Prodrug of donepezil hydrochloride which is therapeutic agent for alzheimer type dementia
    23.
    发明专利
    Prodrug of donepezil hydrochloride which is therapeutic agent for alzheimer type dementia 审中-公开
    多西他赛氯化氢制剂是阿尔茨海默型DEMENTIA的治疗药物

    公开(公告)号:JP2008280248A

    公开(公告)日:2008-11-20

    申请号:JP2005319382

    申请日:2005-11-02

    CPC分类号: C07D211/22 C07D211/94

    摘要: PROBLEM TO BE SOLVED: To provide a compound expectable of remission and reduction of adverse effects such as vomiting, diarrhea and nightmare rarely observed after administration of donepezil hydrochloride.
    SOLUTION: The compound is represented by the general formula [wherein, R represents an optionally substituted 1-6C alkyl group, a carbamoyl group optionally substituted with one or two 1-6C alkyl groups, an aryloxycarbonyl group optionally substituted with one to three substituents, a 2-6C alkanoyl group optionally substituted with one to three substituents or an optionally substituted arylcarbonyl group; and n represents an integer of 0 or 1] or a pharmaceutically acceptable salt thereof.
    COPYRIGHT: (C)2009,JPO&INPIT

    摘要翻译: 待解决的问题:提供预期能够缓解和减少施用多奈哌齐盐酸盐后很少观察到的不良反应如呕吐,腹泻和噩梦的化合物。 解决方案:该化合物由通式[其中R表示任选取代的1-6C烷基,任选被一个或两个1-6C烷基取代的氨基甲酰基,任选被一个或多个1-6C烷基取代的芳氧基羰基, 三个取代基,任选被一至三个取代基取代的2-6C烷酰基或任选取代的芳基羰基; 和n表示0或1的整数]或其药学上可接受的盐。 版权所有(C)2009,JPO&INPIT