公开(公告)号：JP2010185062A

公开(公告)日：2010-08-26

申请号：JP2009052646

申请日：2009-02-12

申请人： Manami Hirano ,  Toshihisa Hoshiai ,  Lactive Japan:Kk ,  Mitsuhiro Matsumura ,  Akira Mori ,  Susumu Mori ,  Tadatomo Nagao ,  Shoichi Nonaka ,  Toshiro Okuda ,  Ryota Shinohara ,  The Forest:Kk ,  俊郎 奥田 ,  眞奈美 平野 ,  敏久 星合 ,  光洋 松村 ,  株式会社ザ・フォレスト ,  株式会社ラクティブ ジャパン ,  明 毛利 ,  進 毛利 ,  亮太 篠原 ,  正一 野中 ,  忠知 長尾

发明人： MORI SUSUMU ,  NAGAO TADATOMO ,  SHINOHARA RYOTA ,  HOSHIAI TOSHIHISA ,  OKUDA TOSHIRO ,  MORI AKIRA ,  HIRANO MANAMI ,  MATSUMURA MITSUHIRO ,  NONAKA SHOICHI

IPC分类号： C08G63/88 ,  A23L3/3499 ,  A61K8/85 ,  A61K31/765 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12

摘要： PROBLEM TO BE SOLVED: To provide a technique in relation to a low molecular weight lower polylactic acid produced by condensation polymerization and that produced by distillation as a natural raw material, which have no side effect caused by chemical synthetics and chemical agents, and is not accumulated in a human body, and have sustainable functionality of sterilization, a fungicidal, an antimicrobial property, an antifungal property, rot proofness, pH control, and an antioxidation property, which replace environmental hazardous materials. SOLUTION: A method for manufacturing the low molecular weight lower polylactic acid includes: a step (1) to obtain the low molecular weight lower polylactic acid and a lactic acid oligomer via cyclic and ring-opening condensation polymerization by stepwise reducing pressure and raising temperature of a fermentation-L-lactic acid in an inert gas atmosphere, and further dehydrating or raising temperature; and a step (2) to recover cyclic and ring-opening low molecular weight lower polylactic acid separated by dehydration and distilled, wherein dilution of the low molecular weight lower polylactic acid liquid results in: functionality (3) of sterilization, a fungicidal, an antimicrobial property, an antifungal property, rot proofness and the antioxidation property of the undiluted and diluted liquids; a defense reaction (4) of the polylactic acid against viruses; and a working range and concentration (5) of dilution of the condensation polymerization polylactic acid. COPYRIGHT: (C)2010,JPO&INPIT

摘要翻译： 要解决的问题：提供一种通过缩聚产生的低分子量低聚乳酸和通过化学合成和化学试剂不产生副作用的天然原料蒸馏生产的技术， 不会积累在人体内，具有消毒，杀菌，抗菌，抗真菌，防腐，pH控制，抗氧化等功能，具有可替代环保危害物质的可持续功能。 解决方案：低分子量低聚乳酸的制造方法包括：通过逐步减压的循环和开环缩聚获得低分子量低聚乳酸和乳酸低聚物的步骤（1），以及 在惰性气体气氛中升高发酵L-乳酸的温度，进一步脱水或升温; 回收通过脱水分离并蒸馏的循环和开环低分子量低聚乳酸的步骤（2），其中低分子量低聚乳酸液体的稀释导致：灭菌的功能性（3），杀真菌剂， 抗菌性，抗真菌性，防腐性和未稀释和稀释液体的抗氧化性能; 聚乳酸对病毒的防御反应（4） 和缩聚聚乳酸的工作范围和浓度（5）。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2007112751A

公开(公告)日：2007-05-10

申请号：JP2005306138

申请日：2005-10-20

申请人： Mak:Kk ,  Tadatomo Nagao ,  Tokiwa:Kk ,  有限会社Mak ,  株式会社登希和 ,  忠知 長尾

发明人： NAGAO TADATOMO ,  AKIYAMA KENJI

IPC分类号： C07D323/00 ,  A61K8/49 ,  A61K8/72 ,  A61K31/365 ,  A61K31/765 ,  A61P3/10 ,  A61P35/00 ,  A61P37/02 ,  C08G63/78

摘要： PROBLEM TO BE SOLVED: To provide a technique for production by which the content of a cyclic lactic oligomer contained in a cyclopolymerized lactic acid is raised without requiring a complicated apparatus and production process.
SOLUTION: The method for production comprises the following steps. A dehydration condensation step (1) of decompressing and heating up L-lactic acid stepwise in an inert gas atmosphere and thereby obtaining a condensation liquid A having a cyclic type lactic acid oligomer and a chain type lactic acid oligomer formed by dehydration condensation and a lactic acid distillation liquid B comprising mainly the L-lactic acid, a mixing step (2) of mixing the condensation liquid A with the lactic acid distillation liquid B in a prescribed ratio, a cooling step (3) of cooling the resultant mixture C obtained in the mixing step and affording a gel-like substance D, a separation step (4) of adding a solvent dissolving the chain type lactic acid oligomer and L-lactic acid without dissolving the cyclic type lactic acid oligomer to the gel-like substance D, dissolving the substances soluble in the solvent and affording a precipitate E, and a recovering step (5) of recovering the precipitate E and providing a recovered substance G.
COPYRIGHT: (C)2007,JPO&INPIT

摘要翻译： 待解决的问题：提供一种生产技术，其中不需要复杂的装置和制备方法，可以提高环聚乳酸中所含的环状乳酸低聚物的含量。

解决方案：生产方法包括以下步骤。 1.一种在惰性气体气氛中逐步降压L-加氢L-乳酸的脱水缩合工序（1），得到具有环状乳酸低聚物和通过脱水缩合形成的链型乳酸低聚物的凝结液A和乳酸 主要含有L-乳酸的酸性蒸馏液B，以规定比例混合冷凝液A与乳酸蒸馏液B的混合工序（2），将得到的混合物C冷却的冷却工序（3） 混合步骤并提供凝胶状物质D，将不溶解环状乳酸低聚物的溶解链型乳酸低聚物和L-乳酸的溶剂加入到凝胶状物质D中的分离步骤（4） 将可溶于溶剂的物质溶解并提供沉淀物E，以及回收沉淀物E并提供回收物质G的回收步骤（5）。（C）2007，JPO＆INPIT

公开(公告)号：JP2013039117A

公开(公告)日：2013-02-28

申请号：JP2011187952

申请日：2011-08-11

申请人： Makoto Fujiwara ,  誠 藤原 ,  Tadatomo Nagao ,  忠知 長尾 ,  Kazuhisa Kageyama ,  和久 影山

发明人： FUJIWARA MAKOTO ,  NAGAO TADATOMO ,  KAGEYAMA KAZUHISA

IPC分类号： A23L1/30 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K31/357 ,  A61K31/765 ,  A61P1/10 ,  A61P3/10 ,  A61P7/02 ,  A61P9/12 ,  A61P13/08 ,  A61P15/00 ,  A61P17/00 ,  A61P19/02 ,  A61P25/02 ,  A61P29/00 ,  A61P31/14 ,  A61P31/20 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D323/00

摘要： PROBLEM TO BE SOLVED: To provide a functional food which includes cyclic polylactate having activating effect on mitochondria contained in cells at high purity and is easy to orally ingest, in view of problems wherein, while recently cyclic polylactate-containing functional foods are introduced with the expectation that aims and purposes of immune activation, functional recovery of each organ, autonomic adjustment, incretion adjustment, and the like can be satisfied by a single product, the cyclic polylactate has strong acid and bitter tastes giving strains in oral intake and making it desirable to mold the cyclic polylactate into a tablet shape, but tableting it is hard without addition of additives since the cyclic polylactate has high moisture absorbency, and the polylactate content tends to become low.SOLUTION: According to polymerization distribution analyses of the cyclic polylactate, 5% or more of cyclic chain-like polylactate out of the cyclic polylactate is contained while excepting the distribution quantity of a low-polymerization degree range with polymerization degrees of 2 to 3, whereby tableting can be attained at a minimum additive ratio, and a functional food which includes the cyclic polylactate having activating effect on mitochondria at high purity while reducing strains such as bitter and acid tastes in oral intake can be provided.

摘要翻译： 待解决的问题：为了提供功能性食品，其包括对高纯度细胞中含有的线粒体具有活化作用的环状聚乳酸，并且容易口服摄取的功能性食品，其中，尽管最近环状含乳酸的功能性食品是 引入了期望，单一产品可以满足免疫激活的目的和目的，每个器官的功能恢复，自主调整，增加调整等，环状聚乳酸具有强酸和苦味，口服摄取菌株， 需要将环状聚乳酸酯成型为片状，但由于环状聚乳酸酯具有高吸湿性，而且乳酸酯含量倾向于变低，所以不添加添加剂而进行压片是困难的。 解决方案：根据环状聚乳酸的聚合分布分析，除了聚合度为2〜10的低聚合度范围的分布量外，还含有环状聚乳酸酯中的5重量％以上的环状链状聚乳酸酯 3，其中可以以最小添加比例进行压片，并且可以提供包括具有高纯度线粒体活化作用的环状聚乳酸的功能性食品，同时减少口服摄入中的苦味和酸味等菌株。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2009293001A

公开(公告)日：2009-12-17

申请号：JP2008167899

申请日：2008-06-02

申请人： Dyuboisu:Kk ,  Manami Hirano ,  Shuji Kawamoto ,  Lactive Japan:Kk ,  Mitsuhiro Matsumura ,  Tadatomo Nagao ,  Shoichi Nonaka ,  修司 川本 ,  眞奈美 平野 ,  有限会社デュボイス ,  光洋 松村 ,  株式会社ラクティブ ジャパン ,  正一 野中 ,  忠知 長尾

发明人： NAGAO TADATOMO ,  HIRANO MANAMI ,  MATSUMURA MITSUHIRO ,  KAWAMOTO SHUJI ,  NONAKA SHOICHI

IPC分类号： C09B67/44 ,  A23K1/16 ,  A23L1/275 ,  A23L2/58 ,  A61K8/97 ,  C07C67/08 ,  C07C69/68 ,  C09B67/04 ,  C09B67/54

摘要： PROBLEM TO BE SOLVED: To provide a technique enhancing safety as food by extracting a plant dye essence by an extraction method using a dehydration-concentrated lactic acid in place of ethanol. SOLUTION: The technique includes a dehydration-concentrating step (1) of obtaining an extract of plant dyes using, as an extraction solvent, a concentrated liquid having a dehydration-concentrated lactic acid and its oligomer by heating up L-lactic acid under reduced pressure gradually in an inert gas atmosphere, a mixing and extracting step (2) of mixing a plant with the dehydration-concentrated liquid, a separation step (3) of separating an extraction liquid obtained in the mixing and extracting step from a residue, an extraction liquid recovery step (4) of obtaining a supernatant liquid obtained by removing a precipitate of a dye extraction liquid obtained in the separation step, an extraction liquid powderizing step (5) of neutralizing the dye extraction liquid and obtaining a powder by freeze-drying, and a separated residue neutralization treatment (6) of neutralizing the separated residue by a sieve and allowing it to be reutilized. COPYRIGHT: (C)2010,JPO&INPIT

摘要翻译： 要解决的问题：通过使用脱水浓缩的乳酸代替乙醇的提取方法提取植物染料精华来提供提高作为食物的安全性的技术。 解决方案：该技术包括脱水浓缩步骤（1），其通过加热L-乳酸作为萃取溶剂获得具有脱水浓缩乳酸及其低聚物的浓缩液的植物染料提取物 在惰性气体气氛中逐渐减压，将植物与脱水浓缩液体混合的混合萃取步骤（2），将从混合萃取步骤得到的萃取液从残渣中分离的分离步骤（3） 萃取液回收步骤（4），获得通过除去在分离步骤中得到的染料提取液的沉淀而获得的上清液;中和染料提取液的提取液粉末化步骤（5），并通过冷冻获得粉末 和分离的残留物中和处理（6），通过筛子中和分离的残余物并使其再利用。 版权所有（C）2010，JPO＆INPIT