HYDROXYALKYL ALKYL CELLULOSE, METHOD FOR PRODUCING THE SAME, AND SOLID PREPARATION
    1.
    发明公开
    HYDROXYALKYL ALKYL CELLULOSE, METHOD FOR PRODUCING THE SAME, AND SOLID PREPARATION 审中-公开
    羟烷基烷基纤维素,其制备方法和固体制剂

    公开(公告)号:EP3309179A1

    公开(公告)日:2018-04-18

    申请号:EP17195310.2

    申请日:2017-10-06

    IPC分类号: C08B11/193

    摘要: There is provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, provided are a hydroxyalkyl alkyl cellulose having a volume-based average particle diameter, determined by dry laser diffractometry, of 50 to 100 µm, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles and fibrous particles, a volume fraction of the fibrous particles consisting of long and short fibrous particles relative to all of the particles of 45 to 70%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.

    摘要翻译: 提供了显示良好流动性和高可压缩性的羟烷基烷基纤维素。 更具体而言,提供通过干式激光衍射法测定的体积基准平均粒径为50〜100μm的羟烷基烷基纤维素,并且基于动态图像分析将全部颗粒分成细颗粒,球形 颗粒和纤维状颗粒,由相对于所有颗粒的长和短纤维颗粒组成的纤维状颗粒的体积分数为45-70%,并且细颗粒相对于所有颗粒的体积分数小于2.0% ; 包含羟烷基烷基纤维素的固体制剂; 和别的。

    CHEMICAL MODIFICATION OF SHAPED HYDROGELS IN NON-AQUEOUS MEDIUM
    5.
    发明公开
    CHEMICAL MODIFICATION OF SHAPED HYDROGELS IN NON-AQUEOUS MEDIUM 失效
    在水介质水凝胶制品的化学修饰

    公开(公告)号:EP0750638A1

    公开(公告)日:1997-01-02

    申请号:EP95931031.0

    申请日:1995-08-29

    IPC分类号: C08B3 C08B5 C08B7 C08B11 C08B13

    CPC分类号: C08B3/00 C08B3/14

    摘要: A method is described for the chemical modification of pre-shaped hydrogels in non-aqueous medium. The conditions permit the reaction of highly expanded, porous hydrogel particles, such as spherical beads, using pseudo homogeneous reaction conditions in the absence of water. The method involves a three step procedure in which the porous gels are solvent exchanged into a water-free solvent (step 1) with minimal change in gel dimension and porosity; followed by reaction under non-aqueous condition (step 2); and followed by solvent exchange into water (step 3). Many different types of reactions requiring non-aqueous conditions may be carried out using these conditions. The method has particularly been demonstrated for crosslinking fluorinating beads, and for esterifying beads in a reaction involving multifunctional free carboxylic acids in the presence of dicyclohexylcarbodiimide (DCC).

    LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION
    10.
    发明公开
    LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION 审中-公开
    低取代羟丙基纤维素及其生产方法和固体制剂

    公开(公告)号:EP3308775A1

    公开(公告)日:2018-04-18

    申请号:EP17195312.8

    申请日:2017-10-06

    IPC分类号: A61K9/20 C08B11/193

    摘要: Provided are low-substituted hydroxypropyl cellulose (L-HPC) having a hydroxypropoxy content of from 5 to 16% by weight, and having, on a basis of a dynamic image analysis to divide all particles into fine, spherical, and fibrous particles consisting of long and short fibrous particles, a volume fraction of the long fibrous particles of from 15 to 50% and a volume fraction of the short fibrous particles of from 23 to 60%; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps: bringing sheet-like or chip-like pulp having a length-weighted average fiber length of from 2.40 to 3.50 mm into contact with an alkali metal hydroxide solution, reacting the resulting alkali cellulose with propylene oxide, and dispersing the resulting reaction product in water containing an acid to partially dissolve it therein, followed by neutralization with an acid to precipitate crude L-HPC.

    摘要翻译: 提供羟基丙氧基含量为5-16重量%的低取代羟丙基纤维素(L-HPC),并且基于动态图像分析将所有颗粒分成由以下物质组成的细颗粒,球状和纤维状颗粒: 长短纤维颗粒,长纤维颗粒的体积分数为15〜50%,短纤维颗粒的体积分数为23〜60%; 和含有L-HPC的固体制剂。 还提供了一种生产L-HPC的方法,包括以下步骤:使长度加权平均纤维长度为2.40-3.50mm的片状或碎片状纸浆与碱金属氢氧化物溶液接触,使得到的产物 将碱性纤维素与环氧丙烷混合,并将所得反应产物分散在含有酸的水中以部分溶解于其中,随后用酸中和以沉淀粗制L-HPC。