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公开(公告)号：EP4013742A1
公开(公告)日：2022-06-22
申请号：EP20852190.6
申请日：2020-07-21
申请人： Merck Sharp & Dohme Corp. , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John A. , COWMAN, Alan F. , DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , OLSEN, David B. , SLEEBS, Brad , THOMPSON, Jennifer K. , TRIGLIA, Tony , ZHAN, Dongmei , ZHANG, Cailing , ZHAO, Lianyun
IPC分类号： C07D239/22 , C07D405/04 , C07D405/14 , A61K31/513 , A61P33/06
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公开(公告)号：EP3116862B1
公开(公告)日：2019-04-17
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D513/08 , A61K31/554 , A61P31/18
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公开(公告)号：EP3116862A1
公开(公告)日：2017-01-18
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D281/10 , C07D241/36
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。
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4.发明公开
公开(公告)号：EP3027593A2
公开(公告)日：2016-06-08
申请号：EP14832049.2
申请日：2014-07-29
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BENNETT, David J. , BUNGARD, Christopher J. , CHANG, Lehua , CHU, Xin-Jie , DWYER, Michael P. , HOLLOWAY, M. Katherine , KEERTIKAR, Kartik M. , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , MORRIELLO, Gregori J. , SHEN, Dong-Ming , SHERER, Edward C. , SCHULZ, Jurgen , WADDELL, Sherman Tim , WISCOUNT, Catherine M. , ZORN, Nicolas , SATYANARAYANA, Tummanapalli , VIJAYASARADHI, Sivalenka , HU, Bin , JI, Tao , ZHONG, Bin
IPC分类号： C07D295/088
CPC分类号： C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶中的用途，HIV复制的抑制，HIV预防感染，HIV感染治疗以及预防，治疗 ，并延迟艾滋病的发病或进展。
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公开(公告)号：EP4444722A1
公开(公告)日：2024-10-16
申请号：EP22850760.4
申请日：2022-12-05
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John, A. , DE LERA RUIZ, Manuel , GUO, Zhuyan , NANTERMET, Philippe , KELLY III, Michael, J. , GUTIERREZ BONET, Alvaro , ZHAO, Lianyun , LEI, Zhiyu , HU, Bin , ZHAN, Dongmei , HODDER, Anthony
IPC分类号： C07D491/16 , C07D491/18 , C07D491/22 , A61K31/519 , A61P33/06
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公开(公告)号：EP4100401A1
公开(公告)日：2022-12-14
申请号：EP21751452.0
申请日：2021-02-02
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , MCCAULEY, John A. , OLSEN, David B. , SLEEBS, Brad , TRIGLIA, Tony , ZHAN, Dongmei , ZHAO, Lianyun
IPC分类号： C07D401/10 , C07D403/10 , C07D417/10 , C07D471/04 , A61K31/513 , A61P33/06
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公开(公告)号：EP4061375A1
公开(公告)日：2022-09-28
申请号：EP20891004.2
申请日：2020-11-16
申请人： Merck Sharp & Dohme LLC , MSD R&D (China) Co., Ltd. , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： MCCAULEY, John, A. , DE LERA RUIZ, Manuel , GUO, Zhuyan , HU, Bin , KELLY III, Michael, J. , LEI, Zhiyu , OLSEN, David, B. , SLEEBS, Brad , ZHAN, Dongmei , ZHAO, Lianyun
IPC分类号： A61K31/5377 , A61K31/541 , C07D215/52
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公开(公告)号：EP3177614A1
公开(公告)日：2017-06-14
申请号：EP15829695.4
申请日：2015-08-05
IPC分类号： C07D409/12 , C07D493/04 , C07D215/16 , C07D215/20 , C07D413/00 , C07D307/80 , A61K31/192 , A61K31/44 , A61K31/47 , A61K31/343 , A61K31/34
CPC分类号： C07D405/14 , A61K31/335 , A61K31/397 , A61K31/4427 , A61K31/444 , A61K45/06 , C07D313/08 , C07D405/04 , C07D405/10 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译： 结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，并且可用于治疗，预防和抑制由G蛋白偶联介导的疾病 受体40.本发明化合物可用于治疗2型糖尿病以及通常与该疾病相关的病症，包括肥胖和脂质紊乱，例如混合性或糖尿病性血脂异常，高脂血症，高胆固醇血症和 高甘油三酯血症。
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9.发明授权TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权TETRA CYCLICAL呫吨和使用方法进行病毒疾病治疗
公开(公告)号：EP2685984B1
公开(公告)日：2016-11-02
申请号：EP12757005.9
申请日：2012-03-16
发明人： COBURN, Craig A. , ROSENBLUM, Stuart B. , KOZLOWSKI, Joseph A. , SOLL, Richard , WU, Hao , HU, Bin , ZHONG, Bin , WANG, Dahai , SHEN, Changmao , SUN, Fei
IPC分类号： A61K31/5383 , C07D491/06 , C07D493/06 , C07D498/06
CPC分类号： A61K31/5383 , A61K31/4178 , A61K45/06 , C07D491/06 , C07D493/06 , C07D498/06
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公开(公告)号：EP3082786A1
公开(公告)日：2016-10-26
申请号：EP14870903.3
申请日：2014-12-17
发明人： HAGMANN, William, K. , LI, Bing , SZEWCZYK, Jason, W. , WANG, Bowei , PARKER, Dann , BLIZZARD, Timothy , JOSIEN, Hubert , BIJU, Purakkattle , CHOBANIAN, Harry , GUDE, Candido , NARGUND, Ravi, P. , PIO, Barbara , DANG, Qun , LIN, Linus, S. , HU, Bin , CUI, Mingxiang , CHEN, Zhengxia , DAI, Meibi , ZHANG, Zaihong , LV, Ying , TIAN, Lili
IPC分类号： A61K31/192 , A61K31/381
CPC分类号： C07D493/04 , A61K31/437 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/46 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/64 , C07D213/74 , C07D221/20 , C07D239/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D451/06 , C07D471/04
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
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