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1.发明公开BLENDS OF QUINONE ALKIDE AND NITROXYL COMPOUNDS AS POLYMERIZATION INHIBITORS 审中-公开QUINONALKIDE和用作聚合抑制剂MIXTURES硝酰基
公开(公告)号：EP1332196A1
公开(公告)日：2003-08-06
申请号：EP01981357.5
申请日：2001-10-02
发明人： BENAGE, Brigitte
IPC分类号： C09K15/30 , C09K15/08 , C07C51/50 , C07C7/20 , C07C15/46 , C07C67/62 , C07C50/00 , C07B63/04 , G03F7/027 , C08F2/38
CPC分类号： C09K15/30 , C07B63/04 , C07C7/20 , C07C17/42 , C07C59/82 , C07C67/62 , C08F4/40 , C09K15/08 , G03F7/027 , C07C21/21 , C07C69/54
摘要： Disclosed herein is a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position. Additionally, a composition is disclosed that comprises: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position.
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2.发明公开NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION CONTAINING THE NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, USES AND THERAPEUTIC METHOD 审中-公开用于生产PTEROCARPANCHINONFAMILIE药物组合物，应用和治疗方法的新化合物PTEROCARPANCHINONFAMILIE，工艺的新化合物
公开(公告)号：EP2366684A4
公开(公告)日：2012-07-25
申请号：EP09825667
申请日：2009-11-05
申请人： UNIV RIO DE JANEIRO
发明人： DA SILVA ALCIDES JOSE MONTEIRO , RUMJANEK VIVIAN MARY BARRAL DOLD , BERGMANN BARTIRA ROSSI , DOS SANTOS EDUARDO SALUSTIANO JESUS , COSTA PAULO ROBERTO RIBEIRO , NETTO CHAQUIP DAHER , LIMA WALLACE PACIENZA , DOS SANTOS EDUARDO CAIO TORRES , CAVALCANTE MOISES CLEMENTE MARINHO , SEABRA SERGIO HENRIQUE , RICA SERGIO HENRIQUE
IPC分类号： C07C50/22 , A61K31/00 , A61K31/122 , A61P33/00 , A61P35/00 , C07C46/00 , C07C50/00 , C07D493/04
CPC分类号： C07D493/04 , C07B2200/07
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3.发明公开
公开(公告)号：EP4048246A1
公开(公告)日：2022-08-31
申请号：EP20880080.5
申请日：2020-10-26
IPC分类号： A61K31/12 , A61K31/122 , A61K31/662 , C07C50/00 , C07C50/26 , C07C50/32
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公开(公告)号：EP0350709B1
公开(公告)日：1994-09-21
申请号：EP89111686.5
申请日：1989-06-27
IPC分类号： H01B1/12 , C07C50/00 , C07C221/00 , G02F1/35
CPC分类号： H01B1/121 , C07C50/16 , C07C50/24 , C07C50/34 , C07C225/34 , C07C255/31 , C07C255/47 , Y10S505/811
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公开(公告)号：EP2477957A1
公开(公告)日：2012-07-25
申请号：EP10817759.3
申请日：2010-09-15
申请人： HY Biopharma Inc.
摘要： The present invention provides a method for making hypericin comprising the steps of converting a protohypericin to a protohypericin salt, and irradiating the protohypericin salt with visible light to form hypericin. The present invention also provides an apparatus comprising a transparent column having a top end and a bottom end, an inlet attached to the column at the top end to flow reactants into the column, a container attached to the column at the bottom end; and a visible light source positioned to cast light on to the column. The present invention further provides a method for making hypericin using said apparatus.
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6.发明公开NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION CONTAINING THE NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, USES AND THERAPEUTIC METHOD 审中-公开用于生产PTEROCARPANCHINONFAMILIE药物组合物，应用和治疗方法的新化合物PTEROCARPANCHINONFAMILIE，工艺的新化合物
公开(公告)号：EP2366684A1
公开(公告)日：2011-09-21
申请号：EP09825667.0
申请日：2009-11-05
发明人： DA SILVA, Alcides José Monteiro , RUMJANEK, Vivian Mary Barral Dold , BERGMANN, Bartira Rossi , DOS SANTOS, Eduardo Salustiano Jesus , COSTA, Paulo Roberto, Ribeiro , NETTO, Chaquip Daher , LIMA, Wallace, Pacienza , DOS SANTOS, Eduardo Caio Torres , CAVALCANTE, Moisés Clemente, Marinho , SEABRA, Sérgio, Henrique , RICA, Sérgio Henrique
CPC分类号： C07D493/04 , C07B2200/07
摘要： This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-α in human and nonhuman mammals.
摘要翻译： 本发明属于化学制药领域。 在式（I）gemäß呈现给本发明pterocarpanquinone家族的新化合物能够通过还原烷基化生成细胞内物质被激活。 它提出对哺乳动物特别是人类和非人类细胞的选择性细胞毒性效应并不断分裂，可用于治疗与不期望的细胞增殖的现象的疾病和功能障碍有用。 搜索化合物因此为与在人和非人哺乳动物高水平TNF±的疾病或功能障碍治疗有效。
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7.发明授权UTILISATION DE DERIVES TRICYCLIQUES DU 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTALENE, NOUVEAUX COMPOSES OBTENUS ET LEUR APPLICATION EN THERAPEUTIQUE 失效三环1,4-二氢-1,4-二氧代-1H-NAPHALEN衍生物的用途，新化合物和治疗用途
公开(公告)号：EP0876356B1
公开(公告)日：2001-10-31
申请号：EP96941734.4
申请日：1996-12-10
发明人： BOUTHERIN-FALSON, Odile , DESQUAND-BILLIALD, Stéphanie , FAVROU, Anita , FINET, Michel , TEMBO, Olivier , TORREGROSA, Jean-Luc , YANNIC-ARNOULT Sylvie , DOMAGALA-LE MARQUER, Florence
IPC分类号： C07D235/02 , C07D263/60 , C07D413/04 , C07D277/84 , C07D417/04 , A61K31/41 , C07C50/00 , C07C225/28
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/423 , A61K31/428 , C07C46/00 , C07C50/24 , C07C50/32 , C07C225/30 , C07C2602/12 , C07D263/60 , C07D277/84 , C07D417/04
摘要： The therapeutical use of tricyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), for treating diseases related to venous function deficiency and/or inflammatory oedema, is disclosed. In general formula (I), A is a sulphur or oxygen atom or a radical R3N where R3 is a hydrogen atom, a C1-5 alkyl radical or an optionally substituted aromatic or heteroaromatic ring; R1 is either a C1-5 alkyl radical, or a radical R4NH where R4 is a hydrogen atom, a C1-5 alkyl radical or an optionally substituted aromatic or heteroaromatic ring, or an aromatic ring optionally substituted by one or more acceptor or donor groupings, or a heteroaromatic ring having one or more heteroatoms and being optionally substituted by acceptor or donor groupings; and R2 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, an oxygen atom optionally substituted by a C1-5 alkyl radical, or a radical NR5R5', where each of R5 and R5' is independently a hydrogen or oxygen atom or C1-5 monovalent organic radicals.
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公开(公告)号：EP2601168A1
公开(公告)日：2013-06-12
申请号：EP11815337.8
申请日：2011-08-04
IPC分类号： C07C50/00
CPC分类号： A61K31/122
摘要： Methods of treating, preventing or suppressing symptoms associated with mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), dominant optic atrophy (DOA); mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Leigh syndrome or Kearns-Sayre Syndrome (KSS) with vitamin K are disclosed.
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公开(公告)号：EP0350709A3
公开(公告)日：1990-08-22
申请号：EP89111686
申请日：1989-06-27
IPC分类号： C07C50/16 , C07C50/24 , C07C50/34 , C07C225/34 , C07C255/31 , C07C255/47 , G02F1/35 , G02F1/355 , G02F1/361 , H01B1/12 , C07C50/00 , C07C97/00
CPC分类号： H01B1/121 , C07C50/16 , C07C50/24 , C07C50/34 , C07C225/34 , C07C255/31 , C07C255/47 , Y10S505/811
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