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公开(公告)号：EP3821021A1
公开(公告)日：2021-05-19
申请号：EP19833604.2
申请日：2019-07-09
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公开(公告)号：EP2751141B1
公开(公告)日：2018-03-21
申请号：EP12827866.0
申请日：2012-08-30
发明人： DAY, Robert , NEUGEBAUER, Witold A. , DORY, Yves
IPC分类号： A61K47/50 , C07K17/02 , A61K38/08 , A61K38/55 , A61P35/00 , C07K7/06 , C12N9/64 , A61K38/00 , A61K45/06
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K45/06 , A61K47/542 , A61K47/60 , Y02A50/469 , Y02A50/475
摘要： It is provided PACE4 inhibitors and their uses for treating infection, cancer. Particularly, it is provided a method or use for the treatment of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the PACE4 inhibitors or the composition disclosed.
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公开(公告)号：EP2776471A1
公开(公告)日：2014-09-17
申请号：EP12827889.2
申请日：2012-08-31
发明人： DAY, Robert , NEUGEBAUER, Witold A. , DORY, Yves
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K45/06 , A61K47/542 , A61K47/60 , Y02A50/469 , Y02A50/475
摘要： It is provided PACE4 inhibitors and their uses for treating infection, cancer. Particularly, it is provided a method or use for the treatment of a cancer in a subject, comprising administering to the subject a therapeutically effective amount of the PACE4 inhibitors or the composition disclosed.
摘要翻译： 提供PACE4抑制剂及其用于治疗感染，癌症的用途。 特别地，提供了用于治疗受试者中的癌症的方法或用途，其包括向受试者施用治疗有效量的PACE4抑制剂或所公开的组合物。
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公开(公告)号：EP1529105B1
公开(公告)日：2012-10-03
申请号：EP03739915.1
申请日：2003-06-30
IPC分类号： A61P7/06 , C12N15/113
CPC分类号： A61K48/00 , A61K38/00 , C07K2319/00 , C12N15/113 , C12N2310/321 , C12N2310/3521
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5.发明授权MATRIPTASE INHIBITORS AND USES THEREOF AGAINST ORTHOMYXOVIRIDAE INFECTIONS 有权MATRIPTASE抑制剂及其抗ORTHOMYXOVIRIDAE感染的用途
公开(公告)号：EP2714716B1
公开(公告)日：2018-04-11
申请号：EP12793674.8
申请日：2012-05-28
IPC分类号： C07K5/11 , A61K31/713 , A61K38/07 , A61K39/42 , A61K9/12 , A61K9/72 , A61P31/14 , A61P31/16 , A61P35/00 , C07K5/10 , C12N9/64 , C07K5/09 , C07K5/072 , C07K5/062 , C07K5/093
CPC分类号： C12N15/1131 , A61K9/0075 , A61K9/0078 , A61K31/427 , A61K31/428 , A61K31/713 , A61K38/00 , A61K38/06 , A61K38/07 , A61K45/06 , A61K2039/505 , C07K5/06026 , C07K5/06095 , C07K5/06104 , C07K5/0817 , C07K5/0819 , C07K5/1019 , C07K16/40 , C07K2317/565 , C07K2317/76 , C12N9/6424 , C12N2310/14 , A61K2300/00 , A61L2300/00
摘要： The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.
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6.发明公开
公开(公告)号：EP3262312A1
公开(公告)日：2018-01-03
申请号：EP16754704.1
申请日：2016-02-25
发明人： PLANTE, Jean-Sébastien , DENNINGER, Marc , CHOUINARD, Patrick , JULIO, Guifré , VIAU, Joel , LAROSE, Pascal
CPC分类号： B25J9/104 , B25J9/0078 , B25J19/068 , F16D37/02 , F16D48/06 , F16D2037/001 , F16D2037/004 , F16D2500/10475 , F16D2500/70426
摘要： A tensioning set comprises an output member. A magnetorheological fluid clutch apparatus is configured to receive a degree of actuation (DOA) and connected to the output member, the magnetorheological fluid clutch apparatus being actuatable to selectively transmit the received DOA through the output member by controlled slippage. A tensioning member is connected to the output member so as to be pulled by the output member upon actuation of the magnetorheological fluid clutch apparatus, a free end of the tensioning member adapted to exert a pulling action transmitted to an output when being pulled by the output member. The tensioning set, or a comparable compressing set, may be used in systems and robotic arms. A method for controlling movements of an output driven by the tensioning set or compressing set is also provided.
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7.发明授权
公开(公告)号：EP2303910B1
公开(公告)日：2016-04-06
申请号：EP09793747.8
申请日：2009-07-06
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , C07K14/811 , C12Q1/37 , G01N2333/96438 , G01N2500/04
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8.发明公开METHOD OF GENERATING LOW-ENERGY SECONDARY ELECTRONS FOR APPLICATIONS IN BIOLOGICAL SCIENCES, RADIOCHEMISTRY, AND CHEMISTRY OF POLYMERS AND PHYSICS OF RADIOTHERAPY 审中-公开方法产生能量POOR二次电子FOR作者放射化学生物科学应用和聚合物的化学治疗和放射治疗的物理原理
公开(公告)号：EP2544814A1
公开(公告)日：2013-01-16
申请号：EP11752785.3
申请日：2011-03-11
CPC分类号： G21K5/00 , A61B18/20 , A61L2/087 , A61N5/0624 , A61N5/10 , A61N2005/1088 , A61N2005/1089
摘要： The present disclosure relates to a method and a system for generating low-energy electrons in a biological material. The biological material is held in position by a support. Laser beam pulses are directed by a focusing mechanism toward a region of interest within the biological material. This generates filaments of low-energy electrons within the region of interest. The method and system may be used for radiotherapy, radiochemistry, sterilization, nanoparticle coating, nanoparticle generation, and like uses.
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公开(公告)号：EP2419534A1
公开(公告)日：2012-02-22
申请号：EP10764023.7
申请日：2010-04-14
IPC分类号： C12Q1/68 , C40B30/04 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57415 , C07K14/47 , C07K14/4711 , C07K14/4726 , C07K14/475 , C07K14/4756 , C07K14/49 , C07K14/521 , C07K14/705 , C07K14/70503 , C07K14/70596 , C07K14/745 , C12N9/0071 , C12N9/16 , C12N9/6491 , C12N9/88 , C12Q1/6886 , C12Q2600/158 , C12Y114/17003 , C12Y301/06 , C12Y403/02005
摘要： The present invention relates to the identification of secreted protein isoforms specific in ovarian cancer and methods for diagnosis or prognosis of ovarian cancer in a subject by detecting the secreted protein isoforms.
摘要翻译： 本发明涉及通过检测分泌蛋白异构体来鉴定卵巢癌特异性分泌蛋白异构体和诊断或预测受试者卵巢癌的方法。
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公开(公告)号：EP4454666A1
公开(公告)日：2024-10-30
申请号：EP23169614.7
申请日：2023-04-24
IPC分类号： A61K51/10 , A61K103/00
摘要： Provided are labeled antibody conjugates for use in a method of diagnosing ALS or monitoring drug therapy and/or progression of ALS by in vivo detecting and tracing misfolded SOD1 by immunoimaging in a subject, compositions and kits comprising said conjugates and methods of in vivo immunoimaging of superoxide dismutase (SOD1) useful as a marker of amyotrophic lateral sclerosis (ALS) or efficacy of drug therapy of ALS in subject using these conjugates. Furthermore, SOD1-antibodies specific for misfolded and/or aggregated SOD1 are provided for use in treatment of bone and/or joint related diseases.
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