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    PROCESS FOR ISOLATION OF ERGOT ALKALOIDS FROM ERGOT
    1.
    发明公开
    PROCESS FOR ISOLATION OF ERGOT ALKALOIDS FROM ERGOT 有权
    式分离方法麦角生物碱麦角OFF

    公开(公告)号：EP1742953A1

    公开(公告)日：2007-01-17

    申请号：EP05713729.1

    申请日：2005-02-17

    申请人： IVAX PHARMACEUTICALS S.R.O.

    发明人： CVAK, Ladislav ,  HOLAN, Jiri ,  RODER, Lubomir

    IPC分类号： C07D519/02

    CPC分类号： C07D519/02 ,  C07D471/06

    摘要： Ergot alkaloids are isolated from ergot in high yields and purity by a process including extracting Claviceps purpurea, i.e., ergot, with a toluene/ethanol solvent mixture to obtain a primary extract. The primary extract can be further subjected to two steps of liquid-liquid extraction to purify the alkaloids resulting in a purified toluene extract. The toluene extract can be further partially evaporated and a crystalline product obtained by crystallization from the toluene or a mixture of toluene and an aliphatic hydrocarbon.

    Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen
    2.
    发明授权
    Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen 失效
    制备2-BROMO-8-ERGOLINE化合物的方法

    公开(公告)号：EP0141387B1

    公开(公告)日：1989-04-12

    申请号：EP84112913.3

    申请日：1984-10-26

    申请人： SCHERING AKTIENGESELLSCHAFT

    发明人： Börner, Helmut ,  Haffer, Gregor, Dr. ,  Sauer, Gerhard, Dr.

    IPC分类号： C07D457/12 ,  C07D457/06 ,  C07D519/02

    CPC分类号： C07D457/06 ,  C07D457/12 ,  C07D519/02

    摘要： 1. A process for the preparation of 2-bromo-8-ergolinyl compounds of the formula I see diagramm : EP0141387,P4,F4 wherein R**8 is NH2 , NH-CONE2-t , CONH2 , see diagramm : EP0141387,P4,F5 and see diagramm : EP0141387,P5,F1 wherein R**1 is C1-4 -alkyl, and R**2 is C1-4 -alkyl and benzyl, R**9 and R**10 each are hydrogen or together form a bond, and the substituent R**8 may be in the alpha- or beta-position, and the acid additions salts thereof, from corresponding 8-ergolinyl compounds that are unbrominated in the 2-position, and acid addition salts thereof, by bromination, characterised in that the bromination is carried out with elemental bromine in the presence of hydrogen bromide, in a halogenated hydrocarbon as solvent, and, if desired, the acid addition salt is subsequently prepared.

    摘要翻译： 1.制备式I的2-溴-8-高尔胶基化合物的方法，参见图示：EP0141387，P4，F4其中R ** 8是NH2，NH-CONE2-t，CONH2，参见图表：EP0141387，P4 F5，参见图示：EP0141387，P5，F1，其中R ** 1是C 1-4 - 烷基，R ** 2是C 1-4 - 烷基和苄基，R ** 9和R ** 10各自是氢或 一起形成键，并且取代基R ** 8可以在α位或β位，其酸加成盐，来自在2-位未被溴化的相应的8-麦角酰基化合物及其酸加成盐 通过溴化反应，其特征在于溴化反应在溴化氢存在下，在作为溶剂的卤代烃中进行溴化，如果需要，随后制备酸加成盐。