a hydrogen atom and the like; and R 3 is -(CH 2 ) 3 -COOH and the like, or a salt thereof.摘要翻译： 本发明提供由下式（I）表示的杂环化合物，其具有胰高血糖素拮抗作用，可用于预防或治疗糖尿病等，其中环A为任选取代的苯环表示的化合物和 类似; Y是氮原子等; X是-O-等; R 4是氢原子等; R 5和R 6各自独立地为氢原子等; R 1是任选取代的烃基等; R 2是氢原子等; R 3为 - （CH 2）3 -COOH等，或其盐。
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公开(公告)号：EP3816154A1
公开(公告)日：2021-05-05
申请号：EP19826282.6
申请日：2019-06-27
发明人： FUJIMOTO, Tatsuhiko , FUKUDA, Koichiro , SUGIMOTO, Hiromichi , RIKIMARU, Kentaro , BANNO, Yoshihiro , MATSUMOTO, Takahiro , TOKUNAGA, Norihito , TOMATA, Yoshihide , ISHICHI, Yuji , MARUI, Shogo , ODA, Tsuneo , MIYAZAKI, Tohru , HOASHI, Yasutaka , HATTORI, Yasushi , KAJITA, Yuichi , MIYANOHANA, Yuhei , KOIKE, Tatsuki
IPC分类号： C07D211/56 , A61K31/445 , A61K31/506 , A61P25/00 , A61P25/20 , A61P43/00 , C07D401/14 , C07D405/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：EP3210973B1
公开(公告)日：2020-12-02
申请号：EP15853151.7
申请日：2015-10-22
IPC分类号： C07D213/65 , A61K31/415 , A61K31/421 , A61K31/4418 , A61K31/505 , A61P27/02
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