公开(公告)号：EP2821386B1

公开(公告)日：2022-08-17

申请号：EP14180362.7

申请日：2010-09-16

发明人： Dalko, Maria

IPC分类号： A01N31/16 ,  A01P1/00 ,  A01P3/00 ,  C07C49/245 ,  A61K8/35 ,  A61K47/10 ,  A61Q19/00 ,  C07C49/255

公开(公告)号：EP2655307B1

公开(公告)日：2018-08-01

申请号：EP11805863.5

申请日：2011-12-23

申请人： Givaudan SA

发明人： BAUMGARTNER, Corinne ,  FLACHSMANN, Felix ,  KRAFT, Philip

IPC分类号： C07C45/34 ,  C07C47/575 ,  C07C47/21 ,  C07C47/228 ,  C07C47/54 ,  C07C49/245 ,  C07C49/788 ,  C07C15/44 ,  C07C15/50 ,  C07C15/58 ,  C07C43/23 ,  C07C43/215 ,  C07D317/50 ,  C07D317/54 ,  C11D3/50 ,  C11B9/00

CPC分类号： C11B9/0015 ,  C07C15/44 ,  C07C15/50 ,  C07C15/58 ,  C07C43/215 ,  C07C43/23 ,  C07C45/34 ,  C07D317/50 ,  C07D317/54 ,  C11B9/0003 ,  C11B9/0053 ,  C11B9/0061 ,  C11B9/0076 ,  C11D3/507 ,  C07C47/575 ,  C07C47/21 ,  C07C49/245 ,  C07C49/788 ,  C07C47/228 ,  C07C47/54

摘要： Provided is class of compounds of formula (I) wherein X, R1, R2 and R3 have the same meaning as given in the specification capable of releasing fragrant compounds in a controlled manner into the surroundings.

公开(公告)号：EP2483228A1

公开(公告)日：2012-08-08

申请号：EP10770573.3

申请日：2010-09-16

申请人： L'Oréal

发明人： DALKO, Maria

IPC分类号： C07C49/245 ,  A61K8/35 ,  A61K47/10

CPC分类号： C07C49/255 ,  A61K8/35 ,  A61K47/10 ,  A61K2800/524 ,  A61Q19/00

摘要： The present invention relates to the use, in a cosmetic, dermatological, or pharmaceutical composition, of at least one compound of formula (I), where: R2 is a hydrogen atom or a methyl or ethyl radical; and R3 is a C
1 -C
12 straight alkyl radical, optionally substituted by a hydroxyl group, or a C
2 -C
12 straight alkenyl radical, optionally substituted by a hydroxyl group as a preservative agent. The invention also relates to certain novel compounds and to the cosmetic, dermatological, or pharmaceutical compositions including same.

公开(公告)号：EP1738824A4

公开(公告)日：2009-11-11

申请号：EP05720221

申请日：2005-03-08

申请人： JAPAN SCIENCE & TECH AGENCY

发明人： KOBAYASHI SHU ,  AKIYAMA RYO ,  KAWAI NOBUYUKI ,  TAKEUCHI MASAHIRO

IPC分类号： B01J31/26 ,  B01J13/08 ,  B01J31/16 ,  B01J31/28 ,  C07C45/46 ,  C07C45/51 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/255 ,  C07C49/507 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C67/347 ,  C07C227/12 ,  C07C229/34 ,  C07C327/22

CPC分类号： C07C67/347 ,  B01J13/14 ,  B01J31/165 ,  B01J31/2239 ,  B01J31/226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/842 ,  B01J2540/22 ,  C07C45/46 ,  C07C45/511 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C227/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  Y02P20/584 ,  C07C69/732 ,  C07C69/738 ,  C07C69/757 ,  C07C229/34

公开(公告)号：EP1903024A1

公开(公告)日：2008-03-26

申请号：EP07253498.5

申请日：2007-09-04

申请人： Gharda Chemicals Limited

发明人： Gharda, Keki Horsmusji ,  Malte, Ashokkumar Maganlal ,  Mathur, Suchet Saran ,  Joseph, Pulinattu Cherian ,  Mathew, Abraham

IPC分类号： C07C45/84 ,  C07C49/245 ,  C08G65/40

CPC分类号： C08G65/4075 ,  C07C45/46 ,  C07C45/84 ,  C07C49/83

摘要： 4-Chloro-4'-hydroxybenzophenone - preferably prepared by reaction of 4-chlorobenzoyl chloride and phenol using AlCl 3 catalyst in orthodichlorobenzene solvent - is purified by distillation under vacuum, more conveniently in combination with a solvent such as diphenyl sulfone, to give a high purity monomer which can be polymerized, using, e.g.,K 2 CO 3 at 330°C, to yield poly(ether ketone) - PEK - with excellent properties.

摘要翻译： 4-氯-4'-羟基二苯甲酮 - 优选通过4-氯苯甲酰氯和苯酚在邻二氯苯溶剂中，使用三氯化铝催化剂反应制备 - 通过在真空下蒸馏纯化，更方便地在与溶剂的组合：如二苯基砜，得到 其中高纯度的单体可被聚合，使用，例如，K 2 CO 3在330℃下，以得到聚（醚酮） - PEK - 具有优异性能。

公开(公告)号：EP1189897B1

公开(公告)日：2006-10-18

申请号：EP00920273.0

申请日：2000-05-01

申请人： G.J. Consultants Pty Ltd

发明人： JOANNOU, George, Eustace

IPC分类号： C07D311/38 ,  C07C49/245 ,  C07C49/248 ,  C07C49/747 ,  C12N1/00 ,  A23L1/30 ,  A61K31/353 ,  A61P35/00 ,  C07D311/58

CPC分类号： C07C45/673 ,  A23L33/105 ,  A23L33/11 ,  A61K31/352 ,  C07C45/46 ,  C07C45/62 ,  C07C45/75 ,  C07C49/747 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D311/38 ,  C07D311/58

摘要： There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and ----- denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.

公开(公告)号：EP1056700B1

公开(公告)日：2006-09-20

申请号：EP98967135.9

申请日：1998-10-20

申请人： ZingoTX Pty Ltd

发明人： ROUFOGALIS, Basil, Don ,  DUKE, Colin, Charles ,  TRAN, Van, Hoan

IPC分类号： C07C43/23 ,  C07C49/245 ,  C07C49/255 ,  C07C49/84 ,  A61K31/05 ,  A61K31/085 ,  A61K31/12

CPC分类号： C07D317/54 ,  A61K31/05 ,  A61K31/085 ,  A61K31/12 ,  C07C43/23 ,  C07C45/292 ,  C07C45/62 ,  C07C45/66 ,  C07C45/673 ,  C07C45/71 ,  C07C45/72 ,  C07C45/73 ,  C07C45/74 ,  C07C49/245 ,  C07C49/255 ,  C07C49/84 ,  C07C47/575 ,  C07C47/277

摘要： A compound of formula (I), a pharmaceutically acceptable derivative thereof, wherein Ph is a phenyl radical R1 is H, OH, OC1-4alkyl, NO2; R2 is OH, OC1-4alkyl, OC=OC1-4alkyl or OC=OPh where the Ph can be optionally substituted by halogen, C1-3 alkyl or NO2; R¿1 and R2 along with the two carbon atoms of the phenyl ring to which they are attached can combine to form a 5 or 6 membered heterocyclic ring comprising 1 or 2 heteroatoms selected from O, S or N; R3 is an optionally substituted hydrocarbyl radical; R4 is H, CH3, OH or =O; when R4 is =O, then the carbon to which R4 is attached is not bonded to H; W is C(=O)-CH2, CH=CH-, CH2CO, CH(OH)-CH2, C(CH3)(OH)CH2, CH2CH(OH), CH2C(CH3)OH, CO, CHOH, C(CH3)(OH), CH2, CH2CH2; X is -CH-OH, C(CH3)OH, CH2, CH(CH3) or -C=O; Y is -CH-OH, C(CH3)OH, CH2, CH(CH3) or -C=O; provided that one of W, X or Y has an OH group.

公开(公告)号：EP1240347A1

公开(公告)日：2002-09-18

申请号：EP00984642.9

申请日：2000-12-13

申请人： VICTORIA UNIVERSITY OF TECHNOLOGY ,  Polychip Pharmaceuticals Pty. Ltd.

发明人： SMALLRIDGE, Andrew, John ,  TREWHELLA, Maurice, Arthur ,  WILKINSON, Kylie, Anne

IPC分类号： C12P7/26 ,  C12P7/28 ,  C07C45/45 ,  C07C49/245

CPC分类号： C12P7/26 ,  Y02P20/544

摘要： The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supercritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.

公开(公告)号：EP0454863B1

公开(公告)日：1993-11-03

申请号：EP90916804.9

申请日：1990-11-15

申请人： NIPPON SODA CO., LTD.

发明人： TSUKASHIMA, K. Takaoka Plant, Nippon Soda Co., Ltd ,  KANEKO, Akira Takaoka Plant, Nippon Soda Co., Ltd.

IPC分类号： C07C45/72 ,  C07C49/17 ,  C07C49/172 ,  C07C49/245 ,  C07C323/22 ,  C07D335/02 ,  C07D309/06 ,  C07D307/46

CPC分类号： C07D335/02 ,  C07C45/72 ,  C07C201/12 ,  C07C319/20 ,  C07C2601/14 ,  C07D309/06 ,  C07C49/17 ,  C07C49/245 ,  C07C49/172 ,  C07C323/22 ,  C07C205/45

摘要： The present invention relates to a method for the preparation of β-hydroxyketones represented by general formula (I), (where R is an alkyl group which may have a methyl group at the α position, an alkyl group substituted by alkylthio group which may have a methyl group at the α position, an alicyclic group which may have substituents at positions other than the α, β and β' positions, a heterocyclic group which may have substituents at positions other than the α, β and β' positions, and phenyl group which may have an electron withdrawing group at the para position), by reacting aldehydes represented by formula (A): RCHO (where R is as defined above) with aqueous solution of alkali metal salt of acetoacetic acid represented by formula (B) (where M+ is an alkali metal ion), a method for the preparation of the said β-hydroxyketones which comprises reacting (A) and (B) when a mole ratio of (A) to (B) is 1.0 to 1.5 if (A) has two hydrogen atoms, 1.5 to 2.0 if one hydrogen atom, 2.0 to 2.5 if no hydrogen atoms and 1.1 to 1.5 if R is a phenyl group with electron withdrawing group at the para position even if no hydrogen atoms, at a pH of 9 to 10.

公开(公告)号：EP0271307B1

公开(公告)日：1992-01-02

申请号：EP87310757.7

申请日：1987-12-08

申请人： HOECHST CELANESE CORPORATION

发明人： Aslam, Mohammad ,  Graham, R. Russell ,  Davenport, Kenneth G.

IPC分类号： C07C321/26 ,  C07C323/18 ,  C07C327/02 ,  C07C49/245

CPC分类号： C07C323/00 ,  C07C45/46 ,  C07C45/54 ,  C07C327/00