公开(公告)号：EP4430162A1

公开(公告)日：2024-09-18

申请号：EP22817145.0

申请日：2022-11-09

申请人： Technische Universität Dresden

发明人： RUIZ BABOT, Gerard ,  BORNSTEIN, Stefan R.

IPC分类号： C12N5/071 ,  A61K35/22

CPC分类号： C12N5/0614 ,  C12N2500/6220130101 ,  C12N2500/9020130101 ,  C12N2501/11520130101 ,  C12N2501/15520130101 ,  C12N2501/38520130101 ,  C12N2501/72720130101 ,  C12N2501/6020130101 ,  C12N2506/0220130101 ,  C12N2506/4520130101 ,  C12N2510/0020130101 ,  A61K35/22

公开(公告)号：EP4243837A1

公开(公告)日：2023-09-20

申请号：EP21892912.3

申请日：2021-11-12

申请人： Bertram, Timothy, A. ,  Jain, Deepak

发明人： Bertram, Timothy, A. ,  Jain, Deepak

IPC分类号： A61K35/12 ,  A61K35/22 ,  C12N5/07 ,  C12Q1/02 ,  C12Q1/68

公开(公告)号：EP4229181A1

公开(公告)日：2023-08-23

申请号：EP21882324.3

申请日：2021-10-19

申请人： Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： DEKEL, Benjamin ,  OMER, Dorit ,  HARARI-STEINBERG, Orit

IPC分类号： C12N5/071 ,  A61K35/22 ,  G01N33/50

公开(公告)号：EP2892997B1

公开(公告)日：2021-03-17

申请号：EP13835201.8

申请日：2013-09-10

发明人： ZHANG, Yuanyuan ,  OPARA, Emmanuel, C.

IPC分类号： C12N5/00 ,  C12N5/0775 ,  A61K38/18 ,  A61K9/00 ,  A61K9/16 ,  A61K35/22 ,  A61K35/545 ,  C12N5/071

公开(公告)号：EP3693033A1

公开(公告)日：2020-08-12

申请号：EP18864482.7

申请日：2018-10-01

申请人： GN Corporation Ltd ,  JBM Incorporation

发明人： YOSHIOKA Hiroshi ,  Samuel Abraham JK

IPC分类号： A61L31/04 ,  A61K9/08 ,  A61K35/22 ,  A61K35/38 ,  A61K47/30 ,  A61L31/14 ,  A61L31/16 ,  A61P13/02

摘要： [Object]
The present invention is intended to provide a urethral stricture treatment agent and a urethral stricture treatment method capable of avoiding restenosis by a less invasive transurethral endoscopic procedure in urethral stricture treatment.
[Solution]
A urethral stricture treatment agent including at least a hydrogel-forming polymer, and having a storage elastic modulus of 50 Pa or less at 10°C and a storage elastic modulus of 100 Pa or more at 37°C.
A urethral stricture treatment method at least including injecting the urethral stricture treatment agent cooled to 10°C or lower into an inner surface of urethra which has been incised with a transurethral endoscopic procedure, and holding the urethral stricture treatment agent in the inner surface of urethra at a temperature not lower than a room temperature.
[Selected Drawing]
None

公开(公告)号：EP3020803B1

公开(公告)日：2020-03-11

申请号：EP14811223.8

申请日：2014-06-11

申请人： Kyoto University ,  Astellas Pharma Inc.

发明人： OSAFUNE, Kenji ,  TOYOHARA, Takafumi ,  YAMAGISHI, Yukiko

IPC分类号： C12N5/07 ,  A61L27/00 ,  A61P13/12 ,  C12N5/077 ,  A61K35/22 ,  A61K38/18 ,  A61P31/12

公开(公告)号：EP2055325B1

公开(公告)日：2019-07-17

申请号：EP09152183.1

申请日：2000-12-20

申请人： Acell, Inc.

发明人： Spievack, Alan R

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61K35/38 ,  A61K35/36 ,  A61K35/22

公开(公告)号：EP2864474B1

公开(公告)日：2018-08-22

申请号：EP13739622.2

申请日：2013-06-21

申请人： Brandenburgische Technische Universität Cottbus-Senftenberg

发明人： ANDERER, Ursula ,  LEHMANN, Mario ,  MARTIN, Frank

IPC分类号： C12N5/077 ,  A61F2/28 ,  A61F2/30 ,  A61K35/22 ,  A61K35/28 ,  A61K35/34 ,  A61K35/407 ,  A61L27/38

CPC分类号： C12N5/0655 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61K35/22 ,  A61K35/28 ,  A61K35/34 ,  A61K35/407 ,  A61L27/3817 ,  A61L27/3895 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0654 ,  C12N2513/00

公开(公告)号：EP3294305A1

公开(公告)日：2018-03-21

申请号：EP16797058

申请日：2016-05-14

申请人： CARILION CLINIC

发明人： GLEASON JONATHAN L ,  GREER WILLIAM J

IPC分类号： A61K35/22 ,  A61K35/74 ,  A61K39/08 ,  A61M5/31 ,  A61M5/315

CPC分类号： A61K9/0034 ,  A61K9/0019 ,  A61K38/4893 ,  A61M5/31595 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/582 ,  C12Y304/24069

摘要： Certain configurations are directed to a syringe configured to provide tactile feedback and that permits injection of a plurality of individual metered volumes. In some embodiments, the syringe can be used to inject a metered volume of a botulinum toxin at each of a plurality of separate sites of a bladder wall to treat overactive bladder.

公开(公告)号：EP2031968B1

公开(公告)日：2017-11-22

申请号：EP07755875.7

申请日：2007-04-20

申请人： Wake Forest University Health Sciences

发明人： VAN DYKE, Mark, E. ,  CHRIST, George ,  WHITLOCK, Patrick

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  A61K35/22 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/39 ,  A61K35/407 ,  A61K35/44

CPC分类号： A61L27/56 ,  A61K35/22 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/39 ,  A61K35/407 ,  A61K35/44 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/38 ,  A61L2430/40 ,  C12N5/0068 ,  C12N2533/90

摘要： Methods are provided for producing a bioscaffold from natural tissues by oxidizing a decellularized tissue to produce a bioscaffold having pores therein. The pore size and porosity is increased to better accommodate intact cells so that live cells can better infiltrate and inhabit the bioscaffold. The bioscaffold may be freeze-dried or lyophilized, sterilized and (optionally) aseptically packaged for subsequent use. A further aspect of the present invention is a bioscaffold produced by the processes described herein. Methods of treatment using the bioscaffold as a graft or as a biomedical implant for implantation are also provided. Also provided are methods of seeding a bioscaffold with mammalian cells, wherein the seeding carried out either in vitro or in vivo, and wherein a bioscaffold produced as described herein is utilized for said seeding.