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公开(公告)号：EP3984551A1
公开(公告)日：2022-04-20
申请号：EP21186416.0
申请日：2012-11-30
发明人： KURTIS, Jonathan , NIXON, Christian Parcher , RAJ, Dipar Kumar , FRIEDMAN, Jennifer Frances , FRIED, Michal , DUFFY, Patrick Emmet
IPC分类号： A61K39/015
摘要： The invention provides compositions and methods for preventing or reducing the severity of malaria.
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公开(公告)号：EP3893925A1
公开(公告)日：2021-10-20
申请号：EP19897172.3
申请日：2019-12-13
发明人： WANDS, Jack, R. , DONG, Xiaoqun
IPC分类号： A61K39/00 , A61K35/17 , C12N9/06 , C07K7/00 , C07K14/435
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公开(公告)号：EP3220914B1
公开(公告)日：2020-09-02
申请号：EP15861300.0
申请日：2015-11-17
发明人： CHEN, Qian , YU, Hongchuan , CHEN, Yupeng
IPC分类号： A61K31/535 , A61L27/22 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/54 , C07D471/04 , C07D487/04 , C07D519/00 , A61K47/54 , A61K47/69 , A61F2/30 , A61K45/06
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4.发明授权
公开(公告)号：EP3234681B1
公开(公告)日：2020-02-26
申请号：EP15871100.2
申请日：2015-12-17
IPC分类号： G02B21/00 , G01N21/64 , G02B21/16 , G02B21/36 , G01N33/569
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公开(公告)号：EP3481445A1
公开(公告)日：2019-05-15
申请号：EP17742589.9
申请日：2017-07-06
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公开(公告)号：EP3393383A1
公开(公告)日：2018-10-31
申请号：EP16880144.7
申请日：2016-12-23
CPC分类号： A61B18/14 , A61B18/1815 , A61B2018/00095 , A61B2018/00577 , A61B2018/00982
摘要： A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a low-viscosity but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.
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公开(公告)号：EP3166600A4
公开(公告)日：2018-07-04
申请号：EP15818987
申请日：2015-07-10
发明人： DUDLEY SAMUEL
IPC分类号： A61K31/16 , A61K31/221 , A61K31/66 , A61K31/665 , A61K31/675 , A61K31/7084 , A61K38/06 , A61K38/07 , A61L29/16 , A61L31/16 , A61P9/06
CPC分类号： A61K31/675 , A61K31/221 , A61K31/66 , A61K31/665 , A61K31/7084 , A61K38/063 , A61K38/07 , A61L29/16 , A61L31/16 , A61L2300/40 , A61P9/06 , A61K2300/00
摘要： This invention relates to reducing the risk of arrhythmias as a result of an acute cardiovascular disorder or injury such as a myocardial infarction by using mitochondrial-targeted antioxidants to improve cardiac function.
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公开(公告)号：EP3116392A4
公开(公告)日：2018-02-14
申请号：EP15762394
申请日：2015-03-16
发明人： CHEN QIAN , CHEN YUPENG , YU HONGCHUAN , EHRLICH MICHAEL G
IPC分类号： A61K47/69 , A61K9/51 , C12N15/113
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0092 , A61K9/08 , A61K9/5123 , A61K9/5146 , A61K47/6949 , A61K49/0095 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32 , C12Q1/6881 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , C12Y304/24812 , G01N33/6893 , G01N2800/102
摘要： The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
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公开(公告)号：EP2897607A4
公开(公告)日：2016-10-05
申请号：EP13838498
申请日：2013-09-20
IPC分类号： A61K31/341 , A61P35/00 , C07D307/32 , C07D307/66 , C07D405/12 , C07D409/04 , C07D417/04
CPC分类号： C07D417/04 , C07D307/32 , C07D307/66 , C07D405/04 , C07D405/12 , C07D409/04 , C12Q1/26
摘要： The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
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公开(公告)号：EP2061442B1
公开(公告)日：2016-08-31
申请号：EP07837956.7
申请日：2007-09-10
IPC分类号： A61K31/00 , A61K51/00 , A61K31/425 , A61P25/32 , A61P43/00
CPC分类号： A61K31/425 , A61K31/47
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