公开(公告)号：EP2796148A3

公开(公告)日：2015-02-25

申请号：EP14169154.3

申请日：1999-05-28

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Norwegian Institute of Public Health

发明人： Granoff, Dan M ,  Aaberge, Ingeborg ,  Hanenberg, Bjorn ,  Holst, Johan ,  Raff, Howard

IPC分类号： A61K39/095 ,  A61K39/39 ,  A61K9/127 ,  A61K39/385

CPC分类号： A61K39/095 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55583 ,  A61K2039/6037 ,  Y10S424/831 ,  Y10S424/832

摘要： The present invention is directed to a combination vaccine for Neisseria meningitidis comprising outer membrane proteins from serogroup B and oligosaccharides from serogroup C, and its use for the prevention or treatment of disease.

公开(公告)号：EP2457577A1

公开(公告)日：2012-05-30

申请号：EP11008710.3

申请日：2004-11-24

申请人： Anjin Corporation

发明人： Harrison, Robert J. ,  Vanderspek, Joanna C.

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K39/108 ,  C07K14/34

CPC分类号： C07K14/34 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/01 ,  Y10S424/832

摘要： The present invention relates to a composition comprising a diphtheria toxin (DT) variant, said DT variant comprises an amino acid sequence as recited in SEQ ID NO: 4 with one or more amino acid substitutions or deletions or combinations thereof, wherein at least one amino acid substitution or deletion is made within the regions selected from the group consisting of residues 7-9, 29-31 and 290-292 of SEQ ID NO: 4, and wherein said DT variant has cytotoxicity comparable to that of a DT molecule having a sequence of SEQ ID NO: 4.

摘要翻译： 本发明涉及包含白喉毒素（DT）变体的组合物，所述DT变体包含SEQ ID NO：4所述的氨基酸序列，其具有一个或多个氨基酸取代或缺失或其组合，其中至少一个氨基 在选自SEQ ID NO：4的残基7-9,29-31和290-292的区域内进行酸取代或缺失，并且其中所述DT变体具有与具有 SEQ ID NO：4的序列。

公开(公告)号：EP1648501B1

公开(公告)日：2011-04-06

申请号：EP04766245.7

申请日：2004-07-16

申请人： Intervet International BV

发明人： VERMEIJ, Paul

IPC分类号： A61K39/108 ,  A61K39/112 ,  C07K14/25 ,  C07K14/245

CPC分类号： C07K14/25 ,  A61K39/00 ,  A61K39/0258 ,  A61K39/0283 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/70 ,  C07K14/245 ,  C07K2319/55 ,  Y02A50/474 ,  Y02A50/476 ,  Y10S424/832 ,  Y10S530/825

摘要： The present invention relates to a hybrid bacterial toxin subunit, to a hybrid bipartite bacterial toxin and to nucleic acid molecules comprising a nucleotide sequence encoding such bacterial toxins. Furthermore, the invention relates to vaccines comprising bacterial toxins and to their use in vaccines. Finally, the invention relates to methods for the preparation of such vaccines and to the use of such bacterial toxins for the manufacture of such vaccines.

公开(公告)号：EP1100513B1

公开(公告)日：2007-03-21

申请号：EP99941978.1

申请日：1999-07-29

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： CRONAN, John, E., Jr. ,  PLAPP, Bryce, V. ,  GREENBERG, E., Peter ,  PARSEK, Matthew, R.

IPC分类号： A61K31/70 ,  C12N9/00 ,  C12P21/02 ,  G01N33/50

CPC分类号： C07H19/16 ,  A61K31/7076 ,  C07H19/207 ,  C12Q1/25 ,  Y02A50/473 ,  Y10S424/832

摘要： Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

公开(公告)号：EP1076662A2

公开(公告)日：2001-02-21

申请号：EP99916001.3

申请日：1999-04-27

申请人： Chiron S.P.A.

发明人： RAPPUOLI, Rino ,  GRANDI, Guido

IPC分类号： C07K1/00

CPC分类号： C07K14/005 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  C07K14/22 ,  C07K14/235 ,  C07K14/33 ,  C07K14/34 ,  C07K14/445 ,  C07K2319/00 ,  C12N2730/10122 ,  C12N2760/16222 ,  Y02A50/412 ,  Y10S424/831 ,  Y10S424/832 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/822 ,  Y10S530/825 ,  Y10S530/826

摘要： The invention relates to polyepitope carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.

公开(公告)号：EP0983362A1

公开(公告)日：2000-03-08

申请号：EP98903211.5

申请日：1998-02-11

申请人： Calgene LLC

发明人： RIAZUDDIN, Sheikh

IPC分类号： C12N15/32 ,  C07K14/325 ,  A01N63/00 ,  C12N1/20

CPC分类号： C12R1/075 ,  C07K14/325 ,  Y10S424/832 ,  Y10S530/81 ,  Y10S530/825

摘要： The subject invention concerns novel Bacillus thuringiensis strains containing parasporal proteins with pesticidal properties against whitefly, aphid, jassid, and possibly other sucking insects of agronomic importance, and peptide sequences to these proteins that can be used to obtain structural genes. The spores or crystals of these microbes, or mutants thereof, are useful to control hymenopteran pests in various environments. The genes of the invention can be used to transform various hosts wherein the novel toxic proteins can be expressed.

公开(公告)号：EP0652758B1

公开(公告)日：2000-01-05

申请号：EP93913897.0

申请日：1993-05-17

申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： COLLIER, R., John ,  KILLEEN, Kevin ,  MEKALANOS, John

IPC分类号： C12N15/54 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/31 ,  C07K14/34 ,  C12P21/02 ,  A61K38/45

CPC分类号： A61K39/385 ,  A61K39/05 ,  A61K47/646 ,  A61K2039/6037 ,  C07K14/34 ,  Y10S424/832

摘要： A DNA encoding an immunologically cross-reactive form of diphtheria toxin Fragment A, wherein the codons corresponding to Val-147 and Glu-148 of naturally occurring diphtheria toxin are deleted from the DNA.

公开(公告)号：EP0322115B1

公开(公告)日：1996-03-06

申请号：EP88311133.8

申请日：1988-11-24

申请人： CONNAUGHT LABORATORIES LIMITED

发明人： Klein, Michel Henri ,  Boux, Heather Anne ,  Cockle, Stephen Anthony ,  Loosmore, Sheena May ,  Zealey, Gavin Ross

IPC分类号： C12N15/31 ,  A61K39/10

CPC分类号： C12N15/64 ,  A61K39/00 ,  C07K14/235 ,  C12N15/74 ,  Y10S424/832

公开(公告)号：EP0208375A3

公开(公告)日：1989-04-05

申请号：EP86201160.8

申请日：1986-07-02

申请人： SCLAVO S.p.A.

发明人： Porro, Massimo ,  Costantino, Paolo

IPC分类号： A61K39/116 ,  A61K39/385 ,  C07K15/14

CPC分类号： A61K39/092 ,  A61K39/095 ,  A61K2039/6037 ,  A61K2039/70 ,  Y10S424/831 ,  Y10S424/832

摘要： Glycoproteinic conjugates having trivalent immuno­genic activity obtained by binding, by a covalent bond, to a protein selected among CRM 197, tetanus toxoid, and pertussis toxin, at least an oligosaccharidic hapten derived from the capsular polysaccharide of a gram-posi­tive bacterium and at least an oligosaccharidic hapten derived from the capsular polysaccharide of a gram-nega­tive bacterium, and wherein said oligosaccharidic haptens are previously activated by introducing terminal esters.

公开(公告)号：EP0139555B1

公开(公告)日：1987-01-14

申请号：EP84401720.2

申请日：1984-08-27

申请人： INSTITUT PASTEUR Fondation reconnue d'utilité publique

发明人： Dodin, André ,  Siffert, Odile ,  Le Thuillier, Georgette, née Tchernoff ,  Allard, Patrice

IPC分类号： C07K7/08 ,  A61K37/02 ,  G01N33/569

CPC分类号： C07K14/28 ,  A61K38/00 ,  C07K14/245 ,  Y10S424/832 ,  Y10S435/81 ,  Y10S435/975