公开(公告)号：EP2192412B1

公开(公告)日：2017-05-03

申请号：EP09177280

申请日：2009-11-26

Applicant: F HOFFMANN-LA ROCHE AG ,  ROCHE DIAGNOSTICS GMBH

Inventor： BURKARD DANIEL

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  B01J19/006 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2035/1058

Abstract: The present invention pertains to a system for the automated processing of fluids according to a process operation plan involving the use of preloaded objects, said process operation plan defining preloaded objects to be present in target object positions, said system comprising: a processing area in which objects to be used for the processing of fluids are located; at least one ultrasonic sensor, adapted for determining the presence of objects by means of acoustical waves; a positioning device to which the ultrasonic sensor is fixed, adapted to move the ultrasonic sensor in at least one direction relative to said processing area; a control computer being configured to determine the presence of objects and determining if objects are present in target object positions in said processing area as defined by said process operation plan; a pipetting device for pipetting of fluids between cavities located in said processing area; an analytical or pre-analytical processing device for processing of fluids located in said processing area.

Abstract translation: 本发明涉及用于流体雅鼎的自动处理的系统的工艺操作计划涉及使用预加载的对象的方法，所述方法运行计划限定预加载的对象存在于targetObject位置，所述系统包括：其中的处理区 要用于的流体位于处理对象; 至少一个超声传感器，angepasst确定性采矿通过声波的方式的存在对象; 到的超声波传感器被固定的定位装置，angepasst移动超声波传感器相对于所述处理区域中的至少一个方向上; 控制计算机被配置为确定矿对象，如果对象是存在于所述处理区targetObject位置由所述处理操作计划所定义的确定性采矿的存在; 对位于所述处理区域的腔之间的流体进行移液的吸移装置; 在对位于所述加工区域的流体的处理分析或预分析处理装置。

公开(公告)号：EP2981391A4

公开(公告)日：2017-03-08

申请号：EP14778524

申请日：2014-03-19

Applicant: ABON BIOHPARM (HANGZHOU) CO LTD

Inventor： ZHANG JINGLIU ,  YANG KANG

IPC: B23Q7/16 ,  B07B13/00 ,  B07C5/04 ,  B65G47/256 ,  G01B21/02 ,  G01B21/04 ,  G01N33/487 ,  G01N33/53 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01B21/08 ,  B07B13/003 ,  G01N33/4875 ,  G01N2035/00108 ,  G01N2035/0465 ,  G01N2035/0494

公开(公告)号：EP2856150A4

公开(公告)日：2016-01-27

申请号：EP13794585

申请日：2013-05-21

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS

Inventor： MELLARS COLIN ,  YAGCI BARIS ,  POLLACK BENJAMIN SAMUEL

IPC: G01N33/48 ,  G01N35/00 ,  G01N35/04 ,  G05D1/02

CPC classification number: G01N35/04 ,  B01J19/0093 ,  B01L3/54 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2035/00772 ,  G01N2035/00792 ,  G01N2035/00831 ,  G01N2035/0406 ,  G01N2035/0432 ,  G01N2035/0467 ,  G01N2035/0489 ,  G01N2035/0491 ,  G01N2035/0494 ,  G05D1/0234 ,  G05D2201/0216 ,  Y10T436/115831

Abstract: An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. The intelligent carriers can include one or more image sensors to observe the relative motion of the track as the carrier traverses it. The carriers can also observe position marks on the track surface to provide absolute position information, which can include additional data, such as routing instructions. Synchronization marks may be provided to correct errors in the observed trajectory.

公开(公告)号：EP2795294A1

公开(公告)日：2014-10-29

申请号：EP12857516.4

申请日：2012-12-14

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： MILESKY, Lawrence ,  ZANTOS, George

IPC: G01N21/01

CPC classification number: G01N21/8483 ,  G01B11/14 ,  G01N21/253 ,  G01N21/27 ,  G01N35/00069 ,  G01N35/04 ,  G01N2035/00148 ,  G01N2035/0491 ,  G01N2035/0494 ,  G01N2201/025 ,  G01N2201/0438 ,  G01N2201/06113

Abstract: A reagent card analyzer comprises an optical signal source configured to transmit an optical signal and an optical signal detector spaced a distance from the optical signal source to define an optical signal path into which the optical signal is transmitted, the optical signal detector configured to detect the optical signal and to output an electrical signal indicative of the optical signal. A reader is configured to read a reagent pad of a reagent card. A reagent card moving mechanism is configured to move the reagent card having the reagent pad including a leading and trailing end through the optical signal path. An optical detector interface is electrically coupled with the optical signal detector and configured to receive electrical signals and to output a pad detect signal indicative of at least one of the leading and the trailing end as the reagent card is moved through the optical signal path.

Abstract translation: 试剂卡分析仪包括光信号源和光信号检测器，所述光信号源被配置为发送光信号，所述光信号检测器与所述光信号源隔开一段距离，以限定光信号被发送到的光信号路径，所述光信号检测器被配置为检测 光信号并输出​​表示光信号的电信号。 读取器被配置为读取试剂卡的试剂垫。 试剂卡移动机构被配置为通过光信号路径移动具有包括前端和后端的试剂垫的试剂卡。 光学检测器接口与光学信号检测器电耦合，并被配置为接收电信号并且当试剂卡移动通过光学信号路径时输出指示前端和后端中的至少一个的焊盘检测信号。

公开(公告)号：EP2693218A1

公开(公告)日：2014-02-05

申请号：EP13176709.7

申请日：2013-07-16

Applicant: Tecan Trading AG

Inventor： Eckard, Simon M. ,  Ingenhoven, Nikolaus

IPC: G01N35/00 ,  B01L9/02 ,  G01N35/04

CPC classification number: G01N35/00613 ,  B01L9/02 ,  B01L99/00 ,  G01N35/00732 ,  G01N2035/00772 ,  G01N2035/00801 ,  G01N2035/0091 ,  G01N2035/0493 ,  G01N2035/0494

Abstract: Das Erfassen der ursprünglichen Anordnung von Laborartikeln (1) auf einem Arbeitsfeld (2) einer Labor-Arbeitsstation (3) erfolgt mittels mit einer Digitalkamera (5) aufgenommenen und abgespeicherten Referenz-Digitalbildern (6). Beim Anzeigen eines solchen Referenz-Digitalbilds (6) werden erfindungsgemäss Bereiche auf dem Arbeitsfeld (2) der Labor-Arbeitsstation (3) mit charakteristischen auf dem mindestens einen Referenz-Digitalbild (6) sichtbaren Merkmalen (10) von einem Benutzer mit einem Eingabegerät (11) ausgewählt und markiert. Anschliessend werden Referenz-Bildausschnitte (12) und deren Referenz-Bildparameter-Dateien (13) erzeugt und abgespeichert. Ein Überprüfungsverfahren vergleicht die aktuelle Anordnung von Laborartikeln (1) auf diesem Arbeitsfeld (2) mit einer zuvor erfassten, ursprünglichen Anordnung von Laborartikeln (1) und umfasst das Erfassen dieser aktuellen Anordnung mittels mit einer Digitalkamera (5) aufgenommenen aktuellen Digitalbildern (6'), zudem das Laden von verarbeiteten Referenz-Bildausschnitten (12') sowie das Laden der entsprechenden Referenz-Bildparameter-Dateien (13) in den Speicher (7) eines Rechners (8) und das Erstellen von aktuellen, durch X/Y-Parameter der Referenz-Bildparameter-Dateien (13) definierten Bildausschnitten (14) aus den aktuellen Digitalbildern (6'). Das Überprüfungs-Verfahren umfasst vorzugsweise zudem einen computerbasierten Vergleich der verarbeiteten aktuellen Bildausschnitte 14' mit den verarbeiteten Referenz-Bildausschnitten 12', eine Analyse dieses Vergleichs und die Anzeige von Übereinstimmungen, Abweichungen und Fehlern der aktuellen Anordnung gegenüber der ursprünglichen Anordnung von Laborartikeln 1 auf dem Arbeitsfeld 2 der Labor-Arbeitsstation 3.

Abstract translation: 该方法包括标识和与特征，参考数字图像在其上是可见的生产参照图像的部分。 所述特征从一组“实验室制品（10工作场的特征（10），”“），并附加标记（10”）中选择E.G. 公司徽标。 的输入装置（11）被用于标记所述参考图像部分。 参照图像参数文件产生用于所产生的参考图像片段。 所产生的参考图像部分和所生产的参照图像参数文件存储在存储器（7）。 因此独立权利要求中包括了以下内容：在实验室工作站（2）实验室工作站的工作领域上实验室制品的装置检查（1）的方法。

公开(公告)号：EP2601504A1

公开(公告)日：2013-06-12

申请号：EP11815314.7

申请日：2011-08-04

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： ROSMARIN, Matthew, Anthony ,  FILLER, Vadim ,  THOMAS, Neil, Simon ,  PERLMAN, Adam, Justin ,  CREAZZO, Thomas

IPC: G01N1/00

CPC classification number: B65G1/04 ,  B25J9/1612 ,  B65B5/08 ,  G01N35/0099 ,  G01N2035/0494

Abstract: Disclosed are methods and systems adapted to aid in a handling of sample containers (e.g., sample containers) in a processing or testing system. The method includes a sequence of motions of gripper fingers and a seater to accomplish a pick and place operation of a sample container where the sample container includes a sticky surface. A sample container positioning system is disclosed, as are other aspects.

公开(公告)号：EP1564542A1

公开(公告)日：2005-08-17

申请号：EP04016610.0

申请日：2004-07-14

Applicant: Hitachi, Ltd.

Inventor： Tanabata, Takanari c/o Hitachi Ltd. New Marunouchi ,  Shinomura, Tomoka c/o Hitachi Ltd. New Marunouchi ,  Ishizuka, Toru ,  Kanetomo, Masafumi c/o Hitachi Ltd. New Marunouchi

IPC: G01N21/13 ,  G01N35/02 ,  G06T7/00 ,  A01G7/00 ,  A01G9/00 ,  G01N21/25

CPC classification number: G06T7/0012 ,  A01G7/00 ,  G01N21/13 ,  G01N21/253 ,  G01N2035/0494 ,  G06K9/00

Abstract: There are provided an image acquisition system capable of storing high-accuracy measurement of changes in the shape of a plant growing process in image information with high accuracy and an analyzing method for analyzing an acquired image to analyze plant growing.
There is provided a plant growing analyzing system having operation detection means (15) of a conveying mechanism (9) of a plant (13) in order that an observed plant in an image is photographed at a constantly fixed position; a position detecting mark (14) in the acquired image; a computation part (16) for evaluating detected data to control a conveying amount; and a conveying control part (10), wherein the growing process of many plants is stored in image information in a long period, and the stored image is used to realize high-accuracy measurement.

Abstract translation: 提供一种图像采集系统，其能够高精度地存储图像信息中植物生长过程的变化的高精度测量，以及用于分析所获取的图像以分析植物生长的分析方法。 提供了具有植物（13）的输送机构（9）的操作检测装置（15）的植物生长分析系统，以便在恒定的位置拍摄图像中的观察植物; 所获取的图像中的位置检测标记（14）; 用于评估检测数据以控制传送量的计算部分（16）; 以及输送控制部（10），其中许多植物的生长过程长时间存储在图像信息中，并且存储的图像用于实现高精度测量。

公开(公告)号：EP1354185A1

公开(公告)日：2003-10-22

申请号：EP01991602.2

申请日：2001-12-31

Applicant: Gilson, Inc. ,  Gilson, Robert E. ,  Norton, Robert

Inventor： GILSON, Robert, E. ,  NORTON, Robert

IPC: G01N1/00

CPC classification number: G01N35/10 ,  G01N35/028 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2035/00237 ,  G01N2035/0494

Abstract: A probe drive system (24) of a precision liquid handler (20) sequentially inserts probe tips (36) of a multiple probe array (30) into a locator well (76) at a known position on a locator bed (28). The position of each probe tip (36) is determined by driving the probe tip (36) into contact with points on the side wall (88) of the locator well (76) and sensing the contacts. The positions of the probe tips (36) are mapped and checked for skew of the probe array (30). The probe tip positions ae overlaid to determine probe tip scatter. If a probe tip (36) is excessively misaligned, it is inserted into the locator well (76) and driven against the side wall (88) to bend the probe and reduce the misalignment of the probe tip (36). The center of the probe tip scatter is determined and is used by the probe drive system (24) as a global correction factor. Probe tips (36) with known positions are inserted into spaced apart locator wells (78,80) to detect skew of the locator bed.

公开(公告)号：EP1336662A2

公开(公告)日：2003-08-20

申请号：EP03250911.9

申请日：2003-02-14

Applicant: NGK INSULATORS, LTD.

Inventor： Kira, Shigeki, Legal Affairs and Intell. Prop Dept ,  Yamada, Kazunari, Legal Affairs and Int. Prop Dept ,  Hirota, Toshikazu, Legal Affairs and Int.Prop Dept ,  Yoshida, Yasuko, Legal Affairs and Int. Prop Dept

IPC: C12Q1/68

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00576 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00702 ,  B01J2219/00722 ,  C40B40/06 ,  G01N2035/00158 ,  G01N2035/0494

Abstract: Technology is disclosed for highly accurate automated execution of processing for alignment of a detection area to a DNA microarray image file and processing for quantitative determination of success/ failure of the alignment during DNA microarray analysis. A probe reactive chip (1) used for the technology comprises a substrate (2); a spot region wherein spots for fixing a probe capable of specifically reacting to a sample marked so as to be optically detectable are formed in a matrix on a surface of the substrate; and a reference pattern area, which is arranged within the spot region or approximate to the spot region, and comprises a plurality of different alignment marks in order to correct misalignment of the spot during analysis of the sample on the surface of the substrate.

Abstract translation: 公开了用于高精度自动执行用于将检测区域与DNA微阵列图像文件对齐的处理的技术，以及用于在DNA微阵列分析期间定量确定取向成功/失败的处理。 用于该技术的探针反应性芯片（1）包括基底（2）; 斑点区域，其中用于固定探针的斑点，其能够特异性地反应标记为可光学检测的样品，在基底的表面上形成基质; 以及布置在斑点区域内或近似于斑点区域的参考图案区域，并且包括多个不同的对准标记，以便在基底表面上的样品分析期间校正斑点的未对准。

公开(公告)号：EP1216406A1

公开(公告)日：2002-06-26

申请号：EP00961354.8

申请日：2000-08-24

Applicant: Large Scale Proteomics Corporation

Inventor： ANDERSON, N., Leigh ,  GOODMAN, Jack ,  LENNON, John

IPC: G01N1/10 ,  G01N35/10 ,  B01L11/00

CPC classification number: G01N35/10 ,  B01L9/54 ,  B01L2200/025 ,  G01N1/22 ,  G01N35/028 ,  G01N2035/0494 ,  G01N2035/1039 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0418 ,  Y10T436/2575

Abstract: An alignment plate (60) is provided with a plurality of holes (61) for guiding a pipette tip toward a sample plate (15) of a MALDI mass spectrometer. Each of the holes is provided with a conical upper contour (63) in order to guide the pipette tip toward a specific location on the sample plate (15). Two companion alignment plates are used in order to overlay two separate arrays of samples on the sample plate. For instance, a first of two alignment plates are used in order to overlay two separate arrays of samples on the sample plate. The first of two alignment plates is formed with a first array of holes so that a first array is deposited onto the sample plate. The second of the two alignment plates is formed with a second array of holes of samples is deposited on the sample plate at locations offset from the first array of samples already on the sample plate.

Abstract translation: 对准板（60）设置有多个孔（61），用于将移液管尖端导向MALDI质谱仪的样品板（15）。 每个孔都设有圆锥形的上部轮廓（63），以便将移液管尖端引向样品板（15）上的特定位置。 为了在样品板上覆盖两个独立的样品阵列，使用了两个伴侣对齐板。 例如，使用两个对齐板中的第一个，以便在样本板上覆盖两个单独的样本阵列。 两个对齐板中的第一个形成有第一阵列孔，使得第一阵列被沉积到样品板上。 两个对准板中的第二个形成有第二阵列的样品孔，该第二阵列的样品阵列沉积在样品板上偏离已经在样品板上的第一样品阵列的位置处。