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1.发明公开Bioactive substance having antitumor activity, producing strain, production ans use thereof 失效具有生产菌株的抗肿瘤效果生理活性物质，以及它们的制备和用途
公开(公告)号：EP0827968A3
公开(公告)日：1999-11-17
申请号：EP97306879.4
申请日：1997-09-04
发明人： Takazawa, Hidenao
CPC分类号： C12R1/67 , A61K38/00 , C07K14/38 , Y10S435/915
摘要： Asn-linked glycoprotein which has a molecular weight of 32 - 84 kDa, absorbs to Concanavalin A and has antitumour activity, a mixture of such glycoproteins, a microorganism which produces the glycoprotein or mixture. The glycoprotein and mixture can be produced by culturing a microorganism belonging to the genus Aspergillus and isolating the glycoprotein or mixture. The glycoprotein is effective for treatment of solid tumor, ascites tumor, multiple cytoma and oral tumor, and for the suppression of tumors.
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公开(公告)号：EP0654095A1
公开(公告)日：1995-05-24
申请号：EP93918612.0
申请日：1993-08-03
发明人： FULLER, Carl, W.
CPC分类号： B01D57/02 , C12N15/101 , C12Q1/6869 , G01N27/44726 , G01N27/44747 , Y10S435/914 , Y10S435/915 , Y10T436/143333
摘要： A method for electrophoresis of nucleic acid fragments present in the solution which contains an amount, e.g., 0.2 % or more, of a reagent, e.g., glycerol, dithiolthreitol (DTT) and trehalose or other sugars, which interact to form a complex with borate or boric acid. The method includes applying the solution to an electrophoretic gel and electrophoresing those fragments into the gel in the presence of a buffer lacking boric acid, or a derivative thereof, which forms a chelate complex with the reagent and thereby causes distortion of electrophoresis of the fragments in a gel including such a buffer.
摘要翻译： 用于电泳存在于溶液中的核酸片段的方法，所述核酸片段含有一定量例如0.2％或更多的试剂例如甘油，二硫苏糖醇（DTT）和海藻糖或其他糖，其与硼酸盐形成复合物 或硼酸。 该方法包括将溶液应用于电泳凝胶，并在缺乏硼酸的缓冲液或其衍生物存在下将这些片段电泳至凝胶中，所述缓冲液与试剂形成螯合络合物，从而引起片段电泳失真 包含这种缓冲液的凝胶。
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3.发明授权Surface-hydrated porous polyacrylonitrile substrates, such as beads derivatives thereof, process for their preparation, and methods for their use 失效多孔表面的水合由聚丙烯腈作为Perlderivate制成的基材，其制备方法和使用方法的过程。
公开(公告)号：EP0371258B1
公开(公告)日：1995-03-01
申请号：EP89119824.4
申请日：1989-10-25
IPC分类号： C08F8/00
CPC分类号： C08F8/00 , Y10S435/915 , Y10S436/824 , C08F20/44
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4.发明公开Surface-hydrated porous polyacrylonitrile substrates, such as beads derivatives thereof, process for their preparation, and methods for their use 失效表面水合多孔聚丙烯酰基底物，如其珠粒衍生物，其制备方法及其使用方法
公开(公告)号：EP0371258A3
公开(公告)日：1991-11-27
申请号：EP89119824.4
申请日：1989-10-25
IPC分类号： C08F8/00
CPC分类号： C08F8/00 , Y10S435/915 , Y10S436/824 , C08F20/44
摘要： Porous substrates comprising acrylonitrile polymer or copolymer cores and a hydrolyzed surface, with low conversion to amide groups and substantially no formation of imide or carboxyl groups on said surface. The substrates and functionalized derivatives thereof, are useful in highly selective chromatographic separations.
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5.发明公开Monoclonal antibodies to purified hepatitis c virus envelope proteins for diagnostic and therapeutic use 失效针对丙型肝炎病毒的纯化的包膜蛋白用于诊断和治疗目的的单克隆抗体
公开(公告)号：EP1845108A2
公开(公告)日：2007-10-17
申请号：EP07109345.4
申请日：1995-07-31
申请人： Innogenetics N.V.
IPC分类号： C07K16/10 , C12N5/10 , C07K14/18 , A61K39/29 , G01N33/569
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to monoclonal antibodies to purified recombinant HCV envelope proteins. During isolation of the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent; this is followed by a step preventing reformation of disulphide bridges. The present invention also relates to the diagnostic and therapeutic application of these monoclonal antibodies.
摘要翻译： 本发明涉及一种单克隆抗体与纯化的重组HCV包膜蛋白。 在重组过量表达的蛋白质二硫键裂解或还原步骤用二硫键裂解剂，进行分离; 这是通过防止二硫键的重整步骤紧随其后。 因此，本发明涉及单克隆抗体合成的诊断和治疗应用。
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6.发明授权PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE 失效CLEAN丙型肝炎病毒包膜蛋白用于诊断和治疗用途
公开(公告)号：EP0721505B2
公开(公告)日：2006-05-10
申请号：EP95930434.6
申请日：1995-07-31
申请人： Innogenetics N.V.
IPC分类号： C12N15/40 , C07K14/18 , C07K16/10 , C12Q1/70 , G01N33/569
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
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7.发明公开Recombinant vectors for producing HCV envelope proteins 失效Rekombinante Vektoren zur Herstellung von HCVHüllproteinen
公开(公告)号：EP1211315A1
公开(公告)日：2002-06-05
申请号：EP02003643.0
申请日：1995-07-31
申请人： Innogenetics N.V.
IPC分类号： C12N15/40 , C12N5/10 , C07K14/18 , A61K39/29 , G01N33/569
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to a recombinant vectors encoding an HCV envelope E1 and/or E2 and/or E1/E2 protein encoding sequence. The invention also relates to recombinant nucleic acids comprising said HCV protein encoding sequences. The invention further relates to host cells transformed with said recombinant vectors, as well as recombinant HCV proteins expressed by said host cells and use thereof in diagnostic methods or kits or therapeutic or prophylactic methods of treatment of HCV or HCV vaccine compositions.
摘要翻译： 本发明涉及编码HCV包膜E1和/或E2和/或E1 / E2蛋白编码序列的重组载体。 本发明还涉及包含所述HCV蛋白编码序列的重组核酸。 本发明还涉及用所述重组载体转化的宿主细胞以及由所述宿主细胞表达的重组HCV蛋白及其在诊断方法或试剂盒中的用途或治疗或预防HCV或HCV疫苗组合物的方法。
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8.发明公开PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE 失效CLEAN丙型肝炎病毒包膜蛋白用于诊断和治疗用途
公开(公告)号：EP0721505A1
公开(公告)日：1996-07-17
申请号：EP95930434.0
申请日：1995-07-31
申请人： INNOGENETICS N.V.
IPC分类号： G01N33 , A61K38 , A61K39 , A61P1 , A61P31 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
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9.发明公开Monoclonal antibodies to purified hepatitis c virus envelope proteins for diagnostic and therapeutic use 失效针对丙型肝炎病毒的纯化的包膜蛋白用于诊断和治疗目的的单克隆抗体
公开(公告)号：EP1845108A3
公开(公告)日：2007-10-24
申请号：EP07109345.4
申请日：1995-07-31
申请人： Innogenetics N.V.
IPC分类号： C07K16/10 , C12N5/10 , C07K14/18 , A61K39/29 , G01N33/569
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to monoclonal antibodies to purified recombinant HCV envelope proteins. During isolation of the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent; this is followed by a step preventing reformation of disulphide bridges. The present invention also relates to the diagnostic and therapeutic application of these monoclonal antibodies.
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10.发明授权PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE 失效CLEAN丙型肝炎病毒包膜蛋白用于诊断和治疗用途
公开(公告)号：EP0721505B1
公开(公告)日：2002-05-08
申请号：EP95930434.6
申请日：1995-07-31
申请人： INNOGENETICS N.V.
IPC分类号： C12N15/40 , C07K14/18 , C07K16/10 , C12Q1/70 , G01N33/569
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
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