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    process for producing hydrogenated aromatic polycarboxylic acid and process for producing hydrogenated aromatic polycarboxylic anhydride
    2.
    发明公开
    process for producing hydrogenated aromatic polycarboxylic acid and process for producing hydrogenated aromatic polycarboxylic anhydride 有权
    一种用于生产氢化的芳族多元羧酸和工艺过程制备氢化的芳族Polykarbonsäureanhydrid

    公开(公告)号：EP1323700A1

    公开(公告)日：2003-07-02

    申请号：EP02028941.9

    申请日：2002-12-24

    申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

    发明人： Zaima, Fumiya, c/o Mitsubishi Gas Chem. Co., Inc.

    IPC分类号： C07C51/36 ,  C07C51/56 ,  C07C61/09 ,  C07C61/12 ,  C07C61/125 ,  C07C61/24

    CPC分类号： C07C51/36 ,  C07D307/89 ,  C07C61/08

    摘要： Disclosed are processes for industrially advantageously producing at a good yield respectively, a hydrogenated aromatic polycarboxylic acid and an acid anhydride thereof each having a high purity. The present invention provides processes for producing a hydrogenated aromatic polycarboxylic acid by (1) hydrogenating an aromatic polycarboxylic acid at a hydrogen partial pressure of 1 MPa or more by a batch system in the presence of a catalyst containing rhodium and palladium in a proportion of 0.5 to 10 parts by weight per 100 parts by weight of the aromatic polycarboxylic acid and by (2) feeding an aromatic polycarboxylic acid to a filling bed of a catalyst containing rhodium and palladium at a WHSV of 1 to 100 h -1 to hydrogenate it at a hydrogen partial pressure of 1 MPa or more by a continuous flow system, and a process for producing a hydrogenated aromatic polycarboxylic anhydride by subjecting the hydrogenated aromatic polycarboxylic acid obtained by the processes described above to dehydration reaction with acetic anhydride of 0.64 to 5.7 times mole based on a carboxyl group of the hydrogenated aromatic polycarboxylic acid.

    摘要翻译： 公开的是用于以良好的产率分别是氢化的芳族多元羧酸工业上有利地制造和酸酐或其每一个都具有高纯度的处理。 本发明提供了用于在含有铑和钯中的0.5的比例的催化剂的存在下，通过间歇式系统在1MPa以上的氢分压产生由（1）芳族多元羧酸的氢化一氢化芳族多元羧酸 至10重量份每100重量份的芳香族多羧酸的和由（2）芳族多元羧酸的进料以1到100小时的WHSV含铑和钯的催化剂的填充床<-1>氢化 它在通过连续流动系统1MPa以上的氢分压，以及用于通过使通过上述脱水反应中与0.64到5.7的乙酸酐的方法获得的氢化的芳族多元羧酸制备氢化的芳族多羧酸酐的方法 倍摩尔基于羧基的氢化的芳族多元羧酸的。

    Adamantanetricarboxylic acid derivatives
    4.
    发明公开
    Adamantanetricarboxylic acid derivatives 审中-公开
    金刚烷三羧酸衍生物

    公开(公告)号：EP1505053A1

    公开(公告)日：2005-02-09

    申请号：EP04101110.7

    申请日：2004-03-18

    申请人： Daicel Chemical Industries, Ltd.

    发明人： Nagano, Shinya ,  Hashimoto, Jiichiro

    IPC分类号： C07C61/125 ,  C07C69/753 ,  C07C233/58 ,  C07C233/60

    CPC分类号： C07C51/60 ,  Y02P20/55 ,  C07C61/135

    摘要： An adamantanetricarboxylic acid derivative is represented by following Formula (1):
    wherein X is a hydrogen atom or a hydrocarbon group; and R 1 , R 2 and R 3 may be the same as or different from one another and are each a carboxyl group which may be protected by a protecting group, or a carbonyl halide group, wherein at least one of R 1 , R 2 and R 3 is a carboxyl group which is protected by a protecting group, or a carbonyl halide group.

    摘要翻译： 金刚烷三羧酸衍生物由下式（1）表示：其中X是氢原子或烃基; R1，R2和R3可以彼此相同或不同，并且各自是可以被保护基团保护的羧基或羰基卤化物基团，其中R1，R2和R3中的至少一个是羧基 被保护基保护的基团或碳酰卤基团。

    Process for producing a hydrogenation product of an aromatic carboxylic acid
    6.
    发明公开
    Process for producing a hydrogenation product of an aromatic carboxylic acid 有权
    一种生产芳族羧酸的氢化产物的方法

    公开(公告)号：EP1219586A2

    公开(公告)日：2002-07-03

    申请号：EP01130038.1

    申请日：2001-12-18

    申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

    发明人： Machida, Hiroshi, Mitsubishi Gas Chemical Co.,Inc. ,  Kedo, Ko, Mitsubishi Gas Chemical Co.,Inc. ,  Zaima, Fumiya, Mitsubishi Gas Chemical Co.,Inc.

    IPC分类号： C07C51/36 ,  C07C61/125 ,  C07C61/12 ,  C07C61/09 ,  C07C62/26 ,  C07C62/28

    CPC分类号： C07C51/36 ,  C07C61/12 ,  C07C61/125 ,  C07C61/09

    摘要： A process for producing a hydrogenation product of aromatic carboxylic acid which comprises continuously producing the hydrogenation product of aromatic carboxylic acid by hydrogenating an aromatic carboxylic acid having a melting point of 250°C or higher in a solvent in the presence of a solid catalyst, wherein the hydrogenation is conducted in a condition such that substantially the entire amount of the aromatic carboxylic acid of a raw material is dissolved in the solvent by recycling a portion of a reaction liquid taken out of a reactor into the reactor.
    An aromatic carboxylic acid having a high melting point and hardly soluble in solvents can be hydrogenated at a suitable reaction temperature in accordance with a continuous process without using a great amount of a solvent and the reaction product of the object compound can be produced very efficiently.

    摘要翻译： 一种生产芳族羧酸，其包括连续地芳族羧酸的氢化具有在固体催化剂的存在下的250℃以上在溶剂中的熔点，worin制备芳香族羧酸的氢化产物的氢化产物的方法 在一个条件搜索做基本上原料的芳香羧酸的总量通过循环取出的反应器到反应器中的反应液的一部分在溶剂中溶解的氢化进行的。 具有在溶剂中的高的熔点和难溶性的芳香族羧酸可以在与连续工艺中雅舞蹈合适的反应温度被氢化，而无需使用溶剂的大量，并且可以非常有效地制造目标化合物的反应产物。

    Psychotropic polycyclic imides
    8.
    发明公开
    Psychotropic polycyclic imides 失效
    精神分析多环氰化物。

    公开(公告)号：EP0286263A1

    公开(公告)日：1988-10-12

    申请号：EP88302499.4

    申请日：1988-03-22

    申请人： AMERICAN HOME PRODUCTS CORPORATION

    发明人： Stack, Gary Paul ,  Golobish, Thomas David ,  Abou-Gharbia, Magid Abdel-Megid

    IPC分类号： C07D401/12 ,  C07D221/24 ,  C07D313/06 ,  C07C61/125 ,  A61K31/45

    CPC分类号： C07C61/125 ,  C07D221/24 ,  C07D313/06 ,  C07D401/12

    摘要： Substituted imides of the following formula are antipsychotic, anxiolytic agents with very little extrapyramidal side effects:
    in which X is -O-, -S-, -SO-, -SO₂-, -CR₃R₄- where R₃ and R₄, independently, are hydrogen, alkyl of 1 to 4 carbon atoms or, taken together with the carbon atom to which they are attached, R₃ and R₄ form a cycloalkyl group of 3 to 5 carbon atoms; n is one of the integers 2, 3, 4 or 5; R is phenyl, alkylphenyl in which the alkyl group contains 1 to 4 carbon atoms, halophenyl, trifluoromethylphenyl, alkoxyphenyl, in which the alkoxy substituent contains 1 to 3 carbon atoms, 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl, halopyrazin-2-yl, 2-pyridinyl, cyanopyridin-2-yl, halopyridin-2-yl, quinolyl, or haloquinolyl; R₁ and R₂, taken together, are alkylene of 3 to 5 carbon atoms or alkenylene of 3 to 5 carbon atoms, or taken with the carbon atoms to which they are attached, R₁ and R₂ complete a benzene ring, or a group of the formula:
    where Y is -CH₂, -CH₂-CH₂-, -O- or -S- and the dotted line represents optional unsaturation; or a pharmaceutically acceptable salt thereof. In addition, the intermediate b3-dicarboxylic and the corresponding anhydrides - 2,3,3a,4,5,6,6a,7,7a-decahydro-­4,6,7-metheno-1 H -cyclopena[a]pentalene-1,3-dicarboxyli­c acid and octahydro-1, 5-methano-6,8,9-metheno-­pentaleno[1,2,-d]oxepin-2,4(1 H , 5 H )-dione represent especially significant aspects of the invention.

    摘要翻译： 下式的取代酰亚胺是具有极少锥体束外副作用的抗精神病药，抗焦虑剂：其中X是-O - ， - S-，-SO-，-SO 2 - ， - CR 3 R 4的，其中R3和R4独立地 是氢，1至4个碳原子的烷基，或与它们所连接的碳原子一起，R3和R4形成3至5个碳原子的环烷基; n是整数2,3,4或5之一; R为苯基，烷基含有1至4个碳原子的烷基苯基，卤代苯基，三氟甲基苯基，烷氧基苯基，其中烷氧基取代基含有1至3个碳原子，2-嘧啶基，卤代嘧啶-2-基，2-吡嗪基，卤代吡嗪 2-吡啶基，2-吡啶基，氰基吡啶-2-基，卤代吡啶-2-基，喹啉基或卤代喹啉基; R 1和R 2一起是3至5个碳原子的亚烷基或3至5个碳原子的亚烯基，或与它们所连接的碳原子一起取代，R 1和R 2完全是苯环，或者式 ：其中Y是-CH 2，-CH 2 -CH 2 - ， - O-或-S-，虚线表示任选的不饱和键; 或其药学上可接受的盐。 此外，中间体b3-二羧酸和相应的酸酐-2,3,3a，4,5,6,6a，7,7a-十氢-4,6,7-元 - 1H-环戊烯并[a] ，3-二羧酸和八氢-1,5-甲基-6,8,9-亚氨基 - 异戊烯[1,2， - ]氧杂七环-2,4（1H，5H） - 二酮代表本发明的特别重要的方面 。

    PROPELLANE DERIVATES AND SYNTHESIS
    10.
    发明公开
    PROPELLANE DERIVATES AND SYNTHESIS 审中-公开
    PROPELLANDERIVATE UND SYNTHESE

    公开(公告)号：EP3114107A1

    公开(公告)日：2017-01-11

    申请号：EP15757721.4

    申请日：2015-03-05

    申请人： Kalyra Pharmaceuticals Inc.

    发明人： BUNKER, Kevin, Duane

    IPC分类号： C07C61/125 ,  C07C235/26 ,  C07C211/19

    摘要： Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).

    摘要翻译： 本文公开了通式（I）的化合物，以及合成取代的双环[1.1.1辛醇]的方法。 本文所述的合成方法使用[1.1.1]推进剂，第VIII族过渡金属化合物，可以贡献取代基的氢化物源和试剂以形成取代的双环[1.1.1]戊烷，例如 通式（I）。