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    Apparatus and method for production of fine particle
    13.
    发明专利
    Apparatus and method for production of fine particle 审中-公开
    用于生产细颗粒的装置和方法

    公开(公告)号：JP2014155915A

    公开(公告)日：2014-08-28

    申请号：JP2013029155

    申请日：2013-02-18

    申请人： Terumo Corp ,  テルモ株式会社

    发明人： HATA MASARU ,  TADA YUICHI

    IPC分类号： B01J2/08 ,  A61J3/02 ,  A61K9/14 ,  A61K9/50 ,  B01J19/00

    摘要： PROBLEM TO BE SOLVED: To provide an apparatus and a method for production of a fine particle which enable immediate acquisition of a fine particle of a specified particle size containing desired ingredients in a sealed system.SOLUTION: A fine particle production apparatus 1 comprises: a centrifuge tube 10; a cartridge 20 which includes a storage chamber 21 for storing a liquid and is inserted into the centrifuge tube 10; a droplet tube 23 provided on a surface of the cartridge 20 inserted into the centrifuge tube 10 which surface is directed to the tip side of the centrifuge tube 10; a discharge outlet 13 for a fine particle S which is provided on the tip side of the centrifuge tube 10; and a lid 43 closing the discharge outlet 13. The cartridge 20 is rotated at a speed corresponding to a centrifugal force G, with the axis of the centrifuge tube 10 as the center, when the centrifugal force G toward the tip direction of the centrifuge tube 10 is applied to the centrifuge tube 10, with the cartridge 20 inserted into the centrifuge tube 10.

    摘要翻译： 要解决的问题：提供能够在密封系统中立即获得含有所需成分的规定粒径的微粒的微粒的制造装置和方法。微粒生产装置1包括： 离心管10; 盒20，其包括用于储存液体并被插入到离心管10中的储存室21; 设置在插入到离心管10中的盒20的表面上的液滴管23，该表面被引导到离心管10的尖端侧; 设置在离心管10的前端侧的细粒S的排出口13; 以及关闭排出口13的盖43.当离心力G离开离心管的顶端方向离心力G时，以与离心力G对应的速度旋转筒20，以离心管10的轴为中心 10被插入到离心管10中，其中盒20插入到离心管10中。

    Method for producing inhaling powder
    14.
    发明专利
    Method for producing inhaling powder 有权

    公开(公告)号：JP2014104068A

    公开(公告)日：2014-06-09

    申请号：JP2012258059

    申请日：2012-11-26

    申请人： Clinipro Co Ltd ,  クリニプロ株式会社

    发明人： ONO SHINICHI

    IPC分类号： A61J3/02 ,  A61K9/14 ,  A61K9/72 ,  A61K31/137 ,  A61K31/167 ,  A61K31/46 ,  A61K31/56 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/26 ,  A61P11/00

    摘要： PROBLEM TO BE SOLVED: To provide a method for producing inhaling powder with excellent dispersivity in which an active ingredient is uniformly distributed.SOLUTION: A method for producing inhaling powder includes: a first mixing step of obtaining a mixture of carriers and a first active ingredient by stirring the first active ingredient and the carriers under the presence of pulverizing media and mixing the first active ingredient with the carriers while pulverizing the first active ingredient; and a second mixing step of adding particulate powder to the mixture obtained in the first mixing step, and performing stirring mixing under the presence of the pulverizing media.

    Apparatus for alternately sifting and blending powder in the same operation
    15.
    发明专利
    Apparatus for alternately sifting and blending powder in the same operation 有权
    用于在相同操作中异步切割和混合粉末的装置

    公开(公告)号：JP2014042912A

    公开(公告)日：2014-03-13

    申请号：JP2013176738

    申请日：2013-08-28

    申请人： R Kalidindi Sanyasi ,  アール カリディンディ サンヤシ

    发明人： SANYASI R KALIDINDI

    IPC分类号： B01F9/02 ,  A61J3/02 ,  B01F3/18 ,  B01F15/00 ,  B07B1/00

    CPC分类号： B01F9/005 ,  B01F3/18 ,  B01F9/04 ,  B01F9/08 ,  B01F13/1041 ,  B01F15/00928 ,  B01F15/00935 ,  B01F2013/108 ,  B07B1/24

    摘要： PROBLEM TO BE SOLVED: To provide a sifting and blending apparatus allowing a screen and a paddle to be easily attached and detached.SOLUTION: A tumbling container (14) is mounted rotatably with a curved screen (20) fixedly mounted within the tumbling container. A multiple vane paddle is mounted on a shaft (26) that is rotatably mounted on the tumbling container. The paddle vanes have angular edges. As the tumbler (14) and the paddle rotate, powder (P) is repeatedly dropped onto the screen to be sifted with the aid of the paddle. Further rotation of the tumbler drops unsifted portions of the powder from the screen to mix with additional powder in the tumbler body. Thus, sifting and blending of the powder is accomplished in mere single operation. The invention utilizes an apparatus having a multiple section screen and a multiple section paddle to enable assembly through the openings provided in the tumbling container.

    摘要翻译： 要解决的问题：提供一种筛网和混合设备，允许筛网和桨叶容易地安装和分离。解决方案：翻转容器（14）可旋转地安装有固定安装在翻滚容器内的弯曲筛网（20）。 多叶片桨安装在可旋转地安装在翻滚容器上的轴（26）上。 桨叶具有角边缘。 当转鼓（14）和桨叶旋转时，粉末（P）被重复地落在筛网上，借助于桨叶筛选。 滚筒的进一步旋转将粉末的未被筛分的部分从筛网中滴下，以便与转筒体中的另外的粉末混合。 因此，粉末的筛选和混合仅在单次操作中完成。 本发明利用具有多部分筛网和多段桨叶的设备，以使得能够通过设置在翻滚容器中的开口进行组装。

    A method of manufacturing of the particles, and particle
    16.
    发明专利
    A method of manufacturing of the particles, and particle 有权

    公开(公告)号：JP5350620B2

    公开(公告)日：2013-11-27

    申请号：JP2007303241

    申请日：2007-11-22

    申请人： キヤノン株式会社 ,  株式会社メドジェル

    发明人： 耕平 渡辺 ,  健 宮崎 ,  泰彦 田畑

    IPC分类号： C08J3/14 ,  A61J3/02 ,  A61K9/14 ,  A61K47/30 ,  A61K49/00 ,  C08L67/04 ,  C08L89/00 ,  H01F1/00

    摘要： PROBLEM TO BE SOLVED: To provide a method for producing particles, capable of producing the particles in simple and easy steps, and to provide, in a high yield, the particles having a homogeneous particle diameter and an excellent dispersibility in a liquid. SOLUTION: The method for producing the particles comprises (1) a step of preparing an aqueous solution containing a polymer, (2) a step of introducing the aqueous solution as droplets into a solvent having a water solubility of 1 mass% or more and less than 50 mass% and (3) a step of preparing the particles containing the polymer in the solvent. In another embodiment, the method for producing the particles comprises (a) a step of preparing an aqueous solution containing a polymer and (b) a step of mixing the aqueous solution into a solvent having a water solubility of 1 mass% or more and less than 50 mass% so that the value calculated by the formula: (mass of water)/(total mass of the solvent and water)×100 does not exceed the solubility of water in the solvent, to prepare the particles containing the polymer. COPYRIGHT: (C)2008,JPO&INPIT

    Method of manufacturing multi-chamber syringe filled with drug
    19.
    发明专利
    Method of manufacturing multi-chamber syringe filled with drug 审中-公开
    制造填充有药物的多室注射器的方法

    公开(公告)号：JP2012245086A

    公开(公告)日：2012-12-13

    申请号：JP2011117766

    申请日：2011-05-26

    申请人： Maeda Sangyo Kk ,  前田産業株式会社

    发明人： SUGITA KOICHI

    IPC分类号： A61J3/02

    摘要： PROBLEM TO BE SOLVED: To provide a means for improving heat conductivity between the shelf of a freeze-drying device and a syringe or lowering the possibility of falling of the syringe in a freeze-drying process for manufacturing a multi-chamber syringe, and to provide a means for preventing movement of a gasket of the multi-chamber syringe in a method of sterilizing the multi-chamber syringe filled with a drug.SOLUTION: A freeze-drying method in the freeze-drying device of an aqueous liquid drug filled in the syringe is a method by fitting a metallic cylindrical support to the lower part of the syringe erected and arranged in the shelf inside the freeze-drying device. In a sterilization method of the multi-chamber syringe of a vial type filled with the drug, when the syringe is subjected to a sterilization process, a rear end side opening of the multi-chamber syringe of the vial type filled with the drug is sealed with a threaded cap or a flip tear-off cap.

    摘要翻译： 要解决的问题：为了提供一种用于提高冷冻干燥装置的搁板与注射器之间的导热性的手段，或降低注射器在用于制造多室注射器的冷冻干燥过程中落下的可能性 并且提供一种用于防止多腔室注射器的垫圈在对填充有药物的多室注射器进行灭菌的方法中的移动的装置。 解决方案：在注射器中填充的水性液体药物的冷冻干燥装置中的冷冻干燥方法是将金属圆柱形支撑件装配到直立并设置在冷冻架内的搁架内的注射器的下部的方法 干燥装置 在填充有药物的小瓶型的多室型注射器的灭菌方法中，当注射器进行灭菌处理时，将填充有药物的小瓶型多室注射器的后端侧开口密封 带有螺纹盖或翻盖式撕开盖。 版权所有（C）2013，JPO＆INPIT