CLINICAL-GRADE AUTOLOGOUS BRONCHIAL BASAL CELL, TRANSFUSION FORMULATION, AND PREPARATION PROCESS

    公开(公告)号:EP3954760A1

    公开(公告)日:2022-02-16

    申请号:EP20806297.6

    申请日:2020-05-15

    发明人: ZHANG, Ting

    IPC分类号: C12N5/074 A61K35/42 A61P11/08

    摘要: Provided are a clinical-grade autologous bronchial basal cell, a transfusion formulation thereof, and a preparation process. The preparation process comprises the following steps: extracting in vitro active bronchial brush biopsy tissue for digestive treatment, and collecting cells after digestion is terminated; performing plating culture on the digested cells by using a culture plate having trophoblast cells plated thereon, collecting cells, performing amplification culture on the digested cells by using a culture plate having trophoblast cells plated thereon, and when cells grow to cover 50%-90% of the surface area of the culture plate, performing secondary culture; and when secondary culture cells grow to cover 85%-95% of the surface area of a culture dish, digesting and collecting adhered cells, and washing. The prepared bronchial basal cell can be used for repairing damaged lung tissue.

    COMPOSITION FOR RELIEVING AND TREATING BURNS AND BEDSORES

    公开(公告)号:EP3650032A2

    公开(公告)日:2020-05-13

    申请号:EP18828213.1

    申请日:2018-07-04

    发明人: CHOI, Seong Hyun

    IPC分类号: A61K35/42 A61K31/192

    摘要: The present invention relates to a composition for relieving and treating burns and bedsores comprising the animal lung tissue extract as an active ingredient, wherein the composition of the present invention suggests that the protective effect of animal lung tissue extract and/or propionic acid on skin damage is related to not only inflammation inhibition but also regeneration and angiogenesis of fibrous tissues. It can be used as a therapeutic agent for these diseases by exhibiting industrially available effects related to the treatment of burns and bedsores.

    HUMAN LUNG STEM CELLS AND USES THEREOF
    7.
    发明授权
    HUMAN LUNG STEM CELLS AND USES THEREOF 有权
    人肺干细胞及其用途

    公开(公告)号:EP2624847B1

    公开(公告)日:2017-09-13

    申请号:EP11831492.1

    申请日:2011-10-05

    摘要: Embodiments of the invention relate to human stem cells and their therapeutic use in the treatment and/or prevention of lung diseases. Provided herein are compositions comprising c-kit positive human lung stem cells and methods of preparing and using c-kit positive human lung stem cells for the treatment and/or prevention of lung diseases.

    摘要翻译: 本发明的实施方案涉及人类干细胞及其在治疗和/或预防肺部疾病中的治疗用途。 本文提供了包含c-kit阳性人肺干细胞的组合物以及制备和使用c-kit阳性人肺干细胞用于治疗和/或预防肺疾病的方法。

    APPARATUS FOR EXTRACORPOREAL CELLULAR THERAPY OF LUNG OR OTHER ORGAN
    8.
    发明公开
    APPARATUS FOR EXTRACORPOREAL CELLULAR THERAPY OF LUNG OR OTHER ORGAN 审中-公开
    VORRICHTUNG ZUR EXTRAKORPORALEN ZELLTHERAPIE DER LUNGE ODER ANDERER ORGANE

    公开(公告)号:EP2906232A4

    公开(公告)日:2016-09-28

    申请号:EP13847671

    申请日:2013-10-15

    IPC分类号: A61K35/42

    摘要: This application describes an apparatus and a method for the treatment of a damaged lung, heart, or other organ or tissue using cells contained in the apparatus and a liquid interface that allows communication with the circulation of the damaged organ or tissue. The apparatus can be used to treat the organ inside or outside the body. The apparatus is designed to sit outside the body but a similar apparatus is envisioned that is implantable. The apparatus contains a porous material or matrix that the cells are grown on, and the volume of the apparatus provides that it can contain a therapeutically useful number of cells in the range 0.5×10e6 to 200×10e6.

    摘要翻译: 本申请描述了使用装置中包含的细胞和允许与损伤的器官或组织的循环连通的液体界面来治疗损伤的肺,心脏或其他器官或组织的装置和方法。 该装置可用于在体内或体外处理器官。 该设备被设计成坐在身体外部,但是可以设想到可植入的类似装置。 该装置包含细胞在其上生长的多孔材料或基质,并且该装置的体积使得其可以含有0.5×10e6至200×10e6范围内的治疗有用数量的细胞。