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公开(公告)号：EP4375668A3
公开(公告)日：2024-08-14
申请号：EP24164321.2
申请日：2018-11-16
发明人： MELTON WITT, Jody , SON, Sodany , BAUMEISTER, Mark , BERRY, Jody
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49 , C12N5/10 , G01N33/543
CPC分类号： A61K39/12 , C07K14/005 , C07K2319/0220130101 , C07K2319/3020130101 , C07K2319/4020130101 , C07K2319/7320130101 , C12N2740/1612220130101 , C12N2740/1613420130101
摘要： Various embodiments of the invention relate to polypeptides comprising 1-10 or more epitopes of the HIV envelope protein and a fusion protein, wherein the polypeptide lacks the transmembrane domain of the HIV gp41 protein. Such polypeptides may be expressed in mammalian cells, such as human cells, to produce, for example, polypeptides that are useful in developing novel anti-HIV antibodies. Polypeptides described herein and novel antibodies developed therefrom are generally useful for medical diagnostics, and they may also be useful in the prophylactic and therapeutic treatment of HIV.
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公开(公告)号：EP4429697A1
公开(公告)日：2024-09-18
申请号：EP22813992.9
申请日：2022-11-07
申请人： AvenCell Europe GmbH
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公开(公告)号：EP4353819A3
公开(公告)日：2024-07-17
申请号：EP23218163.6
申请日：2005-07-22
IPC分类号： C07K16/00 , A01K67/027 , C12N5/10
CPC分类号： C07K16/00 , C07K16/1054 , C07K16/1063 , C07K16/1232 , C07K2317/2220130101 , C07K2317/3120130101 , C07K2317/5320130101 , C07K2317/56920130101 , C07K2319/0020130101 , C07K2317/6420130101 , C07K16/241 , A61P1/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P3/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , C07K16/30 , C07K2319/7320130101
摘要： The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions.
The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.-
公开(公告)号：EP3693397B1
公开(公告)日：2024-06-12
申请号：EP19220077.2
申请日：2014-07-11
IPC分类号： C07K16/46 , A61K39/395 , C07K14/505 , C07K14/535 , C07K14/575 , C07K14/61 , C07K14/435 , C07K14/705 , A61K47/65 , A61K47/68 , A61P1/00 , A61P3/00 , A61P5/00 , A61P7/06 , A61P9/00 , A61P11/00 , A61P25/04 , A61P35/00 , A61P37/00
CPC分类号： A61K39/395 , C07K14/505 , C07K14/535 , C07K14/57563 , C07K14/5759 , C07K16/2866 , C07K14/43522 , C07K2317/56520130101 , C07K2317/9220130101 , C07K2319/0020130101 , C07K14/61 , C07K14/70503 , C07K16/1027 , C07K2318/1020130101 , C07K2319/5020130101 , C07K2319/7320130101 , A61K47/65 , A61K47/6889 , C07K16/32 , A61K2039/50520130101 , A61P1/00 , A61P1/04 , A61P1/06 , A61P11/00 , A61P25/04 , A61P3/00 , A61P3/04 , A61P35/00 , A61P3/06 , A61P37/02 , A61P37/06 , A61P5/00 , A61P7/06 , A61P9/04 , A61P9/12 , A61P3/10 , C07K16/468
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公开(公告)号：EP3504225B1
公开(公告)日：2024-04-24
申请号：EP18808514.6
申请日：2018-11-16
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49 , C12N5/10 , G01N33/543
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公开(公告)号：EP4353819A2
公开(公告)日：2024-04-17
申请号：EP23218163.6
申请日：2005-07-22
IPC分类号： C12N5/10
CPC分类号： C07K16/00 , C07K16/1054 , C07K16/1063 , C07K16/1232 , C07K2317/2220130101 , C07K2317/3120130101 , C07K2317/5320130101 , C07K2317/56920130101 , C07K2319/0020130101 , C07K2317/6420130101 , C07K16/241 , A61P1/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P3/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , C07K16/30 , C07K2319/7320130101
摘要： The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions.
The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.-
7.发明公开
公开(公告)号：EP4441212A1
公开(公告)日：2024-10-09
申请号：EP22902447.6
申请日：2022-12-05
申请人： Cornell University
发明人： PASZEK, Matthew , PARK, Sangwoo
CPC分类号： C12N9/88 , C12Y402/02001 , C12N9/2402 , C12Y302/01018 , C07K2319/0320130101 , C07K2319/7320130101 , C07K14/7051 , A61K35/17 , C12N9/13 , C12Y208/02008 , A61K38/51 , A61K38/47 , A61K35/15
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公开(公告)号：EP4423117A1
公开(公告)日：2024-09-04
申请号：EP22799963.8
申请日：2022-10-24
申请人： Autolus Limited
发明人： RIGHI, Matteo , CORDOBA, Shaun , PULÉ, Martin
IPC分类号： C07K14/725 , A61P35/00 , A61P37/06 , C07K14/705 , C07K14/715
CPC分类号： C07K14/7155 , C07K14/70596 , C07K2319/7320130101 , C07K2319/7020130101 , C07K2319/0020130101 , C07K2319/0320130101 , A61P35/00 , C07K14/7051 , A61P37/06
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公开(公告)号：EP4183412B1
公开(公告)日：2024-08-14
申请号：EP22200670.2
申请日：2010-07-15
IPC分类号： A61K39/155 , C07K14/135 , C07K16/10
CPC分类号： A61K39/00 , A61K39/155 , A61K2039/525820130101 , A61K2039/5320130101 , A61K2039/5550520130101 , A61K2039/5555520130101 , A61K2039/5556120130101 , A61K2039/5557220130101 , C07K14/005 , C07K16/1027 , C07K2319/0020130101 , C07K2319/2120130101 , C07K2319/5020130101 , C07K2319/7320130101 , C12N2760/1852220130101 , C12N2760/1853420130101 , C07K2317/7620130101 , A61K2039/525220130101 , A61K2039/525620130101 , A61K2039/5556620130101 , C12N2770/3614320130101 , A61K39/12 , A61P11/00 , A61P31/14 , A61P37/04
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公开(公告)号：EP4405387A1
公开(公告)日：2024-07-31
申请号：EP22789444.1
申请日：2022-09-23
申请人： Seagen Inc.
发明人： LEVENGOOD, Matthew
IPC分类号： C07K16/00 , C12N15/13 , A61K39/395
CPC分类号： C07K16/00 , C07K2317/9420130101 , C07K2319/5020130101 , C07K2319/7320130101
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