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    Bioactive protein-containing nanoparticle composition and method for producing the same
    55.
    发明专利
    Bioactive protein-containing nanoparticle composition and method for producing the same 审中-公开
    含有生物活性蛋白的纳米材料组合物及其制造方法

    公开(公告)号：JP2009256241A

    公开(公告)日：2009-11-05

    申请号：JP2008107172

    申请日：2008-04-16

    申请人： Galenisearch Laboratories Inc ,  Ltt Bio-Pharma Co Ltd ,  ガレニサーチ株式会社 ,  株式会社Lttバイオファーマ

    发明人： MATSUMOTO TAKESHI

    IPC分类号： A61K47/02 ,  A61K9/14 ,  A61K47/04 ,  A61K47/26

    CPC分类号： A61K33/30 ,  A61K9/51 ,  A61K38/18 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/21 ,  A61K38/27 ,  A61K2300/00

    摘要： PROBLEM TO BE SOLVED: To provide a sustained-release composition that does not cause abnormal response at an administration site and maintains persistent activity of the contained bioactive protein or peptide when a predetermined amount of a bioactive protein or peptide is administered.
    SOLUTION: The bioactive protein-containing nanoparticle composition comprises a bioactive protein or peptide, a water-soluble carbonate, a water-soluble phosphate and a water-soluble zinc salt with one another to form nanoparticle precipitates. The water-soluble zinc salt is added such that the compositional ratio of bioactive protein: the water-soluble zinc salt in a weight ratio is in the range of 1:0.2-1:3.5. The bioactive protein or peptide is G-CSF, hGH, interferon, erythropoietin or midkine.
    COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译： 待解决的问题：提供一种在施用部位不引起异常反应的持续释放组合物，并且当施用预定量的生物活性蛋白质或肽时，保持所含生物活性蛋白质或肽的持久活性。 解决方案：含生物活性蛋白质的纳米颗粒组合物包含生物活性蛋白质或肽，水溶性碳酸盐，水溶性磷酸盐和水溶性锌盐，以形成纳米颗粒沉淀物。 加入水溶性锌盐，使得生物活性蛋白质：水溶性锌盐的重量比的组成比在1:0.2-1:3.5的范围内。 生物活性蛋白或肽是G-CSF，hGH，干扰素，促红细胞生成素或中期因子。 版权所有（C）2010，JPO＆INPIT

    Nanoparticle containing physiologically active protein or peptide, method for producing the same and external preparation comprising the nanoparticle
    60.
    发明专利
    Nanoparticle containing physiologically active protein or peptide, method for producing the same and external preparation comprising the nanoparticle 审中-公开
    含有生理活性蛋白或肽的纳米颗粒，其生产方法和包含纳米颗粒的外部制备

    公开(公告)号：JP2006199589A

    公开(公告)日：2006-08-03

    申请号：JP2003312031

    申请日：2003-09-03

    申请人： Ltt Bio-Pharma Co Ltd ,  株式会社Lttバイオファーマ

    发明人： MIZUSHIMA YUTAKA ,  UENO YUKIO ,  YAMAGUCHI YOKO ,  IGARASHI TOSHISATO ,  SUZUKI JUN ,  ISHIHARA TSUTOMU

    IPC分类号： A61K38/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K9/14 ,  A61K9/51 ,  A61K9/70 ,  A61K9/72 ,  A61K47/02 ,  A61K47/04 ,  A61K47/12 ,  A61K47/16 ,  A61P43/00

    CPC分类号： A61K9/5115 ,  A61K9/5161

    摘要： PROBLEM TO BE SOLVED: To obtain a nanoparticle containing a physiologically active protein or peptide that has excellent absorbability in vivo, exerts high bioavailability and has an effect comparable with that of injection administration by an administration method through the skin or mucosa with regard to a physiologically active protein or peptide.
    SOLUTION: The nanoparticle containing a physiologically active protein or peptide is obtained by making a physiologically active protein or peptide insoluble in water, preparing a primary nanoparticle by using the water-insoluble matter, a medium/long-chain organic compound containing both a hydrophobic group and an anionic residue and a surfactant and bringing the primary nanoparticle into contact successively with a divalent or trivalent metal salt and a divalent or trivalent basic salt. The external preparation comprises the nanoparticle as an active ingredient.
    COPYRIGHT: (C)2006,JPO&NCIPI

    摘要翻译： 待解决的问题：为了获得含有体内吸收性优异的生理活性蛋白质或肽的纳米粒子，通过皮肤或粘膜通过给药方法发挥高生物利用度并具有与注射给药相当的效果， 涉及生理活性蛋白或肽。 解决方案：通过使生理活性蛋白质或肽不溶于水，通过使用水不溶性物质制备初级纳米颗粒，含有两者的中/长链有机化合物来获得含有生理活性蛋白质或肽的纳米颗粒 疏水基团和阴离子残基和表面活性剂，并使初级纳米颗粒依次与二价或三价金属盐和二价或三价碱性盐接触。 外用制剂包含纳米颗粒作为活性成分。 版权所有（C）2006，JPO＆NCIPI