公开(公告)号：EP2067782B2

公开(公告)日：2018-06-27

申请号：EP07806161.1

申请日：2007-08-28

Applicant: Tosoh Corporation

Inventor： WATANABE, Makoto

IPC: C07D495/04 ,  C07B61/00 ,  C07C17/263 ,  C07C25/18 ,  C07C25/22 ,  C07D333/62 ,  C07D495/22 ,  C07F5/02 ,  C07F9/6568 ,  H01L51/05 ,  H01L51/30

CPC classification number: C07F9/65683 ,  C07C17/12 ,  C07C17/263 ,  C07C17/2632 ,  C07C17/35 ,  C07C17/361 ,  C07C25/22 ,  C07C46/00 ,  C07D333/62 ,  C07D495/04 ,  C07D495/14 ,  C07D495/22 ,  C07D517/04 ,  C07F5/027 ,  H01L51/0074 ,  C07C25/02 ,  C07C25/18 ,  C07C50/24

Abstract: There are provided a heteroacene derivative having an excellent oxidation resistance and capable of forming a semiconductor active phase by a coating process, and an oxidation-resistant organic semiconductor material using the same, as well as an organic thin film. [Means for Resolution] heteroacene derivative represented by the formula (1) is obtained by tetrametalation of a tetrahaloterphenyl derivative with a metalation agent and subsequent treatment of the resulting compound with reaction agents: wherein the substituents R 1 to R 4 are the same or different and each represents a hydrogen atom, a fluorine atom, a chlorine atom, an aryl group having 4 to 30 carbon atoms, an alkyl group having 3 to 20 carbon atoms, or a halogenated alkyl group having 1 to 20 carbon atoms; T 1 and T 2 are the same or different and each represents sulfur, selenium, tellurium, oxygen, phosphorus, boron, or aluminum; 1 and m each is an integer of 0 or 1; and rings A and B are the same or different and each has a structure represented by the following formulae (A-1) or (A-2).

公开(公告)号：EP2250145A4

公开(公告)日：2012-02-22

申请号：EP09726449

申请日：2009-03-06

Applicant: ALKEM LAB LTD

Inventor： SANJAY SUKUMAR SARALAYA ,  SHASHIKUMAR HIRIYALU SOMASHEKAR ,  SHASHIPRABHA ,  SHRIDHARA KANAKAMAJALU ,  KOOTTUNGALMADHOM RAMASWAMY RANGANATHAN ,  VEERSWAMY ANANTHALAKSHMI ,  GOVINDARAJALU JEYARAMAN ,  KOTHAPALLI SUNDARRAJA RAO ,  KUPPUSWAMY NAGARAJAN

IPC: C07C46/00 ,  C07C46/10 ,  C07C50/24 ,  C07C50/32

CPC classification number: C07C46/00 ,  C07C46/10 ,  C07C50/32 ,  C07C2601/14 ,  C07C2602/10 ,  C07C50/24

公开(公告)号：EP1379703B1

公开(公告)日：2006-02-08

申请号：EP02711685.4

申请日：2002-01-24

Applicant: HYDRO-QUEBEC

Inventor： MAHDAVI, Behzad ,  HARRISON, Stephen ,  AMOUZEGAR, Kamyab

IPC: C22B3/22 ,  C22B3/44 ,  C25B3/02 ,  C25B15/08 ,  C07C45/28

CPC classification number: C22B3/20 ,  C07C45/36 ,  C07C46/02 ,  C07C46/04 ,  Y02P10/234 ,  C07C47/542 ,  C07C50/24 ,  C07C50/12

Abstract: A method for purifying a Redox mediator, e.g. solutions of Ce III/Ce IV or Cr III/Cr VI, used in a chemical process of oxidation of organic compounds. The desired purification is obtained by recovering the mediator in the form of a solution and heating this solution to evaporate the volatile impurities contained in it and to oxidize the non volatile impurities into compounds which precipitate and are extracted by filtration. The purification takes place before the mediator is regenerated in the electrolysis cell. This prevents the impurities contained in the mediator solution to negatively affect the operation of this cell.

公开(公告)号：EP1242363B1

公开(公告)日：2005-11-02

申请号：EP00985603.0

申请日：2000-12-18

Applicant: AstraZeneca AB

Inventor： CHAPDELAINE, Marc, Jerome ,  KNAPPENBERGER, Katherine ,  STEELMAN, Gary ,  SUCHARD, Suzanne ,  SYGOWSKI, Linda ,  URBANEK, Rebecca ,  VEALE, Chris, Allan

IPC: C07C233/76 ,  C07C233/33 ,  C07D307/80 ,  C07D333/22 ,  A61K31/165 ,  A61K31/34 ,  A61K31/38 ,  A61P37/06

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07C50/16 ,  C07C50/20 ,  C07C50/24 ,  C07C50/34 ,  C07C50/38 ,  C07C205/46 ,  C07C225/32 ,  C07C233/33 ,  C07C233/76 ,  C07C235/38 ,  C07C235/74 ,  C07C235/84 ,  C07C311/21 ,  C07C311/48 ,  C07C2603/26 ,  C07D307/80 ,  C07D317/26 ,  C07D333/22 ,  C07K5/06026 ,  C07K5/06104 ,  C07K5/1021

Abstract: Substituted phenantheren-9, 10-diones in accord with structural diagram (I), compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH¿2?, NO2, NH-CO-R?2¿, CO-NH-R2, Ar, (CH¿2?)nCH(COOH)R?3 COR3¿ and NHCOCH¿2?CH(COOH)NHR?4¿, where R?2, R3 and R4¿ are a selected from a variety of substituted or unsubstituted alkyl and aryl groups and oligopeptides.

Abstract translation: 根据结构图I，其组合物及其使用方法，用于治疗T细胞介导的病症如自身免疫性疾病和器官移植物排斥，取代菲-9,10-二酮。 在本发明的化合物中，R 1在每次出现时独立地选自氢，卤素，NH-甲苯磺酰基，N-二 - 甲苯磺酰基，NH 2，NO 2，NH-CO-R 2，CO-NH- 2，Ar，（CH 2）n CH（COOH）R 3 COR 3和NHCOCH 2 CH（COOH）NHR 4，其中R 2，R 3和R 4选自 各种取代或未取代的烷基和芳基基团寡肽。

公开(公告)号：EP1259231B1

公开(公告)日：2005-05-25

申请号：EP00985618.8

申请日：2000-12-18

Applicant: AstraZeneca AB

Inventor： CHAPDELAINE, Marc, Jerome ,  KNAPPENBERGER, Katherine ,  STEELMAN, Gary ,  SUCHARD, Suzanne ,  SYGOWSKI, Linda ,  URBANEK, Rebecca ,  VEALE, Chris, Allan

IPC: A61K31/122

CPC classification number: C07C205/46 ,  A61K31/122 ,  A61K31/235 ,  C07C46/00 ,  C07C50/24 ,  C07C69/95 ,  C07C50/38 ,  C07C50/10 ,  C07C50/14

Abstract: Substituted naphthalenediones in accord with structural diagram (I): compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, wherein: Q1 at each occurrence is independently selected from hydrogen, hydroxy, halogen, C(O)O(C¿1?-C3) alkyl and C(O)phenyl, and Q?2¿ is selected from hydrogen, halogen, O-(C¿1?-C3)alkyl, O-(C1-C3)alkenyl, phenyl, indolyl and naphthyl, where phenyl may be mono- or di-substituted with NO2 or halogen, and indolyl may be substituted with (C1-C3)alkyl or phenyl.

公开(公告)号：EP1242363A2

公开(公告)日：2002-09-25

申请号：EP00985603.0

申请日：2000-12-18

Applicant: AstraZeneca AB

Inventor： CHAPDELAINE, Marc, Jerome ,  KNAPPENBERGER, Katherine ,  STEELMAN, Gary ,  SUCHARD, Suzanne ,  SYGOWSKI, Linda ,  URBANEK, Rebecca ,  VEALE, Chris, Allan

IPC: C07C233/76 ,  C07C233/33 ,  C07D307/80 ,  C07D333/22 ,  A61K31/165 ,  A61K31/34 ,  A61K31/38 ,  A61P37/06

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07C50/16 ,  C07C50/20 ,  C07C50/24 ,  C07C50/34 ,  C07C50/38 ,  C07C205/46 ,  C07C225/32 ,  C07C233/33 ,  C07C233/76 ,  C07C235/38 ,  C07C235/74 ,  C07C235/84 ,  C07C311/21 ,  C07C311/48 ,  C07C2603/26 ,  C07D307/80 ,  C07D317/26 ,  C07D333/22 ,  C07K5/06026 ,  C07K5/06104 ,  C07K5/1021

Abstract: Substituted phenantheren-9, 10-diones in accord with structural diagram (I), compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH¿2?, NO2, NH-CO-R?2¿, CO-NH-R2, Ar, (CH¿2?)nCH(COOH)R?3 COR3¿ and NHCOCH¿2?CH(COOH)NHR?4¿, where R?2, R3 and R4¿ are a selected from a variety of substituted or unsubstituted alkyl and aryl groups and oligopeptides.

公开(公告)号：EP0543346A1

公开(公告)日：1993-05-26

申请号：EP92119637.4

申请日：1992-11-17

Applicant: LONZA AG ,  Sankyo Company Limited

Inventor： Laffan, David, Dr.

IPC: C07D311/58 ,  C07C50/24

CPC classification number: C07D311/70 ,  C07C46/08 ,  C07C50/24 ,  C07D311/58

Abstract: Es wird ein neues Verfahren zur Herstellung von Pentaalkylchromenen der allgemeinen Formel

beschrieben. Dabei wird ein Trialkylhydrochinon mit einem halogenierten Butenol zu einem subst. Tetraalkylhydrochinon umgesetzt, dieses oxidiert anschliessend das Halogenatom mit einem geeigneten Nucleophil substituiert und schliesslich zum Endprodukt cyclisiert.
Die Pentaalkylchromene sind geeignete Zwischenprodukte zur Herstellung von lipidsenkenden Pharmazeutika.

Abstract translation: 描述了制备通式“IMAGE”的五烷基色烯的新方法。 在该方法中，使三烷基氢醌与卤化丁烯醇反应，得到一个低级烷基。 四烷基氢醌，这被氧化，然后卤素原子被合适的亲核试剂取代，产物最终环化成最终产物。 五烷基色烯是制备降血脂药物的合适中间体。

公开(公告)号：EP0278377B1

公开(公告)日：1992-04-08

申请号：EP88101533.3

申请日：1988-02-03

Applicant: HOECHST AKTIENGESELLSCHAFT

Inventor： Arndt, Otto, Dr. ,  Papenfuhs, Theodor, Dr.

IPC: C07C50/24 ,  C07C46/06

CPC classification number: C07C46/00 ,  C07C37/62 ,  C07C46/06 ,  C07C50/24 ,  C07C39/245

公开(公告)号：EP0306940B1

公开(公告)日：1992-01-29

申请号：EP88114679.9

申请日：1988-09-08

Applicant: Yokoyama, Kikuko

Inventor： Yokoyama, Yoshio

IPC: C07C50/18 ,  C07C46/00 ,  B01J23/00 ,  B01J31/26

CPC classification number: B01J37/03 ,  B01J21/14 ,  B01J23/745 ,  B01J27/14 ,  B01J27/188 ,  B01J27/24 ,  B01J29/061 ,  B01J31/02 ,  B01J31/0237 ,  B01J31/0244 ,  B01J31/26 ,  B01J37/0009 ,  C07C46/00 ,  C07C50/24 ,  C07C50/16 ,  C07C50/20 ,  C07C50/18

公开(公告)号：EP0430164A2

公开(公告)日：1991-06-05

申请号：EP90122643.1

申请日：1990-11-27

Applicant: NIPPON SHOKUBAI KAGAKU KOGYO CO. LTD.

Inventor： Sugishima, Noboru ,  Ikeda, Noriaki ,  Fujii, Yasushi ,  Aoki, Ryuji ,  Hatta, Yumi

IPC: C07C46/04 ,  C07C46/10 ,  C07C46/00 ,  C07C50/10 ,  C07C50/24 ,  C07C205/46 ,  C07C66/00 ,  C07C50/16

CPC classification number: C07C323/22 ,  C07C46/02 ,  C07C46/04 ,  C07C46/10 ,  C07C49/675 ,  C07C49/697 ,  C07C50/10 ,  C07C50/24 ,  C07C51/353 ,  C07C66/02 ,  C07C201/12 ,  C07C303/32 ,  C07C2602/10 ,  C07C2603/22 ,  C07C2603/24 ,  C07C50/16 ,  C07C205/46 ,  C07C205/47 ,  C07C66/00 ,  C07C309/25

Abstract: A process for preparation of a 2-substituted-1,4-naphthoquinone which comprises oxidizing a 2-substituted naphthalene to obtain reaction products comprising a 2-substituted-1,4-naphthoquinone and a 6-substituted-1,4-naphthoquinone; adding a diene compound to the reaction products and heating the mixture to form a Diels-Alder reaction adduct between the diene compound and the 6-substituted-1,4-naphthoquinone in the reaction products; and separating the 2-substituted-1,4-naphthoquinone from the adduct.