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9 条记录 (耗时 0.009 秒)

    Polycyclic biocidal compounds, their synthesis, formulations containing them
    1.
    发明公开
    Polycyclic biocidal compounds, their synthesis, formulations containing them 失效
    多环生物化合物，其合成，含有它们的制剂

    公开(公告)号：EP0182609A3

    公开(公告)日：1987-11-19

    申请号：EP85308280

    申请日：1985-11-14

    申请人： THE WELLCOME FOUNDATION LIMITED

    发明人： Bair, Kenneth Walter

    IPC分类号： C07C91/23 ,  C07C91/18 ,  A61K31/13 ,  C07C47/546

    CPC分类号： C07C47/546 ,  C07C47/55

    摘要： The invention relates to biocidal compounds of the formula RCH 2 NHR 1 or monomethyl or monoethyl ethers thereof, the compounds including the said ethers containing no more than 30 carbon atoms in total; esters thereof; salts thereof; wherein R = C 15-22 carbocyclic fused ring system containing 3-5 aromatic rings optionally substituted by 1-2 substituents, said substituents (containing ≤ 4 carbon atoms in total) being halogen; cyano; C 1-4 alkyl or C 1-4 alkoxy, each optionally substituted by OH or C 1-2 alkoxy; halogen substituted C 1-2 alkyl or C 1-2 alkoxy; S(O) n R 2 n = 0-2 and R 2 is C 1-2 alkyl optionally substituted by OH or C 1-2 alkoxy; or R is optionally substituted by NR 3 R 4 (which contains ≤ 5 carbons) wherein R 3 and R 4 = C 1 3 alkyl group or NR 3 R 4 forms a 5- or 6- membered heterocyclic ring optionally containing 1-2 additional heteroatoms; R 1 contains ≤ 8 carbons and is
    wherein m is 0 or 1; R 5 and R 6 = H or C 1-5 alkyl optionally substituted by OH; R 7 and R 8 = H, C 1-3 alkyl; -C-C-is a five-or-six-membered saturated carbocyclic ring; R 9 is H, CH 3 or CH 2 OH; R 10 , R 11 and R 12 = H or CH 3 ; R 13 = H, CH 3 , OH or CH 2 0H with the proviso that R is not substituted or unsubstituted perylene, fluoranthene, chrysene, pyrene or triphenylene. Also disclosed are formations containing the compounds, methods for their preparation, chemical intermediates in their preparation and the use of the compounds in the treatment of tumors and as antipathogenic agents particularly antifungal agents.

    Aminohydroxyalkylbenzene anti-obesity and/or anti-hyperglycaemic agents
    3.
    发明公开
    Aminohydroxyalkylbenzene anti-obesity and/or anti-hyperglycaemic agents 失效
    氨基甲基苯乙酮抗体和/或抗高血压药物

    公开(公告)号：EP0196849A3

    公开(公告)日：1988-01-07

    申请号：EP86302145

    申请日：1986-03-24

    申请人： BEECHAM GROUP PLC

    发明人： Smith, David Glynn ,  White, Susan Mary

    IPC分类号： C07C91/18 ,  C07C93/06 ,  C07C91/34 ,  C07C91/40 ,  A61K31/135 ,  C07C87/18 ,  C07C93/08

    CPC分类号： A61K31/135 ,  A23K20/111 ,  A61K31/165

    摘要： A compound of formula (I):
    or a pharmaceutically acceptable salt thereof, wherein R A is a group of formula (a):
    wherein T represents a group of formula (b):
    wherein Q is
    , and where
    R' is a hydrogen or halogen atom or a -CF 3 , OR 4 , NHR 4 , -NHCOR 4 , -NHCONH 2 , NHSO 2 R 4 , CH 2 OR 4 or -CH 2 SO 2 R 4 group: R 2 is a hydrogen or halogen atom or an -OR 4 group; R 3 is a hydrogen or halogen atome; and R 4 is hydrogen, C 1-6 alkyl or benzyl; X' is a bond or -OCH 2 -; X 2 is a group of formula -CR 5 R 6 -CH 2 -A-wherein R 5 and R 6 are independently hydrogen or methyl; and A is a bond, -CH 2 -, or O; T' represents a hydrogen atom or a group of formula (b) as defined above in respect of T, such that T' and T may be the same or different; R C represents a group (a) as defined above in respect of R A , such that R C and R A may be the same or different; provided that when R A and R C each represent a group of formula:
    wherein R is oH or -O-benzyl; then when A is a bond, -CH 2 - or -0, R' is not -CH 2 OH or NHSO 2 -C 1-4 alkyl; processes for the preparation of such compounds and their use in medicine and agriculture.

    Method for promoting growth and reducing fat in animals using phenylethanolamine derivatives
    9.
    发明公开
    Method for promoting growth and reducing fat in animals using phenylethanolamine derivatives 失效
    促进生长和通过bzw-Phenyläthanolamin衍生物减少在动物脂肪的方法。

    公开(公告)号：EP0026298A1

    公开(公告)日：1981-04-08

    申请号：EP80104619.4

    申请日：1980-08-06

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Kiernan, Jane Ann ,  Baker, Pamela Koenig

    IPC分类号： A23K1/16 ,  C07C91/18 ,  C07C91/40 ,  C07C93/14

    CPC分类号： A23K20/111

    摘要： A method for the preparation of an animal feed composition comprising admixing an animal feed with from 0.01 to 400 grams per ton of feed of a compound of the following formula
    wherein X, Y, Z, R,, R2, R 3 and R 4 are as defined in the text.
    Some new compounds with the same general formula are claimed. These phenylethanol amine derivatives and their acid addition salts act as growth promotors and fat reducing agents in farm and companion animals.

    摘要翻译： 一种用于动物饲料组合物的方法，包括将与动物饲料的制备方法从每吨下式的化合物的进料的0点01克至400克： worin X，Y，Z，R1，R2，R3和R4 如在文本中定义。 具有相同的通式的一些新化合物已声明。 这些苯胺衍生物及其酸加成盐作为促生长剂和在农场和伴侣动物脂肪的还原剂。