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公开(公告)号：EP1640025B1
公开(公告)日：2010-12-15
申请号：EP04746481.3
申请日：2004-06-25
IPC分类号： A61L31/00
CPC分类号： A61Q19/02 , A61K8/676 , A61K8/99 , A61K31/704 , A61K2800/522 , A61K2800/70 , A61K2800/75 , A61K2800/782 , A61Q19/00 , Y10S435/913 , Y10S435/914 , Y10S435/918
摘要： It is intended to provide a skin composition for external use that contains an ascorbic acid derivative having a high stability, being continuously usable in vivo, having a strong antioxidant effect and showing little skin irritation and has an excellent skin permeability. A composition for external use characterized by containing 2-O-(β-D-glucopyranosyl)ascorbic acid represented by the formula (I) or its salt or ester being safe to the human body together with optionally treated koji mold cells.
摘要翻译： 一种外用组合物，其包含由式（I）表示的2-O-（2-D-吡喃葡萄糖基）抗坏血酸：或其对人体安全的盐或酯，以及曲霉或加工曲 。 外用组合物的皮肤透过性优异，含有稳定性优异，抗生素活性强，抗氧化活性强的抗坏血酸衍生物。
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2.发明授权Process for preparing gamma-hexalactone, products produced therefrom and organoleptic uses of said products 有权一种制备伽马己内酯工艺，制造的产品从中及其作为香料使用
公开(公告)号：EP1038971B1
公开(公告)日：2005-06-15
申请号：EP00302409.8
申请日：2000-03-24
发明人： Farbood, Mohamad I , He, Fenjin , Kizer, Laura E.
IPC分类号： C12P17/04 , C07D307/33 , A23L1/23 , A61K7/46
CPC分类号： C11D3/2096 , A23L27/2024 , A23L27/2026 , A23L27/2052 , A23L27/24 , C11D3/50 , C12P17/04 , Y10S435/911 , Y10S435/913 , Y10S435/918
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公开(公告)号：EP0945518B1
公开(公告)日：2003-05-07
申请号：EP97909738.3
申请日：1997-11-04
发明人： SATO, Eiji, Corp Res. Lab., Mitsubishi Rayon , ENOMOTO, Kanehiko, Corp Res. Lab, Mitsubishi Rayon
CPC分类号： C12P17/182 , C12P41/004 , Y10S435/913 , Y10S435/917 , Y10S435/918 , Y10S435/921 , Y10S435/939
摘要： A process for producing optically active quinuclidinol derivatives characterized by treating racemic 3-quinuclidinol esters represented by general formula (I) (wherein R represents linear or branched alkyl; and (H ) means an optional formation of a salt with a mineral or organic acid) with cells of microorganisms belonging to the genus Aspergillus, Rhizopus, Candida or Pseudomonas and capable of asymmetrically hydrolyzing the ester bond, liquid cultures of the microbial cells, treated microbial cells, enzymes produced by these microorganisms, or enzymes of swine or bovine origin. This process makes it possible to easily produce optically active 3-quinuclidinol derivatives which are valuable intermediates in synthesizing drugs, etc.
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公开(公告)号：EP0266177A3
公开(公告)日：1989-01-25
申请号：EP87309496.5
申请日：1987-10-27
发明人： Kan, Tatsuhiko , Kobayashi, Yoichi
CPC分类号： C12P19/14 , Y10S435/911 , Y10S435/913 , Y10S435/918
摘要： The present invention provides a method of producing oligosaccharides by the reaction between lactose and β-galactosidase from Aspergillus oryzae in which an concentration of lactose in an enzyme reaction mixture is between 50 and 90% (w/v) and a reaction temperature is within the range of 55°C to the temperature at which the β-galactosidase in the reaction mixture is inactivated. This invention therefore makes it possible to obtain the sugar mixture containing high-purity oligosaccharides, small amounts of unreacted lactose and by produced monosaccharides.
摘要翻译： 本发明提供了一种通过来自米曲霉的乳糖和β-半乳糖苷酶之间的反应生产寡糖的方法，其中酶反应混合物中乳糖的浓度为50-90％（w / v），反应温度在 从55℃到反应混合物中β-半乳糖苷酶失活的温度。 因此，本发明可以获得含有高纯度寡糖，少量未反应的乳糖和产生的单糖的糖混合物。
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公开(公告)号：EP0266177A2
公开(公告)日：1988-05-04
申请号：EP87309496.5
申请日：1987-10-27
发明人： Kan, Tatsuhiko , Kobayashi, Yoichi
CPC分类号： C12P19/14 , Y10S435/911 , Y10S435/913 , Y10S435/918
摘要： The present invention provides a method of producing oligosaccharides by the reaction between lactose and β-galactosidase from Aspergillus oryzae in which an concentration of lactose in an enzyme reaction mixture is between 50 and 90% (w/v) and a reaction temperature is within the range of 55°C to the temperature at which the β-galactosidase in the reaction mixture is inactivated. This invention therefore makes it possible to obtain the sugar mixture containing high-purity oligosaccharides, small amounts of unreacted lactose and by produced monosaccharides.
摘要翻译： 本发明提供了通过乳糖和β-半乳糖苷酶与米曲霉之间的反应制备寡糖的方法，其中酶反应混合物中的乳糖浓度为50-90％（w / v），反应温度在 范围为55℃至反应混合物中β-半乳糖苷酶失活的温度。 因此，本发明使得可以获得含有高纯度寡糖，少量未反应的乳糖和产生的单糖的糖混合物。
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公开(公告)号：EP0611826B1
公开(公告)日：2003-05-02
申请号：EP94102235.2
申请日：1994-02-14
IPC分类号： C12P41/00 , C12P17/02 , C07D303/00
CPC分类号： C07D303/08 , C12P17/02 , C12P41/00 , Y10S435/823 , Y10S435/832 , Y10S435/834 , Y10S435/839 , Y10S435/849 , Y10S435/875 , Y10S435/877 , Y10S435/881 , Y10S435/917 , Y10S435/918 , Y10S435/92
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7.发明公开PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-QUINUCLIDINOL DERIVATIVES 失效VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER 3-QUINUCLIDINOL DERIVATE
公开(公告)号：EP0945518A4
公开(公告)日：1999-11-17
申请号：EP97909738
申请日：1997-11-04
申请人： MITSUBISHI RAYON CO
发明人： SATO EIJI , ENOMOTO KANEHIKO
CPC分类号： C12P17/182 , C12P41/004 , Y10S435/913 , Y10S435/917 , Y10S435/918 , Y10S435/921 , Y10S435/939
摘要： A process for producing optically active quinuclidinol derivatives characterized by treating racemic 3-quinuclidinol esters represented by general formula (I) (wherein R represents linear or branched alkyl; and (H ) means an optional formation of a salt with a mineral or organic acid) with cells of microorganisms belonging to the genus Aspergillus, Rhizopus, Candida or Pseudomonas and capable of asymmetrically hydrolyzing the ester bond, liquid cultures of the microbial cells, treated microbial cells, enzymes produced by these microorganisms, or enzymes of swine or bovine origin. This process makes it possible to easily produce optically active 3-quinuclidinol derivatives which are valuable intermediates in synthesizing drugs, etc.
摘要翻译： 一种制备光学活性的奎宁醇衍生物的方法，其特征在于处理由通式（I）表示的外消旋3-奎核醇醇酯（其中R代表直链或支链烷基;和（H +）意指任意形成与矿物或 有机酸）与属于曲霉属，根霉属，假丝酵母属或假单胞菌属的微生物的细胞并且能够不对称地水解酯键，微生物细胞的液体培养物，经处理的微生物细胞，由这些微生物产生的酶或猪或牛的酶 起源。 该过程使得可以容易地制备光学活性的3-奎宁环醇衍生物，其是合成药物等中有价值的中间体。
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8.发明公开A process for improving the property of proanthocyanidins and for preparing an improved proanthocyanidin product 失效一种用于改善原花青素的属性，并用于产生一种改进的Proanthocyanidinproduktes过程
公开(公告)号：EP0727493A3
公开(公告)日：1997-09-17
申请号：EP96101987.4
申请日：1996-02-12
申请人： KIKKOMAN CORPORATION
IPC分类号： C12P17/06
CPC分类号： C12P17/06 , Y10S435/918
摘要： The present invention is directed to a process for improving the property of proanthocyanidins comprising contacting the proanthocyanidin containing solution with tannase and a process for increasing the yield of proanthocyanidins comprising contacting the proanthocyanidin containing solution with tannase in the extraction of the proanthocyanidins.
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公开(公告)号：EP0611826A3
公开(公告)日：1995-07-26
申请号：EP94102235.2
申请日：1994-02-14
IPC分类号： C12P41/00 , C12P17/02 , C07D303/00
CPC分类号： C07D303/08 , C12P17/02 , C12P41/00 , Y10S435/823 , Y10S435/832 , Y10S435/834 , Y10S435/839 , Y10S435/849 , Y10S435/875 , Y10S435/877 , Y10S435/881 , Y10S435/917 , Y10S435/918 , Y10S435/92
摘要： A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida , the genus Rhodosporidium , the genu s Rhodococcus and the genus Nosardioides . Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon , the genus Geotrichum , the genus Corynebacterium , the genus Micrococcus and the genus Brevibacterium . The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.
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公开(公告)号：EP0390624A1
公开(公告)日：1990-10-03
申请号：EP90400518.8
申请日：1990-02-26
申请人： ELF SANOFI
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , Y10S435/917 , Y10S435/918 , Y10S435/933 , Y10S435/945
摘要： L'invention a pour objet un procédé d'obtention de méthylcétones en C₅ à C₁₀ par bioconversion d'acides gras en C₆ à C₁₁ par des spores de champignons filamenteux du genre Amastigomycota . Ce procédé est mis en oeuvre dans un solvant organique inerte dont le logarithme du coefficient de partage entre l'eau et l'octane est supérieur à 4, avantageusement dans un hydrocarbure aliphatique en C₈ à C₂₀ ou un mélange de tels hydrocarbures, contenant au plus 20% d'eau. Application : obtention de méthylcétones arômatiques comme aromes.
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