公开(公告)号：EP2917362A4

公开(公告)日：2016-07-13

申请号：EP13853032

申请日：2013-11-07

申请人： SANDSTONE DIAGNOSTICS INC

发明人： SCHAFF ULRICH ,  SOMMER GREG ,  TOMKINS-TINCH CHRISTOPHER

IPC分类号： C12Q1/06 ,  C12Q1/02 ,  G01N33/48

CPC分类号： B04B5/0407 ,  B04B9/10 ,  C12Q1/06 ,  G01N15/042 ,  G01N2015/0065 ,  G01N2015/045 ,  G01N2015/055

公开(公告)号：EP2485049B1

公开(公告)日：2014-12-03

申请号：EP12154103.1

申请日：2012-02-06

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： Hyde, David D. ,  LaCourt, Michael W. ,  McDonald, Tracy ,  Parobek, Christopher M.

IPC分类号： G01N33/49 ,  G01N35/10

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G01N35/1009 ,  G01N2015/055

摘要： A method for determining a condition in a blood sample includes: providing a sample of blood; providing a metering probe having a pump for aspirating and dispensing; inserting the metering probe a selected distance into the blood sample; measuring the pressure between the sample and pump during sample aspiration or sample dispense; comparing the measured pressure with a reference value; and signaling the presence or absence of the condition. A method for confirming or detecting the presence of a selected layer of blood component in a centrifuged blood sample includes: measuring a pressure of a suspected selected layer in a metering probe during aspiration or dispense; comparing the measured pressure with a reference value, wherein if the measured pressure and the reference value are substantially identical then the selected layer of the blood component is confirmed. In a preferred embodiment the reference value is a pre-selected pressure range. Blood components include packed red blood cells (PRBC) or plasma.

公开(公告)号：EP2485049A3

公开(公告)日：2013-04-10

申请号：EP12154103.1

申请日：2012-02-06

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： Hyde, David D. ,  LaCourt, Michael W. ,  McDonald, Tracy ,  Parobek, Christopher M.

IPC分类号： G01N33/49 ,  G01N35/10

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N33/491 ,  G01N35/1009 ,  G01N2015/055

摘要： A method for determining a condition in a blood sample includes: providing a sample of blood; providing a metering probe having a pump for aspirating and dispensing; inserting the metering probe a selected distance into the blood sample; measuring the pressure between the sample and pump during sample aspiration or sample dispense; comparing the measured pressure with a reference value; and signaling the presence or absence of the condition. A method for confirming or detecting the presence of a selected layer of blood component in a centrifuged blood sample includes: measuring a pressure of a suspected selected layer in a metering probe during aspiration or dispense; comparing the measured pressure with a reference value, wherein if the measured pressure and the reference value are substantially identical then the selected layer of the blood component is confirmed. In a preferred embodiment the reference value is a pre-selected pressure range. Blood components include packed red blood cells (PRBC) or plasma.

公开(公告)号：EP2464959A1

公开(公告)日：2012-06-20

申请号：EP10808551.5

申请日：2010-08-05

申请人： Siemens Healthcare Diagnostics Inc.

发明人： MILLER, Kerry, L.

IPC分类号： G01N21/00

CPC分类号： G01N15/042 ,  G01N15/05 ,  G01N21/25 ,  G01N35/00603 ,  G01N2015/045 ,  G01N2015/055

摘要： A method of inspecting a clinical specimen for a presence of one or more interferents, such as those that might be found within clinical analytical blood specimens by subjecting the specimen to centrifugation to separate the specimen into a red blood cell portion and a blood serum or plasma portion is provided. Subsequent to the centrifuging procedure, the serum or plasma portion of the clinical analytical specimen may be tested for the presence of one or more interferents such as hemolysis, icterus, lipemia, or liquid nonuniformities therein. Additionally, physical dimensional characteristics of the sample container and/or specimen may be determined. Apparatus for carrying out the method are described, as are other aspects.

公开(公告)号：EP1434637B1

公开(公告)日：2006-02-08

申请号：EP02774618.9

申请日：2002-09-14

申请人： Roche Diagnostics GmbH ,  F. HOFFMANN-LA ROCHE AG

发明人： EFFENHAUSER, Carlo ,  OCVIRK, Gregor ,  FIEDLER, Wolfgang

IPC分类号： B01D1/00

CPC分类号： G01N15/05 ,  A61M1/3693 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  G01N33/491 ,  G01N2015/055 ,  G01N2015/1486 ,  Y10T436/25 ,  Y10T436/25375

摘要： The invention relates to a method for the separation of particles from a dispersion, in particular for the separation of corpuscular components from biological samples, in particular, from blood. A separating module, suitable for carrying out said method, comprises a substrate (5) with flow channels (3), including a feed channel (9) for the supply of the dispersion to a branching (10), a first discharge channel (11), for leading fluid with reduced particle concentration away from the branching (10) and a second drainage channel (12), for leading fluid with increased particle concentration away from the branching (10). The fluid flows into the second drainage channel so much quicker than into the first drainage channel (12) that the particles at the branching (10) preferably flow into the second drainage channel (12) as a result of the differing flow speeds.

公开(公告)号：EP1373854A2

公开(公告)日：2004-01-02

申请号：EP02707072.1

申请日：2002-03-19

申请人： Inflamet Ltd. ,  Berliner, Shlomo

发明人： BERLINER, Shlomo

IPC分类号： G01N1/00

CPC分类号： G06T7/0012 ,  G01N15/05 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/491 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/0092 ,  G01N2015/055 ,  G01N2015/1465 ,  G01N2015/1486 ,  G01N2015/1497 ,  G06K9/0014 ,  G06T2207/30024

摘要： A system for generating a profile of particulate components of a body fluid sample is provided. The system includes: (a) a device for causing controlled flow of the body fluid sample on a substrate, the controlled flow of the body fluid sample leading to a differential distribution of the particulate components on the substrate; and (b) a magnifying device being for providing a magnified image of differentially distributed particulate components on the substrate, the magnified image representing a profile of the particulate components of the body fluid sample.

公开(公告)号：EP0813086B1

公开(公告)日：2002-07-31

申请号：EP97108539.4

申请日：1997-05-27

申请人： Levine, Robert Aaron ,  Wardlaw, Stephen Clark

发明人： Levine, Robert Aaron ,  Wardlaw, Stephen Clark

IPC分类号： G02B21/34 ,  G01N15/05

CPC分类号： B01L3/5021 ,  G01N33/491 ,  G01N2015/055 ,  G02B21/34 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

公开(公告)号：EP0813086A2

公开(公告)日：1997-12-17

申请号：EP97108539.4

申请日：1997-05-27

申请人： Levine, Robert Aaron ,  Wardlaw, Stephen Clark

发明人： Levine, Robert Aaron ,  Wardlaw, Stephen Clark

IPC分类号： G02B21/34

CPC分类号： B01L3/5021 ,  G01N33/491 ,  G01N2015/055 ,  G02B21/34 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： Centrifuged anticoagulated blood samples are analyzed under magnification in a centrifuge tube containing a layer-elongating insert, which tube is placed on a calibrated slide. The slide includes a slot in which the tube is placed. A calibrated scale is disposed adjacent to the slot for use in measuring various blood sample parameters, such as hematocrit, platelet count, and the like. Anemia and/or low platelet counts are indicative of potentially serious complications of malaria. Their detection will prompt a physician to consider the liklihood of serious illness due to malaria. The presence or absence of blood-borne parasites can also be determined using the procedures of this invention. Thus the device allows a blood sample to be analyzed for malaria parasites, and also allows measurement of hematicrit and platelet counts. The scale can be presented in a normal image when a simple lens magnification, such as a magnifying glass, is used to view the tube and slide; and can also be presented in mirror image when compound lens magnification, such as a microscope, is used to view the tube and slide.

摘要翻译： 将离心的抗凝血液样品在放置在含有延伸层的插入物的离心管中进行分析，该管放置在校准的载玻片上。 滑动件包括其中放置管的狭槽。 校准的刻度尺设置在与狭槽相邻的位置，用于测量各种血液样本参数，例如血细胞比容，血小板计数等。 贫血和/或低血小板计数表明疟疾潜在严重并发症。 他们的检测将促使医生考虑疟疾引起的严重疾病的可能性。 血源性寄生虫的存在或不存在也可以使用本发明的程序来确定。 因此，该装置允许血液样品被分析疟疾寄生虫，并且还允许测量血液和血小板计数。 当使用诸如放大镜的简单透镜倍率来观察管和滑动时，标度可以呈现在正常图像中; 并且当使用复合透镜放大倍率（例如显微镜）来观察管和滑动时也可以以镜像呈现。

公开(公告)号：EP0231652A3

公开(公告)日：1988-11-23

申请号：EP86310092

申请日：1986-12-23

申请人： BAXTER TRAVENOL LABORATORIES, INC.

发明人： KARKAR, MAURICE N. ,  LONG, WARREN M. ,  HEINEMANN, STAN O.

IPC分类号： G01N33/49 ,  G01N15/05 ,  G01N21/03 ,  G01N21/05 ,  G01N21/35 ,  G01N21/53 ,  G01N21/85 ,  G01N21/47 ,  G01N21/51 ,  G01N33/48 ,  G01N33/72

CPC分类号： G01N21/05 ,  G01N21/35 ,  G01N21/53 ,  G01N21/85 ,  G01N2015/055 ,  G01N2021/0367 ,  G01N2201/0621

摘要： The hematocrit of a volume of blood can be determined in real time without volume or flow rate limitations by sensing the diffusion of infrared light by the bloodstream. For this purpose, an in­ frared light beam is directed at a transparent cuvette (12) through which the blood is conveyed, and a photodetector is mounted beside the cuvette at an angle such that the intersection of the light beam and of the principal sensitivity lobe of the de­ tector is wholly spaced from the multiple scatter zone adjacent to the light source. The hematocrit signal produced by the photodetector (40) can be corrected for the effect of oxygen saturation by providing an oxygen saturation signal, multiplying the hematocrit signal by a function of the oxygen saturation signal and using a look-up table to derive a linear true hematocrit signal. Means are also provided to compen­ sate the detected hematocrit signal for the effects of temperature, drive current, and aging.

公开(公告)号：EP3408641A1

公开(公告)日：2018-12-05

申请号：EP17744779.4

申请日：2017-01-24

申请人： Siemens Healthcare Diagnostics Inc.

发明人： KLUCKNER, Stefan ,  CHANG, Yao-Jen ,  CHEN, Terrence ,  POLLACK, Benjamin, S.

IPC分类号： G01N1/10 ,  G01N21/03 ,  G01N21/95 ,  G01B11/245 ,  G06T3/00 ,  G06T7/00

CPC分类号： G01N35/00732 ,  G01B11/245 ,  G01F23/00 ,  G01N15/042 ,  G01N35/1016 ,  G01N2015/047 ,  G01N2015/055 ,  G01N2035/0401 ,  G01N2035/0406 ,  G01N2035/0493 ,  G01N2035/1018 ,  G01N2035/1025 ,  G06T5/009 ,  G06T5/50 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/143 ,  G06T7/62 ,  G06T2207/10024 ,  G06T2207/10036 ,  G06T2207/10144 ,  G06T2207/10152 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/20208 ,  G06T2207/20221

摘要： A model-based method of classifying a specimen in a specimen container. The method includes capturing images of the specimen and container at multiple different exposures times, at multiple different spectra having different nominal wavelengths, and at different viewpoints by using multiple cameras. From the captured images, 2D data sets are generated. The 2D data sets are based upon selection of optimally-exposed pixels from the multiple different exposure images to generate optimally-exposed image data for each spectra. Based upon these 2D data sets, various components are classified using a multi-class classifier, such as serum or plasma portion, settled blood portion, gel separator (if present), tube, air, or label. From the classification data and 2D data sets, a 3D model can be generated. Specimen testing apparatus and quality check modules adapted to carry out the method are described, as are other aspects.