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    METHOD FOR PRODUCING AROMATIC COMPOUND AND DERIVATIVE THEREOF
    1.
    发明公开
    METHOD FOR PRODUCING AROMATIC COMPOUND AND DERIVATIVE THEREOF 审中-公开

    公开(公告)号：EP3342874A1

    公开(公告)日：2018-07-04

    申请号：EP16839312.2

    申请日：2016-08-24

    申请人： RIKEN

    发明人： NODA Shuhei ,  SHIRAI Tomokazu

    IPC分类号： C12P7/22 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12P7/40 ,  C12P7/42 ,  C12P13/22 ,  C12N15/09

    CPC分类号： C12P13/225 ,  C12N15/09 ,  C12P7/22 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P13/001 ,  C12P13/22

    摘要： The present invention provides a method for producing an aromatic compound such as salicylic acid and a derivative thereof with high productivity using a microorganism. The present invention provides: a method for producing a microorganism having a sugar metabolic pathway modified, including suppressing the expression of a gene encoding a phosphotransferase system enzyme of the microorganism, suppressing the expression of a gene encoding pyruvate kinase of the microorganism, and introducing, into the microorganism, one or more genes encoding an enzyme that enables the microorganism to synthesize an aromatic compound from chorismic acid or isochorismic acid; a modified microorganism obtained by the method; and a method for producing an aromatic compound and a derivative thereof, including culturing the microorganism, and recovering an aromatic compound or the like from the culture.

    METHOD FOR PRODUCING CHEMICAL BY MEANS OF CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION DEVICE
    2.
    发明公开
    METHOD FOR PRODUCING CHEMICAL BY MEANS OF CONTINUOUS FERMENTATION AND CONTINUOUS FERMENTATION DEVICE 有权
    用于生产化学品，通过连续发酵和装置用于实现连续发酵

    公开(公告)号：EP2837687A1

    公开(公告)日：2015-02-18

    申请号：EP13770154.6

    申请日：2013-03-27

    申请人： Toray Industries, Inc.

    发明人： KANAMORI, Satoko ,  SAWAI, Hideki ,  TAKEUCHI, Norihiro

    IPC分类号： C12P13/04 ,  C12M1/00 ,  C12P7/56 ,  C12P13/02 ,  C12R1/01 ,  C12R1/13 ,  C12R1/15 ,  C12R1/19 ,  C12R1/43

    CPC分类号： C12P13/24 ,  C12M29/04 ,  C12M33/14 ,  C12M41/34 ,  C12P7/56 ,  C12P13/001 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/222 ,  C12P13/225 ,  C12P13/227

    摘要： Provided is a method of producing a chemical by a continuous fermentation method in which a washing effect of a separation membrane by a gas is enhanced by a simple operation procedure and high productivity can be stably maintained for a long time. The method of producing a chemical of the present invention includes: a chemical production step of culturing cells to ferment a feedstock to produce a chemical; a culture solution supply step of supplying a culture solution containing the chemical to a separation membrane unit; a filtration step of filtering the culture solution to separate a permeate containing the chemical; a reflux step of refluxing a retentate that is not filtered to the fermentor; and a washing step of supplying a gas containing oxygen to the separation membrane unit while the amount is changed to at least two different values to perform scrubbing, wherein the supply amount and time of the gas containing oxygen supplied in the chemical production step and the washing step are set so that a kLa value is within a predetermined range from an optimal kLa value for the cells cultured in the chemical production step.

    摘要翻译： 提供的是生产通过连续发酵方法，其中，分离膜的由气体的洗涤作用是通过一个简单的操作过程和高的生产率提高的化学的方法可以稳定地保持很长时间。 制造本发明的化学品的方法，包括：培养细胞发酵原料以产生一种化学的化学品生产工序; 供给含有化学的分离膜单元的培养液的培养液的供给步骤; 过滤所述培养液中分离的渗透物含有化学的过滤步骤; 回流一滞留物的回流的步骤并没有被过滤到发酵罐中; 和供给含有气体的氧分离膜单元，而量变为至少两个不同的值来执行洗涤，worin在化学生产步骤和洗涤供给的含有气体的氧的供给量和时间的洗涤步骤 步骤是这样设定做了起亚值是从在化学生产步骤中培养的细胞最佳起亚值在预定范围内。

    Method for producing L-3,4-dihydroxyphenylalanine
    9.
    发明公开
    Method for producing L-3,4-dihydroxyphenylalanine 失效
    Verfahren zur Herstellung von L-3,4-二羟基苯丙氨酸。

    公开(公告)号：EP0636695A1

    公开(公告)日：1995-02-01

    申请号：EP94111423.3

    申请日：1994-07-21

    申请人： Ajinomoto Co., Inc.

    发明人： Kotani, Takuya, c/o Kawasaki Plant, Ajinomoto Co. ,  Lizumi, Katsuo, c/o Kawasaki Plant, Ajinomoto Co. ,  Takeuchi, Makoto ,c/o Kawasaki Plant,Ajinomoto Co.

    IPC分类号： C12P13/22

    CPC分类号： C12P13/225 ,  Y10S435/847

    摘要： In a method for producing L-3,4-dihydroxyphenylalanine by subjecting microorganism cells having a β-tyrosinase activity or a product to be obtained by processing them to catalytic reaction with catechol, pyruvic acid and ammonium ion or with catechol and L-serine, the reaction is continued at a temperature lower than 25°C under the condition where anhydrous crystals of L-3,4-dihydroxyphenylalanine exist in the reaction mixture while L-3,4-dihydroxyphenylalanine being formed are made precipitated as anhydrous crystals in the reaction mixture, and the thus-precipitated anhydrous crystals are collected.
    According to the method of the present invention, crude crystals of L-3,4-dihydroxyphenylalanine having a high purity may be obtained at a high yield of recovery, by simple means.

    摘要翻译： 在通过使β-酪蛋白酶活性的微生物细胞或通过加工它们得到的产物与儿茶酚，丙酮酸和铵离子或与儿茶酚和L-丝氨酸进行催化反应来制备L-3,4-二羟基苯丙氨酸的方法中， 反应在低于25℃的温度下，在反应混合物中存在着L-3,4-二羟苯丙氨酸的无水结晶，而形成的L-3,4-二羟基苯丙氨酸在反应中作为无水晶体析出 混合，收集如此沉淀的无水晶体。 根据本发明的方法，可以通过简单的手段以高回收率获得具有高纯度的L-3,4-二羟基苯丙氨酸的粗晶体。