Abstract:
PROBLEM TO BE SOLVED: To prevent cytotoxic effects of amyloid beta protein on cells, to treat a fibrillogenic disease, to decrease oxidation in a biological sample, and to treat diseases or other conditions where free radicals and/or oxidative stress play a role.SOLUTION: This invention relates to use of an indole-3-propionic acid (IPA) or a salt or ester thereof for: preventing the cytotoxic effects of amyloid beta protein on cells; treating the fibrillogenic disease; decreasing the oxidation in a biological sample; and treating the diseases or other conditions where free radicals and/or oxidative stress play a role.
Abstract:
PCT No. PCT/US97/01870 Sec. 371 Date Jul. 31, 1998 Sec. 102(e) Date Jul. 31, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/27764 PCT Pub. Date Aug. 7, 1997A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.