公开(公告)号：EP3416685B1

公开(公告)日：2024-06-26

申请号：EP17708398.7

申请日：2017-02-17

IPC分类号： A61K39/395 ,  C07K16/12 ,  C07K16/28 ,  A61K39/00 ,  A61P1/16 ,  A61P11/00 ,  A61P11/14 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  A61P31/06 ,  A61P31/04 ,  A61P31/08 ,  A61P31/14 ,  A61P31/18 ,  A61P31/16 ,  A61P31/20 ,  A61P31/22 ,  A61P17/00 ,  A61P37/04

CPC分类号： A61K39/395 ,  C07K16/1225 ,  C07K16/28 ,  A61K2039/5420130101 ,  A61K2039/5520130101 ,  A61K2039/5550520130101 ,  A61K2039/62220130101 ,  C07K2317/7020130101 ,  A61K2039/50520130101 ,  C07K2317/7620130101 ,  C07K2317/56520130101 ,  A61K2039/5720130101 ,  A61P1/16 ,  A61P11/00 ,  A61P11/14 ,  A61P17/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/06 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  Y02A50/30 ,  A61K39/099 ,  A61K39/39 ,  A61K2039/5551620130101 ,  A61K39/08 ,  A61K2039/7020130101 ,  A61K2039/54520130101 ,  A61K39/00 ,  A61K39/001119

公开(公告)号：EP4364755A1

公开(公告)日：2024-05-08

申请号：EP22833312.6

申请日：2022-06-30

申请人： The University of Tokyo

发明人： SHINKURA, Reiko ,  MORITA, Naoki ,  TAMANO, Ryutaro

IPC分类号： A61K39/395 ,  A61K9/19 ,  A61P1/04 ,  A61P31/04 ,  C07K16/12 ,  C12N15/13

CPC分类号： A61K9/19 ,  A61K39/395 ,  A61P1/04 ,  A61P31/04 ,  C07K16/00 ,  C07K16/12

摘要： The present invention relates to a composition comprising a monoclonal antibody binding to Clostridium difficile (C. difficile) for inhibiting a growth of Clostridium difficile (C. difficile), and a use thereof. In addition, the present invention discloses the composition for treating an inflammatory bowel disease, and a use thereof.

公开(公告)号：EP4063498B1

公开(公告)日：2024-04-24

申请号：EP21870557.2

申请日：2021-12-03

IPC分类号： C07K16/12 ,  C07K16/40 ,  C12N5/20 ,  G01N33/573

CPC分类号： G01N33/573 ,  C07K16/40 ,  C07K2317/5620130101 ,  C07K2317/56520130101 ,  C07K16/1218

公开(公告)号：EP4063497B1

公开(公告)日：2024-04-24

申请号：EP21870540.8

申请日：2021-12-03

IPC分类号： C12N5/20 ,  C07K16/40 ,  C12N15/13 ,  G01N33/573 ,  G01N33/577 ,  C07K16/12

CPC分类号： G01N33/573 ,  C07K16/40 ,  C07K2317/5620130101 ,  C07K2317/56520130101 ,  C07K16/1228 ,  C07K16/1218

公开(公告)号：EP4342912A2

公开(公告)日：2024-03-27

申请号：EP23214705.8

申请日：2017-09-22

申请人： Merus N.V.

发明人： GEUIJEN, Cecilia Anna Wilhelmina ,  THROSBY, Mark ,  DE KRUIF, Cornelis Adriaan ,  KLOOSTER, Rinse ,  TACKEN, Paulus Johannes ,  LOGTENBERG, Ton

IPC分类号： C07K16/12

摘要： The invention provides means and methods of stimulating activity of a member of the TNF receptor superfamily on a cell. The invention also provides binding molecules such as antibodies that comprises at least two antigen binding sites, wherein a first antigen binding site can bind an extracellular part of said member and a second antigen binding site can bind an extracellular part of a second (different) membrane protein.

公开(公告)号：EP4310099A1

公开(公告)日：2024-01-24

申请号：EP22771559.6

申请日：2022-03-18

申请人： Mie University ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： GABAZZA, Esteban ,  GABAZZA, Corina ,  CANN, Isaac

IPC分类号： C07K16/12 ,  A61K38/10 ,  A61K39/00 ,  A61K39/085 ,  A61K39/395 ,  A61P1/16 ,  A61P7/00 ,  A61P11/00 ,  A61P13/12 ,  A61P37/04 ,  A61P43/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/40 ,  C12N15/13 ,  C12N15/31 ,  C12P21/08 ,  G01N33/53 ,  G01N33/68

摘要： Provided are a monoclonal antibody molecule or a derivative thereof against corisin and a pharmaceutical composition containing the same for ameliorating acute lung injury and acute exacerbation of pulmonary fibrosis. The pharmaceutical composition of the present invention contains a monoclonal antibody molecule or a derivative thereof against corisin, which is a peptide conserved in diverse Staphylococci, such as Staphylococcus nepalensis.

公开(公告)号：EP4283303A3

公开(公告)日：2024-01-24

申请号：EP23198546.6

申请日：2011-07-25

申请人： QIAGEN Australia Holding Pty. Ltd.

发明人： MARIANI, Francesca ,  AMICOSANTE, Massimo ,  COLIZZI, Vittorio ,  SALTINI, Cesare

IPC分类号： A61K38/16 ,  C07K14/35 ,  C07K16/12 ,  C12N5/00 ,  C12Q1/68 ,  G01N33/569 ,  A61K38/10 ,  G01N33/68

摘要： Use of amino acid sequences from Mycobacterium tuberculosis or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom.
The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.

公开(公告)号：EP3549949B1

公开(公告)日：2023-11-29

申请号：EP19167276.5

申请日：2012-04-20

发明人： SIDHU, Maninder K. ,  ANDERSON, Annaliesa, Sybil ,  DONALD, Robert, G., K. ,  JANSEN, Kathrin, Ute ,  KALYAN, Narender, K. ,  MININNI, Terri, L. ,  MORAN, Justin, Keith ,  RUPPEN, Mark, E. ,  FLINT, Michael, James

IPC分类号： C07K14/33 ,  A61K39/08 ,  C07K16/12

公开(公告)号：EP4279923A1

公开(公告)日：2023-11-22

申请号：EP22739499.6

申请日：2022-01-14

申请人： Asahi Kasei Kabushiki Kaisha

发明人： TAKAHASHI, Katsuyoshi ,  ODA, Kotaro ,  SUGATA, Mika

IPC分类号： G01N33/569 ,  C07K16/12 ,  C12N15/13 ,  C12Q1/04 ,  G01N33/543

摘要： Provided is a method that makes it possible to detect the presence and/or amount of bacteria in a food/drink sample, environmental sample, or biological sample in a short period of time, simply, and efficiently. This method comprises a step in which the presences and/or amounts of bacteria of two or more different genera in a sample are simultaneously detected on the basis of antigen-antibody reactions.

公开(公告)号：EP4279503A1

公开(公告)日：2023-11-22

申请号：EP22739501.9

申请日：2022-01-14

申请人： Asahi Kasei Kabushiki Kaisha

发明人： TAKAHASHI, Katsuyoshi ,  ODA, Kotaro ,  SUGATA, Mika

IPC分类号： C07K16/12 ,  C12N15/13 ,  C12Q1/04 ,  C12Q1/06 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569

摘要： Provided is a method that enables the presence and/or amount of bacteria of Enterobacteriaceae in a food/drink sample, an environmental sample, or a biological sample to be detected easily and efficiently in a short amount of time. Said method includes a step for simultaneously detecting, on the basis of an antigen-antibody reaction, the presence and/or amount of bacteria of Enterobacteriaceae of at least two different genera in a sample.