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262 条记录 (耗时 0.027 秒)

    CANNABIDIOL DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    1.
    发明公开
    CANNABIDIOL DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 审中-公开

    公开(公告)号：EP4446306A1

    公开(公告)日：2024-10-16

    申请号：EP22903157.0

    申请日：2022-11-17

    申请人： Deyi Pharmaceutical Ltd.

    发明人： WANG, Shubin ,  DU, Yesong ,  ZHANG, Pingping

    IPC分类号： C07C69/017 ,  C07C271/44 ,  C07C219/04 ,  C07C229/12 ,  A61P1/08 ,  A61K31/05

    摘要： Disclosed in the present invention are a cannabidiol derivative, a preparation method therefor and an application thereof, particularly an application in preventing and treating nervous system diseases (such as Parkinson's disease). The cannabidiol derivative is obtained by screening from a series of synthetic derivatives. An animal testing result shows that the cannabidiol derivative can reduce the balance beam score of a Parkinson's model animal and improve the dopamine level and the tyrosine hydroxylase (TH) cell positive rate in substantia nigra (SubN), can be used for drug development and research of various diseases such as epilepsy and Parkinson's disease, and has better application value.

    PRODUCTION INTERMEDIATE OF POLYMERIZABLE COMPOUND, METHOD FOR PRODUCING SAME, COMPOSITION AND STABILIZATION METHOD
    6.
    发明公开
    PRODUCTION INTERMEDIATE OF POLYMERIZABLE COMPOUND, METHOD FOR PRODUCING SAME, COMPOSITION AND STABILIZATION METHOD 审中-公开

    公开(公告)号：EP3162789A4

    公开(公告)日：2018-01-24

    申请号：EP15814347

    申请日：2015-06-30

    申请人： ZEON CORP

    发明人： OKUYAMA KUMI ,  SAKAMOTO KEI ,  SANUKI KANAKO

    IPC分类号： C07C67/307 ,  C07C67/62 ,  C07C69/017 ,  C07C69/75

    CPC分类号： C07C67/62 ,  C07C67/307 ,  C07C69/017 ,  C07C69/75 ,  C07C2101/14

    摘要： Provided are a production method for compound (II) including reacting compound (I) with a halogenating agent in the presence of at least 0.5 equivalents, relative to compound (I), of a nitrogen atom-containing polar aprotic solvent; a composition containing compound (II), a halogenating agent or the like, and at least 0.5 equivalents, relative to compound (II), of a nitrogen atom-containing polar aprotic solvent; a stabilization method for compound (II); and compound (II). Accordingly, a method for producing compound (II) with high purity in an industrially advantageous manner, a composition in which this production intermediate is stabilized, and a stabilization method for compound (II) are provided. R represents a hydrogen atom or a methyl group, Y 1 and Y 2 each represent a chemical single bond, -O-, -O-C(=O)-, -C(=O)-O-, or the like, G 1 represents a divalent chain aliphatic group having a carbon number of 1-20 or the like, A 1 and A 2 each represent a divalent aromatic hydrocarbon group having a carbon number of 3-12, a divalent alicyclic hydrocarbon group having a carbon number of 3-12, or the like, n represents 0 or 1, and X represents a halogen atom.

    1-(3-4DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF
    7.
    发明公开
    1-(3-4DISUBSTITUTED)PHENYL-2-(3,4-DISUBSTITUTED)PHENYLETHANE COMPOUNDS AND USE THEREOF 审中-公开
    1-（3-4二取代）苯基-2-（3,4-二取代）苯基乙烷化合物及其用途

    公开(公告)号：EP3237366A1

    公开(公告)日：2017-11-01

    申请号：EP15810799.5

    申请日：2015-12-21

    申请人： L'Oréal

    发明人： HITCE, Julien ,  DALKO, Maria ,  FRANTZ, Marie-Céline

    IPC分类号： C07C39/15 ,  A61K8/33 ,  A61Q19/08 ,  C07C69/017 ,  C07C43/205 ,  C07C43/23 ,  C07C49/83 ,  C07C49/84

    CPC分类号： A61K8/347 ,  A61K8/33 ,  A61Q19/08 ,  C07C43/23

    摘要： The present invention relates to the cosmetic use, in a composition containing a physiologically acceptable medium, of at least one compound of formula (I) in which: - R3 means a hydrogen atom or a hydroxyl radical, - R1 and R2 mean, independently of each other, a hydrogen atom, a linear or branched C1-C6 alkyl radical; a benzyl radical; a linear or branched C1-C6 alkylcarbonyl radical not conjugated with the carbonyl; or a linear or branched C1-C6 alkoxycarbonyl radical, and/or of an isomer and/or of a salt and/or of a solvate of said compound of formula (1), for preventing and/or treating the signs of ageing of the skin and its appendages.

    摘要翻译： 本发明涉及在含有生理学上可接受的介质的组合物中的至少一种式（I）化合物的化妆用途，其中：-R 3表示氢原子或羟基，-R 1和R 2表示 彼此独立地为氢原子，直链或支链C 1 -C 6烷基; 苄基; 未与羰基共轭的直链或支链C 1 -C 6烷基羰基; 或直链或支链C 1 -C 6烷氧基羰基和/或所述式（1）化合物的异构体和/或盐和/或溶剂化物用于预防和/或治疗 皮肤及其附属物。

    COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
    8.
    发明公开
    COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE 审中-公开
    具有四个可聚合基团的化合物，液晶组合物和液晶显示装置

    公开(公告)号：EP3199558A1

    公开(公告)日：2017-08-02

    申请号：EP16001435.3

    申请日：2013-04-11

    申请人： JNC Corporation ,  JNC Petrochemical Corporation

    发明人： Gotoh, Yasuyuki ,  Matsukuma, Maiko ,  Yamashita, Junichi

    IPC分类号： C08F20/30 ,  C07C69/54 ,  C09K19/12 ,  C09K19/18 ,  C09K19/20 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/38 ,  G02F1/13 ,  C07C69/80 ,  C09K19/16 ,  C09K19/04 ,  C07C69/007 ,  C09K19/54 ,  C07C69/96 ,  C07C69/017 ,  C07C69/618

    摘要： The subject is to provide a polymerizable compound having a suitable polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition. The subject is to provide a liquid crystal composition having physical properties such as a high maximum temperature of a nematic phase, a low minimum temperature of a nematic phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant, a large specific resistance and a suitable pretilt. The subject is to provide a liquid crystal display device containing the composition and having a wide temperature range in which the device can be used, a short response time, a large voltage holding ratio, a low threshold voltage, a large contrast ratio and a long service life.

    摘要翻译： 本发明的目的在于提供具有适合的聚合反应性，高转化收率和在液晶组合物中的高溶解性的聚合性化合物。 本发明的目的在于提供一种液晶组合物，其具有向列相的上限温度高，向列相的下限温度低，粘度小，适当的光学各向异性，介电常数各向异性大，适当的弹性常数 ，大的比电阻和合适的预倾角。 本发明的课题在于提供一种液晶显示装置，其具有能够使用该装置的温度范围宽，响应时间短，电压保持率高，阈值电压低，对比度大， 使用寿命。