公开(公告)号：EP4219439A3

公开(公告)日：2023-08-09

申请号：EP23150103.2

申请日：2020-01-29

申请人： Archer Daniels Midland Company

发明人： Albrecht, Karl O. ,  Brazdil, James F.

IPC分类号： C07C51/235 ,  C07C55/06 ,  C07C55/12 ,  C07C59/10 ,  C07C59/105 ,  C07C59/285

摘要： Various processes for preparing aldaric acids, aldonic acids, uronic acids, and/or lactone(s) thereof are described. For example, processes for preparing a C 2 -C 7 aldaric acid and/or lactone(s) thereof by the catalytic oxidation of a C 2 -C 7 aldonic acid and/or lactone(s) thereof and/or a C 2 -C 7 aldose are described.

公开(公告)号：EP2644588A3

公开(公告)日：2013-12-25

申请号：EP13173408.9

申请日：2007-05-24

申请人： Phenomenome Discoveries Inc.

发明人： Cook, Lisa ,  Goodenowe, Dayan

IPC分类号： C07C59/62 ,  C07C235/08 ,  C07C59/105 ,  C07D311/72 ,  C07F9/09 ,  C07F9/10 ,  G01N33/483 ,  G01N33/487 ,  G01N33/50

CPC分类号： C07F9/103 ,  C07C59/46 ,  C07C59/62 ,  C07C235/08 ,  C07C2601/16 ,  C07D311/72 ,  C07F9/106 ,  G01N33/53 ,  G01N33/564 ,  G01N33/6848 ,  G01N33/6893 ,  G01N33/72 ,  G01N2800/28 ,  G01N2800/285 ,  G01N2800/56

摘要： The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis. The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsing-remitting or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis. A method is also provided for the differential diagnosis of subjects afflicted with relapsing-remitting multiple sclerosis from secondary-progressive multiple sclerosis.

摘要翻译： 本发明描述了用于多发性硬化症的不同形式的诊断和鉴别诊断的方法。 该方法测量了具有临床诊断为复发或复发性多发性硬化症的患者的样本中特异性小分子称为代谢物的强度，并将这些强度与健康个体群体观察到的强度进行比较，从而鉴定出多发性硬化症 。 还提供了用于对来自继发性进行性多发性硬化症的复发性多发性硬化症患者的鉴别诊断的方法。

公开(公告)号：EP1477468B1

公开(公告)日：2010-06-23

申请号：EP03701850.4

申请日：2003-01-23

申请人： Japan Science and Technology Agency ,  National Institute of Advanced Industrial Science and Technology

发明人： TANAKA, Masato ,  SATO, K. Tsukuba Center of National Institute of ,  USUI, Yoko Vila Progress 202

IPC分类号： C07C29/03 ,  C07C31/20 ,  C07C31/22 ,  C07C35/06 ,  C07C35/08 ,  C07C51/367 ,  C07C59/105 ,  C07B61/00

CPC分类号： C07C51/367 ,  C07C29/48 ,  C07C2601/08 ,  C07C2601/14 ,  C07C35/14 ,  C07C31/20 ,  C07C35/06 ,  C07C59/105 ,  C07C35/08 ,  C07C31/225

摘要： A process for producing a 1,2-diol through the reaction of an olefin with hydrogen peroxide. The process is highly efficient and highly selective and catalyst recovery and reuse are easy. It does not use any strong acid or strong base causative of apparatus corrosion. The process for producing a 1,2-diol is characterized by reacting an olefin with hydrogen peroxide in the presence of a polymer having a sulfo group.

公开(公告)号：EP2179982A2

公开(公告)日：2010-04-28

申请号：EP08794030.0

申请日：2008-06-30

申请人： Konygin, Grigory Nikolaevich ,  Strelkov, Nikolaj Sergeevich ,  Rybin, Dmitriy Stanislavovich

发明人： POZDEEV, Viktor Vladimirovich ,  YELSUKOV, Evgeny Petrovich ,  SHARAFUTDINOVA, Dilara Rashiovna ,  EFREMOV, Yuri Yakovlevich ,  PETUKHOV, Vladimir Yurievich ,  GUMAROV, Gabdrauf Gabdrashitovich

IPC分类号： C07C59/105 ,  C07C51/00 ,  C07C51/41 ,  C07C51/43 ,  A61K31/191 ,  A61P3/02 ,  A61P3/14

CPC分类号： C07C59/105 ,  C07B2200/13

摘要： The invention relates to the creation of mechanically activated amorphous and amorphocrystalline compounds and compositions of a gluconic acid calcium salt, pharmaceutical preparations based thereon, a method for producing same and use for treatment of a wide range of diseases caused by disorders of calcium metabolism in an organism. A concept of the invention, as being claimed and as set forth in the application, consists in that the crystalline gluconic acid calcium salt or its compound with excipients is treated in grinding activator devices either up to the input specific energy value of not greater than 10.4 kJ/g and achieving an amorphocrystalline state or up to the input specific energy value of no less than 10.5 kJ/g and achieving an amorphous state. The obtainable agents are assessed by means of X-ray diffraction, IR, NMR, EPR spectroscopy, mass- or chromato-mass-spectrometry, and a differential thermal analysis. The mechanically activated amorphous and amorphocrystalline compounds and compositions are used as an active principle for preparing pharmaceutical preparations used for therapeutic, therapeutic-preventive and hygienic purposes. The pharmaceutical preparations comprising a therapeutically effective amount of active ingredient are used perorally 1-6 times daily, in dosages of 0.2-6 g, a course of at least 1 month. The invention can be used in medical and food industries in the production of biologically active agents, therapeutic-prophylactic means, medicinals and in practical medicine in treatment of acute osseous, dental and other diseases related to disorders of calcium metabolism in the organism.

摘要翻译： 本发明涉及机械的创建活化的无定形和非晶形晶体化合物和葡萄糖酸钙盐的组合物，药物制剂基于其，制造方法相同，并使用用于治疗由钙代谢在的紊乱引起的宽范围的疾病的 有机体。 本发明的概念，作为被要求保护的并且如在应用程序阐述，besteht DASS DER晶体葡萄糖酸钙盐或其与赋形剂化合物在研磨活化器装置要么到不大于4.10的输入特定能量值被视为 千焦/克，并在非晶形晶体状态或至多不小于10.5千焦/克的特定输入能量值实现和非晶状态实现。 所得到的阿剂通过X射线衍射，IR，NMR，EPR光谱，裁缝或色谱 - 质谱法，和差示热分析来评估。 所述机械活化的无定形和非晶形晶体化合物和组合物在用于用于治疗，治疗-预防和卫生目的的药物制剂的制备中用作活性成分。 该药物制剂包含治疗有效量的活性成分的每日使用口服1-6次，以0.2-6克的剂量，至少1个月的过程。 本发明可以在医疗和食品工业中治疗急性骨，牙齿和与在生物体钙代谢紊乱的其它疾病的可用于生产生物活性剂，治疗 - 预防手段，药物中的并在实际药物。

公开(公告)号：EP1807383A2

公开(公告)日：2007-07-18

申请号：EP05791966.4

申请日：2005-10-06

申请人： QUEST INTERNATIONAL B.V.

发明人： WINKEL, Chris ,  RENES, Harry

IPC分类号： C07C59/105 ,  C07H13/12 ,  A23L1/22 ,  C07H5/06 ,  A23L1/30 ,  A23L1/236 ,  A61K31/7008

CPC分类号： C07H5/06 ,  A23L27/202 ,  A23L27/215 ,  A61K31/7008 ,  C07H13/12

摘要： The present invention in a first aspect relates to novel flavour modulating substances according to formula (I) and/or formula (II) and/or edible salts thereof: R1-CR2(OR3)-CO-NR4-CHR5R6 (I) It was found that substances represented by formula (I) or formula (II) can advantageously be used to impart desirable flavour, especially taste attributes to foodstuffs, beverages, pharmaceutics, tobacco products and oral care products they are incorporated in. In addition said substances are capable of modulating and complementing the sensory impact of other, flavour imparting, substances. Thus, the present flavour modulating substances are advantageously applied in flavour compositions, foodstuffs, beverages, pharmaceutics and oral care products. Typical examples of flavour modulating substances according to the present invention include N-lactoyl glucosamine, N-lactoyl glucosaminic acid, N-gluconyl glucosamine, N- gluconyl glucosaminic acid, hemiacetals or lactones thereof, edible salts thereof and mixtures thereof.

公开(公告)号：EP1261574B1

公开(公告)日：2006-11-02

申请号：EP01918380.5

申请日：2001-03-06

申请人： EASTMAN CHEMICAL COMPANY

发明人： COLLINS, Nick, Allen ,  SHELTON, Mark, Robert ,  TINDALL, George, William ,  PERRI, Steven, Thomas ,  O'MEADHRA, Ruairi, Seosamh ,  SINK, Chester, Wayne ,  ARUMUGAM, Bhaskar, K. ,  HUBBS, John, Clark

IPC分类号： C07C51/43 ,  C07C59/347 ,  C07C59/105 ,  C07C59/265 ,  C07C59/255 ,  C07C59/19 ,  C07C59/08 ,  C07C57/145 ,  C07C55/10 ,  C07C53/02 ,  C07C53/08 ,  C07C53/122 ,  C07C53/124 ,  C07C59/245 ,  C07C57/13 ,  C07D307/62 ,  C07C51/48

CPC分类号： C07C51/43 ,  Y02P20/582 ,  Y10S435/803 ,  Y10S435/876 ,  Y10S435/896 ,  C07C59/347

摘要： A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s). Specific examples of suitable organic acids include, but are not limited to, ascorbic, succinic, tartaric, glyconic, gulonic, citric, lactic, malic, maleic, acetic, formic, gluconic pyruvic, propionic, butyric, itaconic acids and mixtures thereof. One embodiment of the present invention relates to the recovery of 2-keto-L-gulonic acid (KLG) from aqueous solutions such as fermentation baths.

公开(公告)号：EP1588999A2

公开(公告)日：2005-10-26

申请号：EP04030062.6

申请日：2004-12-17

申请人： Malaysian Palm Oil Board

发明人： Ahmad, Salmiah ,  Soi, Hoong Seng ,  Sattar, Mohd Norhisham ,  Yusof, Yusrabbil Amiyati ,  Hassan Hazimah Abu ,  Awang, Roila

IPC分类号： C07C59/105 ,  C07C51/367

CPC分类号： C07C59/105 ,  C07C51/367

摘要： The present invention relates to an improved process for producing hydroxy fatty acids preferably dihydroxy or polyhydroxy acids from unsaturated fatty acids derived from natural oils and fats. The unsaturated fatty acids extracted from natural vegetable oils or animal fats preferably palm-based oleic acid is hydroxylated or oxidized by peracetic acid which formed in situ from a mixture of hydrogen peroxide and formic acid. The process for producing dihydroxy or polyhydroxy fatty acids according to the present invention involve less cost, easier to perform and reduced reaction time. In addition, the dihydroxy or polyhydroxy acids produced according to the present invention is non irritant and suitable to be used in production of cosmetic products.

摘要翻译： 本发明涉及从天然油和脂肪得到的不饱和脂肪酸生产羟基脂肪酸，优选二羟基或多羟基酸的改进方法。 从天然植物油或动物脂肪提取的不饱和脂肪酸，优选棕榈酸油酸，由过氧乙酸和甲酸的混合物原位形成的过乙酸羟化或氧化。 根据本发明的制备二羟基或多羟基脂肪酸的方法涉及成本更低，更容易实施和缩短反应时间。 此外，根据本发明生产的二羟基或多羟基酸是无刺激性的，适用于化妆品的生产。

公开(公告)号：EP0870052B1

公开(公告)日：2005-02-16

申请号：EP96944962.8

申请日：1996-12-20

申请人： GENENCOR INTERNATIONAL, INC.

发明人： LANTERO, Oreste, J. ,  SHETTY, Jayarama, K.

IPC分类号： C12P7/58 ,  C07C59/105 ,  B01J2/02

CPC分类号： C12P7/58 ,  B01J2/006 ,  B01J2/02 ,  B01J2/04 ,  C07C51/42 ,  C07C59/105

摘要： An enzymatic system comprised of glucose oxidase and a catalase of the same or different sources to result in the complete conversion of glucose to gluconic acid at a glucose concentration greater than 25 % (w/w) ds. The resultant gluconic acid, which is essentially free from impurities normally associated with the fermentation process, is then spray granulated to produce a low-dust dry product.

公开(公告)号：EP1477468A1

公开(公告)日：2004-11-17

申请号：EP03701850.4

申请日：2003-01-23

申请人： Japan Science and Technology Agency ,  National Institute of Advanced Industrial Science and Technology

发明人： TANAKA, Masato ,  SATO, K. Tsukuba Center of National Institute of ,  USUI, Yoko Vila Progress 202

IPC分类号： C07C29/03 ,  C07C31/20 ,  C07C31/22 ,  C07C35/06 ,  C07C35/08 ,  C07C51/367 ,  C07C59/105 ,  C07B61/00

CPC分类号： C07C51/367 ,  C07C29/48 ,  C07C2601/08 ,  C07C2601/14 ,  C07C35/14 ,  C07C31/20 ,  C07C35/06 ,  C07C59/105 ,  C07C35/08 ,  C07C31/225

摘要： A process for producing a 1,2-diol through the reaction of an olefin with hydrogen peroxide. The process is highly efficient and highly selective and catalyst recovery and reuse are easy. It does not use any strong acid or strong base causative of apparatus corrosion. The process for producing a 1,2-diol is characterized by reacting an olefin with hydrogen peroxide in the presence of a polymer having a sulfo group.

公开(公告)号：EP0820979A1

公开(公告)日：1998-01-28

申请号：EP97305135.2

申请日：1997-07-11

申请人： CERESTAR HOLDING BV

发明人： Elseviers, Myriam ,  Lemmens, Hilde Odile Jozefine ,  Coomans, Sonia Marianne Jeannine ,  Röper, Harald Wilheolm Walter

IPC分类号： C07C51/235 ,  C07C59/105 ,  C07C29/149 ,  C07C31/18

CPC分类号： C07C29/149 ,  C07B2200/07 ,  C07C51/313 ,  C07C59/105 ,  C07C31/18

摘要： The present invention discloses a method for producing a pentitol. The present invention relates to a method for producing arabinitol from hexoses, e.g galactose and/or glucose, and/or fructose, or lactose hydrolysate, or invert sugar, or starch hydrolysates. The hexose is oxidatively decarboxylated to a C 5 -aldonic acid followed by catalytic hydrogenation yielding the desired arabinitol.

摘要翻译： 本发明公开了一种制备戊糖醇的方法。 本发明涉及从己糖例如半乳糖和/或葡萄糖和/或果糖或乳糖水解产物或转化糖或淀粉水解产物生产阿拉伯糖的方法。 将己糖氧化脱羧为C5-醛糖酸，然后进行催化氢化，得到所需的阿拉伯糖醇。