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    Nucleic acid sequences encoding FMDV proteins capable of associating into a virus-like particle
    2.
    发明公开
    Nucleic acid sequences encoding FMDV proteins capable of associating into a virus-like particle 审中-公开
    核酸编码FMDV蛋白质和可组装成病毒样颗粒

    公开(公告)号：EP1632247A1

    公开(公告)日：2006-03-08

    申请号：EP04020994.2

    申请日：2004-09-03

    申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

    发明人： Enjuanes Sanches, Luis ,  Domingo Solans, Esteban, Dr.

    IPC分类号： A61K39/135

    CPC分类号： G01N33/56983 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2770/20022 ,  C12N2770/32122 ,  G01N2333/09 ,  G01N2333/165

    摘要： The present invention relates to nucleic acids comprising:

    (a) sequences of a replication competent transmissible gastroenteritis virus (TGEV), which sequences encode a TGEV replicase under the control of expression regulatory sequences so that expression of the replicase in a cell containing the nucleic acid will initiate replication of the nucleic acid and thus increase the number of nucleic acids in the cell; and
    (b) sequences encoding one or more proteins of foot and mouth disease virus (FMDV), wherein the one or more proteins are capable of associating into a virus-like particle (VLP) that does not contain any infectious nucleic acid.

    The present invention further relates to vectors, virus particles and host cells comprising these nucleic acids as well as their use for the preparation of pharmaceutical compositions, specifically for the preparation of vaccines.

    摘要翻译： 本发明涉及一种核酸，其包含：（a）一种有复制能力的传染性胃肠炎病毒（TGEV），它们的序列编码表达的调控序列的控制下的TGEV复制酶的序列，例如，在含有该核酸的细胞中的复制酶的表达 将启动核酸的复制，从而提高核酸在细胞中的数量; 和（b）的序列编码口蹄疫病毒（FMDV）的一种或多种蛋白质，worin的一种或多种蛋白质能够关联到病毒样颗粒（VLP）不包含任何传染性核酸确实酸。 本发明还涉及载体，病毒颗粒和宿主细胞，其包括本文的核酸以及它们的药物组合物的制备中使用，特别是用于制备疫苗。

    VIRUS DETECTION DEVICE AND VIRUS DETECTION METHOD
    5.
    发明公开
    VIRUS DETECTION DEVICE AND VIRUS DETECTION METHOD 有权
    Virusnachweisvorrichtung und Virusnachweisverfahren

    公开(公告)号：EP2634580A1

    公开(公告)日：2013-09-04

    申请号：EP11835789.6

    申请日：2011-10-14

    申请人： Tokyo Electron Limited

    发明人： TAMURA, Akitake ,  FUJIHARA, Kaoru ,  SAITO, Misako

    IPC分类号： G01N33/569 ,  G01N33/533 ,  G01N37/00

    CPC分类号： G01N33/56983 ,  G01N15/06 ,  G01N2015/0038 ,  G01N2015/0046 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2333/09 ,  G01N2333/11

    摘要： A virus in the atmosphere can be precisely detected on a real time basis. At a main pipeline 8, a dust removing unit 1, an atomization unit 4, a fluorescence measuring unit 5 in which a laser beam is irradiated, and a suction pump 7 are arranged in this order, and a suctioned air current is generated in the main pipeline 8 through the suction pump 7. Meanwhile, a diffusion unit 3 includes a liquid flow path 35 and a gas flow path 34 formed in parallel to the liquid flow path, and an atmosphere and an aqueous solution containing a fluorescent antibody F pass through the gas flow path 34 and the liquid flow path 35, respectively. The aqueous solution is flown into the atomization unit 4 through a guide passage 40 branched from a branch part that is formed at an outlet side of the flow paths 34 and 35 and discharges the gas and the aqueous solution after separating the gas and the aqueous solution. A mist group is flown into the fluorescence measuring unit 5. Since a fluorescence intensity of the mist M when the virus V exists is higher than a fluorescence intensity when no virus V exists, the virus V can be detected by monitoring the fluorescence intensity.

    摘要翻译： 可以在实时的基础上精确检测大气中的病毒。 在主管8处，依次布置有除尘单元1，雾化单元4，照射激光的荧光测量单元5和抽吸泵7，并且在该管道8中产生吸入的气流 主管道8通过抽吸泵7.同时，扩散单元3包括液体流动通道35和与液体流动通道平行形成的气体流路34，并且含有荧光抗体F的气氛和水溶液通过 气体流路34和液体流路35。 水溶液通过从形成在流路34,35的出口侧的分支部分分支的引导通道40流入雾化单元4，并在气体和水溶液分离后排出气体和水溶液 。 雾组被流入荧光测定单元5.由于存在病毒V时的雾M的荧光强度高于不存在病毒V时的荧光强度，因此可以通过监视荧光强度来检测病毒V.