公开(公告)号：EP0596700A1

公开(公告)日：1994-05-11

申请号：EP93308746.2

申请日：1993-11-02

申请人： Hewlett-Packard Company

发明人： Robotti, Karla M.

IPC分类号： G01N33/52 ,  G01N33/66 ,  C09B69/10 ,  C09B46/00 ,  C09B31/00

CPC分类号： G01N33/66 ,  C09B29/0007 ,  G01N31/22

摘要： The present invention is directed to methods and kits for measurement of cis-diols in a sample by means of dyes which produce a spectral change upon reaction or complexation with cis-diols. The present invention is also directed to solid supports having such dyes as substituents thereon. In particular, measurement of glucose using azo boronic dyes is disclosed.

摘要翻译： 本发明涉及用于通过在与顺式二醇反应或与顺式二醇络合时产生光谱变化的染料测量样品中顺式二醇的方法和试剂盒。 本发明还涉及具有这样的染料作为其上的取代基的固体支持物。 特别地，公开了使用偶氮硼染料测量葡萄糖。

公开(公告)号：EP0287909B1

公开(公告)日：1992-09-02

申请号：EP88105653.5

申请日：1988-04-08

申请人： SALUTAR, INC.

发明人： Quay, Steven C. ,  Rocklage, Scott M. ,  Miller, Warren

IPC分类号： C07C309/28 ,  C09B46/00 ,  A61K49/02 ,  C07D277/66

CPC分类号： G01N33/6896 ,  A61K51/0406 ,  A61K2123/00 ,  C07C309/47 ,  C07C309/50 ,  C07D277/66 ,  C09B29/0003 ,  C09B29/0011 ,  C09B29/30 ,  C09B35/08 ,  C09B35/16 ,  C09B35/20 ,  C09B43/40 ,  G01N2800/2821

公开(公告)号：EP2173827A4

公开(公告)日：2011-09-28

申请号：EP08783284

申请日：2008-07-24

申请人： AMERICAN DYE SOURCE INC

发明人： NGUYEN MY T ,  LOCAS MARC ANDRE

IPC分类号： C09D151/06 ,  B41C1/10 ,  B41M5/36 ,  C09B46/00 ,  C09B69/10 ,  C09D5/32 ,  C09D137/00

CPC分类号： B41C1/1016 ,  B41C2201/02 ,  B41C2201/10 ,  B41C2201/14 ,  B41C2210/04 ,  B41C2210/08 ,  B41C2210/22 ,  B41C2210/24 ,  C08F290/06 ,  C08F290/061 ,  C08L33/12 ,  C08L2205/22 ,  C09B69/106 ,  C09B69/109 ,  C09D5/024 ,  C09D139/04 ,  Y10T428/25 ,  Y10T428/31504 ,  Y10T428/31935 ,  C08L2666/04

公开(公告)号：EP2173827A1

公开(公告)日：2010-04-14

申请号：EP08783284.6

申请日：2008-07-24

申请人： American Dye Source, Inc.

发明人： NGUYEN, My T. ,  LOCAS, Marc, André

IPC分类号： C09D151/06 ,  B41C1/10 ,  B41M5/36 ,  C09B46/00 ,  C09D137/00 ,  C09D5/32

CPC分类号： B41C1/1016 ,  B41C2201/02 ,  B41C2201/10 ,  B41C2201/14 ,  B41C2210/04 ,  B41C2210/08 ,  B41C2210/22 ,  B41C2210/24 ,  C08F290/06 ,  C08F290/061 ,  C08L33/12 ,  C08L2205/22 ,  C09B69/106 ,  C09B69/109 ,  C09D5/024 ,  C09D139/04 ,  Y10T428/25 ,  Y10T428/31504 ,  Y10T428/31935 ,  C08L2666/04

摘要： A thermal lithographic printing plate overcoat composition comprising (a) a water- soluble polymeric dye having an absorption band between about 300 and about 600 nm; and (b) micro-particles or nano-particles is provided. A negative-working thermal lithographic printing plate comprising (a) a hydrophilic substrate; (b) a near infrared imaging layer disposed on the hydrophilic substrate; and (c) an overcoat layer disposed on the imaging layer, said overcoat layer comprising a water-soluble polymeric dye having an absorption band between about 300 and about 600 nm; and micro-particles or nano-particles is also provided. Finally, a water-soluble polymeric dye having an absorption band between about 300 and about 600 nm is provided.

公开(公告)号：EP3116954A4

公开(公告)日：2017-11-15

申请号：EP15761120

申请日：2015-03-12

申请人： HENRY M JACKSON FOUND ADVANCEMENT MILITARY MEDICINE INC

发明人： DALGARD CLIFTON ,  MOHAMED AHMED ,  SRIVASTAVA MEERA ,  SRIVASTAVA SHIV

IPC分类号： C09B46/00 ,  A61K31/135 ,  A61K31/136 ,  A61K31/426 ,  A61K31/4402 ,  A61K45/06 ,  A61P35/00 ,  C09B29/42 ,  C09B33/00 ,  C09B35/02

CPC分类号： A61K31/4402 ,  A61K31/135 ,  A61K31/136 ,  A61K31/426 ,  A61K45/06 ,  C09B29/28 ,  C09B67/009

摘要： Alterations to the ERG gene are some of the most prominent genomic changes associated with many cancers including prostate cancer. Such cancer specific alterations result in the overexpression of wild type ERG protein or an altered ERG protein. The present invention provides selective inhibitors of wild type or an altered ERG protein expression. The ERG inhibitors of the invention, therefore, are therapeutic agents for treating ERG positive cancers.

公开(公告)号：EP3116954A1

公开(公告)日：2017-01-18

申请号：EP15761120.3

申请日：2015-03-12

申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： DALGARD, Clifton ,  MOHAMED, Ahmed ,  SRIVASTAVA, Meera ,  SRIVASTAVA, Shiv

IPC分类号： C09B46/00 ,  C09B29/42 ,  C09B33/00 ,  C09B35/02

摘要： Alterations to the ERG gene are some of the most prominent genomic changes associated with many cancers including prostate cancer. Such cancer specific alterations result in the overexpression of wild type ERG protein or an altered ERG protein. The present invention provides selective inhibitors of wild type or an altered ERG protein expression. The ERG inhibitors of the invention, therefore, are therapeutic agents for treating ERG positive cancers.

摘要翻译： 对ERG基因的改变是与许多癌症（包括前列腺癌）相关的一些最突出的基因组变化。 这种癌症特异性改变导致野生型ERG蛋白或改变的ERG蛋白的过度表达。 本发明提供野生型选择性抑制剂或改变的ERG蛋白表达。 因此，本发明的ERG抑制剂是用于治疗ERG阳性癌症的治疗剂。

公开(公告)号：EP0287909A1

公开(公告)日：1988-10-26

申请号：EP88105653.5

申请日：1988-04-08

申请人： SALUTAR, INC.

发明人： Quay, Steven C. ,  Rocklage, Scott M. ,  Miller, Warren

IPC分类号： C07C309/28 ,  C09B46/00 ,  A61K49/02 ,  C07D277/66

CPC分类号： G01N33/6896 ,  A61K51/0406 ,  A61K2123/00 ,  C07C309/47 ,  C07C309/50 ,  C07D277/66 ,  C09B29/0003 ,  C09B29/0011 ,  C09B29/30 ,  C09B35/08 ,  C09B35/16 ,  C09B35/20 ,  C09B43/40 ,  G01N2800/2821

摘要： The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably ¹²³I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects or the invention.

摘要翻译： 淀粉样蛋白沉积物在患者的器官或身体区域中的存在和位置通过静脉内施用新的放射性碘标记的淀粉样蛋白结合化合物并且优选<1> 2> 3 I-标记的化合物给患者和感测 从器官或身体区域发射的辐射。 易于碘化的新型非放射性碘取代淀粉样结合化合物和淀粉样蛋白结合化合物是其它方面或本发明。