公开(公告)号：EP4353321A2

公开(公告)日：2024-04-17

申请号：EP24159394.6

申请日：2015-07-31

申请人： OncoTherapy Science, Inc.

发明人： TSUNODA, Takuya ,  OSAWA, Ryuji ,  YAMASHITA, Sachiko ,  WATANABE, Tomohisa ,  HIKICHI, Tetsuro

IPC分类号： A61P35/00

CPC分类号： C07K14/4743 ,  A61P35/00 ,  A61K39/0011 ,  A61K2039/57220130101 ,  A61K2039/515420130101 ,  A61K38/00 ,  A61K35/15 ,  A61K9/0019 ,  A61K9/19 ,  A61K9/107 ,  C12N5/0638 ,  C12N2502/112120130101 ,  A61K39/00

摘要： The present invention provides KOC1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：EP2678353B1

公开(公告)日：2018-12-05

申请号：EP12705682.8

申请日：2012-02-24

申请人： INSERM - Institut National de la Santé et de la Recherche Médicale

发明人： GODEAU, Jean-François ,  LE BOUC, Yves

IPC分类号： C07K14/47 ,  C12Q1/37

CPC分类号： A61K38/30 ,  C07K14/4743 ,  C07K14/71 ,  C07K16/2863 ,  G01N33/74 ,  G01N2333/65

摘要： The present invention provides polypeptide derivatives of IGFBP-3 that are resistant to proteolytic cleavage. These IGFBP-3 derivatives are useful in a variety of therapeutic and diagnostic applications. Also provided are pharmaceutical compositions and kits comprising such IGFBP-3 derivatives and methods for using these derivatives for the treatment of a variety of disorders.

公开(公告)号：EP2799546B1

公开(公告)日：2017-07-12

申请号：EP12862230.5

申请日：2012-05-09

申请人： Korea Institute of Radiological & Medical Sciences

发明人： KIM, Kwang Seok ,  BAE, Sang Woo ,  CHOI, Kyu Jin ,  KIM, Eun Sook

IPC分类号： C12N15/11 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C12Q1/6881 ,  C07K2/00 ,  C07K14/4743 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/4745 ,  G01N2333/71 ,  G01N2800/40

公开(公告)号：EP2646463B1

公开(公告)日：2016-06-29

申请号：EP11791737.7

申请日：2011-12-01

申请人： F.Hoffmann-La Roche AG

发明人： LOBITO, Adrian ,  OUYANG, Wenjun ,  GONZALEZ, Lino, C., JR.

IPC分类号： C07K14/65 ,  C07K14/705 ,  C07K16/22 ,  C07K16/28

CPC分类号： C07K16/2878 ,  C07K14/4743 ,  C07K14/65 ,  C07K14/70578 ,  C07K2317/76 ,  C07K2319/00

公开(公告)号：EP2799546A1

公开(公告)日：2014-11-05

申请号：EP12862230.5

申请日：2012-05-09

申请人： Korea Institute of Radiological & Medical Sciences

发明人： KIM, Kwang Seok ,  BAE, Sang Woo ,  CHOI, Kyu Jin ,  KIM, Eun Sook

IPC分类号： C12N15/11 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C12Q1/6881 ,  C07K2/00 ,  C07K14/4743 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/4745 ,  G01N2333/71 ,  G01N2800/40

摘要： The present invention provides: a composition for radiation exposure diagnosis including an agent for measuring an expression level of an insulin-like growth factor-binding protein-5 (IGFBP-5) gene at an mRNA or the protein; a kit for radiation exposure diagnosis including the composition; a method of diagnosing radiation exposure by measuring the expression level of the IGFBP-5 gene at an mRNA or the protein in a patient's sample; a method of screening an agent for enhancing radiation sensitivity by selecting a sample having increased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a method of screening an agent for radiation protection by selecting a sample having decreased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a composition for enhancing radiation sensitivity including an agonist to expression or action of the IGFBP-5 gene at an mRNA or the protein; and a composition for radiation protection including an antagonist to expression or action of the IGFBP-5 gene at an mRNA or the protein.

摘要翻译： 本发明提供：用于治疗辐射暴露诊断包括对胰岛素样生长的表达水平的测量的试剂的组合物因子结合蛋白5（IGFBP-5）基因在mRNA或蛋白质; 用于治疗辐射暴露诊断包含所述组合物的试剂盒; 通过测量mRNA或向患者的样品中的蛋白的IGFBP-5基因的表达水平诊断辐射曝光的方法; 筛选基因的方法用于通过选择在与mRNA或相比，这些对照组中的蛋白质具有IGFBP-5的增加的表达水平的样品增强辐射敏感性的试剂; 通过选择在与mRNA或相比，这些对照组中的蛋白质具有IGFBP-5的减少的表达水平的样品筛选基因辐射防护的试剂的方法; 一种用于增强辐射敏感性的包含激动剂在mRNA或蛋白质表达或IGFBP-5基因的作用的组合物; 和辐射防护的组合物包含拮抗剂表达或IGFBP-5基因的作用在mRNA或蛋白质的。

公开(公告)号：EP2678353A1

公开(公告)日：2014-01-01

申请号：EP12705682.8

申请日：2012-02-24

申请人： INSERM - Institut National de la Santé et de la Recherche Médicale

发明人： GODEAU, Jean-François ,  LE BOUC, Yves

IPC分类号： C07K14/47

CPC分类号： A61K38/30 ,  C07K14/4743 ,  C07K14/71 ,  C07K16/2863 ,  G01N33/74 ,  G01N2333/65

摘要： The present invention provides polypeptide derivatives of IGFBP-3 that are resistant to proteolytic cleavage. These IGFBP-3 derivatives are useful in a variety of therapeutic and diagnostic applications. Also provided are pharmaceutical compositions and kits comprising such IGFBP-3 derivatives and methods for using these derivatives for the treatment of a variety of disorders.

摘要翻译： 本发明提供对蛋白水解切割具有抗性的IGFBP-3的多肽衍生物。 这些IGFBP-3衍生物可用于各种治疗和诊断应用。 还提供了包含这种IGFBP-3衍生物的药物组合物和试剂盒以及使用这些衍生物用于治疗各种疾病的方法。

公开(公告)号：EP1953229A3

公开(公告)日：2008-12-24

申请号：EP07023337.4

申请日：1999-10-14

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Giese, Klaus

IPC分类号： C12N15/12 ,  C12N15/10

CPC分类号： C12N9/0053 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4711 ,  C07K14/4722 ,  C07K14/4743 ,  C07K14/4748 ,  C07K14/52 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7055 ,  C07K14/72 ,  C07K14/8121 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/104 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Gene sequences as shown in SEQ ID NOS: 1 to 85 have been found to be significantly associated with metastatic potential of cancer cells, especially breast and colon cancer cells. Methods are provided for determining the risk of metastasis of a tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS: 1 to 85, or a substantial portion thereof.

公开(公告)号：EP1718965A2

公开(公告)日：2006-11-08

申请号：EP05722953.6

申请日：2005-02-09

申请人： Munin Corporation

发明人： LAU, Lester, F.

IPC分类号： G01N33/00 ,  A01K67/00

CPC分类号： A01K67/0275 ,  A01K67/0276 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  C07K14/4743 ,  C12N15/8509

摘要： The invention describes transgenic animals with a heterozygous mutation of the CCN1 gene and animal models for treatments for atrioventricular septal defects.

公开(公告)号：EP1435986A4

公开(公告)日：2006-01-11

申请号：EP02759330

申请日：2002-08-09

申请人： BIOEXPERTISE LLC

发明人： MASCARENHAS DESMOND

IPC分类号： A61K45/00 ,  A61K31/138 ,  A61K31/337 ,  A61K31/495 ,  A61K31/513 ,  A61K31/519 ,  A61K31/675 ,  A61K31/7008 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/00 ,  A61K38/04 ,  A61K38/30 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K7/08 ,  C07K14/47

CPC分类号： C07K14/4743 ,  A61K38/30

摘要： New compositions based on IGF-binding protein sequences are provided. New tools for high-throughput research are provided. New methods for the treatment of human disease are provided. IGFBP-3-derived peptide or small molecule is administered to subjects having disease, thereby alleviating the symptoms of the disease.

摘要翻译： 提供了基于IGF-结合蛋白质序列的新组合物。 提供了高通量研究的新工具。 提供了治疗人类疾病的新方法。 将IGFBP-3衍生的肽或小分子给予患有疾病的受试者，从而减轻疾病的症状。

公开(公告)号：EP1465909A2

公开(公告)日：2004-10-13

申请号：EP02792441.4

申请日：2002-12-17

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： RECHLER, Mathew, M.

IPC分类号： C07H21/02 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/00 ,  C12N5/00 ,  A61K38/28 ,  A61K39/00 ,  A01N43/04

CPC分类号： C07K14/4743 ,  A61K38/00

摘要： An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human insulin growth factor-I (IGF-I), nor human insulin growth factor-II (IGF-II), and comprises a mutation at Y57; a vector comprising the same, a cell comprising and expressing the same, optionally in the form of a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human IGF-I nor human IGF-II and comprises a mutation at Y57; a composition comprising the same; and a method of inducing apoptosis in a cell, which method comprises administering to the cell the nucleic acid molecule or polypeptide molecule, in an amount sufficient to induce apoptosis in the cell, whereupon apoptosis is induced in the cell.