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公开(公告)号：JP2011010616A
公开(公告)日：2011-01-20
申请号：JP2009158838
申请日：2009-07-03
IPC分类号： C12M3/06
CPC分类号： C12M47/04
摘要： PROBLEM TO BE SOLVED: To smoothly perform the treatment of an adipose tissue by sufficiently discharging only tumescent liquid.SOLUTION: This container 1 for treating the adipose tissue includes a container body 2 housing the adipose tissue A sucked out from a body and tumescent liquid B and having a discharging port 2b opening up at a bottom surface 2a, piping 4 connected with the discharging port 2b and discharging fluid from the inside of the container body 2, a filter 3 covering the discharging port 2b in the container body 2 and having a hole having a smaller diameter dimension than that of the adipose tissue A, detecting parts 5a, 5b for detecting transmittance at the inside of the piping 4 in the vicinity of the discharging port 2b, and a controlling part 7 stopping the discharge from the discharging port 2b based on the change of the transmittance detected by the detecting parts 5a, 5b during the discharge of the fluid.
摘要翻译： 要解决的问题：通过仅使肿胀液体充分排出，平稳地进行脂肪组织的处理。解决方案：用于处理脂肪组织的容器1包括容纳从身体吸出的脂肪组织A的容器体2和液体B 并且具有在底面2a开口的排出口2b，与排出口2b连接并从容器主体2的内部排出流体的管道4，覆盖容器主体2中的排放口2b的过滤器3， 具有比脂肪组织A小的直径尺寸的孔，以及用于检测在排出口2b附近的管道4内部的透射率的检测部分5a，5b，以及停止从排出口排出的控制部分 2b基于在流体排出期间由检测部分5a，5b检测到的透射率的变化。
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2.发明专利
公开(公告)号：JP2010095531A
公开(公告)日：2010-04-30
申请号：JP2010001420
申请日：2010-01-06
发明人： FRASER JOHN , HENDRICK MARC H
IPC分类号： A61K35/28 , A61M1/00 , A61K31/436 , A61K35/02 , A61K35/12 , A61K35/34 , A61K35/36 , A61K38/00 , A61K38/16 , A61K45/00 , A61L27/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P37/06 , C12M3/06 , C12N5/0775
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： PROBLEM TO BE SOLVED: To treat patients with cells present in a processed lipoaspirate tissue.
SOLUTION: A method for treating patients includes a delivery process of a concentrated amount of stem cells obtained from processed adipose tissue. The method can be performed in a closed system, thus no stem cell is exposed to the exterior environment before administration to the patient. The composition administered to the patient includes a mixture of the adipose tissue and the stem cells, and includes higher concentration of stem cells than when the adipose tissue was removed from the patient.
COPYRIGHT: (C)2010,JPO&INPIT摘要翻译： 要解决的问题：治疗患有加工脂溢性组织中存在的细胞的患者。 解决方案：治疗患者的方法包括从加工的脂肪组织获得的浓缩量的干细胞的递送过程。 该方法可以在封闭系统中进行，因此在施用给患者之前没有干细胞暴露于外部环境。 施用于患者的组合物包括脂肪组织和干细胞的混合物，并且包括比从患者中除去脂肪组织时更高浓度的干细胞。 版权所有（C）2010，JPO＆INPIT
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3.发明专利System and method for separating and concentrating regenerative cell from tissue 有权用于从组织分离和浓缩再生细胞的系统和方法
公开(公告)号：JP2012075439A
公开(公告)日：2012-04-19
申请号：JP2011217918
申请日：2011-09-30
IPC分类号： C12M1/00 , A61L27/00 , C12M3/06 , C12M3/08 , C12N20060101 , C12N5/00 , C12N5/0775
CPC分类号： B04B5/0442 , A61K35/28 , B04B5/0407 , B04B2005/0471 , C12M33/14 , C12M45/00
摘要： PROBLEM TO BE SOLVED: To provide systems and methods for separating, for example, regenerative cells from a wide variety of tissues and concentrating the regenerative cells.SOLUTION: There are provided systems and methods that are used to separate cells from a wide variety of tissues. In particular, there are described automated systems and methods that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 要解决的问题：提供用于分离例如来自各种组织的再生细胞并集中再生细胞的系统和方法。 解决方案：提供了用于从多种组织分离细胞的系统和方法。 特别地，描述了将再生细胞例如干细胞和/或祖细胞从脂肪组织分离的自动化系统和方法。 该系统和方法提供了快速和可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2010127708A
公开(公告)日：2010-06-10
申请号：JP2008301310
申请日：2008-11-26
发明人： SHIBA YOSHIAKI , KINOSHITA AKI , KARASAWA CHISATO , TSUCHIDA HIRONORI , DOUGLAS M ARM , LUCAS V FORNACE
摘要： PROBLEM TO BE SOLVED: To surely separate a group of to-be-separated cells without attaching the to-be-separated cells to a fat content. SOLUTION: A centrifugal separation vessel 1 comprises: a cylindrical vessel body 2 for accommodating a cell suspension, and rotated so as to cause the bottom 2b to be radially and outwardly oriented; a liquid pipeline 6 for supplying and discharging liquids C, E to/from the vessel body 2; and an accommodation section 3 communicating with a space within the vessel body 2 in the vicinity of an end 2a opposite to the bottom 2b of the vessel body 2, and accommodating a fluid F overflowing the vessel body 2. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 要解决的问题：为了确定地分离一组待分离的细胞，而不将待分离的细胞附着到脂肪含量。 解决方案：离心分离容器1包括：用于容纳电池悬架的圆筒形容器主体2，并且旋转以使底部2b径向向外定向; 用于向容器主体2供应液体C，E的液体管道6; 以及与容器主体2的与底部2b相对的端部2a附近的容器主体2内的空间连通并容纳溢流于容器主体2的流体F的容纳部3。 ）2010，JPO＆INPIT
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公开(公告)号：JP2010075066A
公开(公告)日：2010-04-08
申请号：JP2008244403
申请日：2008-09-24
CPC分类号： B04B5/0421 , B01L3/5021 , B01L99/00 , B01L2300/046 , B01L2400/0487 , B04B15/12 , C12M33/10 , C12M47/04
摘要： PROBLEM TO BE SOLVED: To provide a centrifugal separation container for recovering a suspension of cells which contains a cell population from which unnecessary components have been removed by efficiently cleaning the cell population.
SOLUTION: The centrifugal separation container 1 is provided with a tubular container body 2 for containing the suspension of cells and rotated with a bottom section 2a directed outward radially, a supernatant suction pipe 4 having a first opening 4a which is located in the container body 2 at a position in the middle in the depth direction of the container body and sucking a supernatant obtained by centrifugally separating the suspension of cells in the radial direction of the container body 2, and a cleaning liquid discharge pipe 3 having a second opening 3a which is located in the container body 2 at a position in the middle in the depth direction of the container body; and axially discharging a cleaning liquid toward the bottom section 2a of the container body 2, and the supernatant suction pipe 4.
COPYRIGHT: (C)2010,JPO&INPIT摘要翻译： 解决问题的方案：提供一种用于回收细胞悬浮液的离心分离容器，该容器含有通过有效清洗细胞群而从中除去不需要的成分的细胞群。 解决方案：离心分离容器1设置有管状容器主体2，用于容纳电池的悬浮液，并且以径向向外指向的底部部分2a旋转，上游吸入管4具有位于第二开口4a中的第一开口4a 容器主体2在容器主体的深度方向的中间位置吸取通过在容器主体2的径向离心分离电池的悬浮液而获得的上清液，以及具有第二开口的清洗液排出管3 3a，其在容器主体2的深度方向中间的位置处位于容器主体2中; 并且朝向容器主体2的底部2a和上清液吸管4轴向地排出清洗液。版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2010127620A
公开(公告)日：2010-06-10
申请号：JP2008299050
申请日：2008-11-25
发明人： HARA MITSUHIRO , DOUGLAS M ARM , LUCAS V FORNACE
IPC分类号： G01N1/10
摘要： PROBLEM TO BE SOLVED: To easily and automatically acquire a necessary amount of cell suspension. SOLUTION: The apparatus 1 for treating biological tissue is provided with: a decomposition treating part 2 decomposing a biological tissue and acquiring cell suspension containing cells derived from the living body; a cell separating part 4 separating the cell suspension acquired with the decomposition treating part 2 into the cells derived from the living body and supernatant by receiving it in a centrifuge vessel and centrifugally treating it; a supernatant removing means 5 removing the supernatant from the centrifuge vessel until the residual amount reaches the predetermined amount; a dilution liquid amount setting part 6 setting the amount of the dilution liquid which is supplied to the cells derived from the living body, obtained by removing the supernatant with the supernatant removing means 5; and a suspension generating means 7 generating the cell suspension by supplying a predetermined amount of the dilution liquid, set with the dilution liquid amount setting part 6, into the centrifuge vessel. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 要解决的问题：为了容易和自动地获得必需量的细胞悬浮液。 解决方案：用于处理生物组织的装置1具有：分解处理部分2，分解生物组织并获取含有源自活体的细胞的细胞悬浮液; 将通过分解处理部2取得的细胞悬浮液分离成来自活体的细胞的细胞分离部4和上清液，将其离心收集并离心处理; 上清液去除装置5，从离心容器中除去上清液，直到剩余量达到预定量; 稀释液量设定部6，其设定通过用上清液除去机构5除去上清液而获得的来自生物体的细胞的稀释液量; 以及悬浮产生装置7，通过将设置有稀释液量设定部6的预定量的稀释液供给到离心机容器中而产生细胞悬浮液。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2010075114A
公开(公告)日：2010-04-08
申请号：JP2008248526
申请日：2008-09-26
发明人： TAMURA TOMOAKI , OGAWA YUJI , DOUGLAS M ARM , ROBERT K SHANAHAN , PETERSON ALVIN
CPC分类号： C12M47/04
摘要： PROBLEM TO BE SOLVED: To provide a living tissue treating apparatus and a living tissue treating method capable of efficiently destructing and removing erythrocyte from a living tissue. SOLUTION: The living tissue treating apparatus 1 is provided with a cleaning vessel 2 holding the living tissue A and a cleaning liquid B, a circulation path 3 placed out of the cleaning vessel 2 and returning the cleaning liquid B discharged from the cleaning vessel 2 again to the cleaning vessel 2, and an activated carbon filter 4 placed in the middle of the circulation path 3 and holding an activated carbon 5 to contact with the cleaning liquid B. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 解决问题的方案：提供能够有效地从活体组织中去除和除去红细胞的活组织处理装置和活组织处理方法。 解决方案：活体组织处理装置1设置有保持生物体组织A的清洁容器2和清洁液B，从清洁容器2排出的循环路径3，并使从清洗出来的清洗液B返回 容器2再次提供到清洁容器2，以及放置在循环路径3的中间并保持活性炭5与清洁液体B接触的活性炭过滤器4.版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2010043876A
公开(公告)日：2010-02-25
申请号：JP2008206398
申请日：2008-08-08
IPC分类号： G01N1/10
摘要： PROBLEM TO BE SOLVED: To aseptically take out a separated cell layer to the outside without mixing contamination such as dust with the separated cell layer by a simple configuration. SOLUTION: A centrifugal separation container 1 is configured to store a cell suspension and to allow centrifugal force to act on the cell suspension to separate the cell suspension into the cell layer and supernatant fluid and equipped with a cylindrical container body 2 closed at one end in its axial direction and having the opening 2a at its other end, a lid member 3 for closing the opening 2a of the container body 2 and the suction pipe 4b which extends toward the closed end 2e of the container body 2 from the lid member 3 and of which the suction port 4a is arranged in the vicinity of the closed end 2e. The contact part 7 brought into close contact with the inner surface of the closed end 2e and comprising an elastic material is provided to the leading end of the suction pipe 4b. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 要解决的问题：通过简单的构造，无菌地将分离的电池层取出到外部，而不会与分离的电池层混合诸如灰尘的污染物。 解决方案：离心分离容器1构造成存储细胞悬浮液并允许离心力作用于细胞悬浮液以将细胞悬浮液分离成细胞层和上清液，并配备有封闭的圆柱形容器体2 其一端在其轴向并且在其另一端具有开口2a，用于封闭容器主体2的开口2a的盖构件3和从盖子朝向容器主体2的封闭端2e延伸的吸入管4b 构件3，其吸入口4a布置在封闭端2e附近。 与封闭端部2e的内表面紧密接触并且包括弹性材料的接触部分7设置在吸入管4b的前端。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2009269930A
公开(公告)日：2009-11-19
申请号：JP2009189198
申请日：2009-08-18
发明人： FRASER JOHN K , HEDRICK MARC H
CPC分类号： A01N1/0284 , A01N1/02 , A01N1/0221
摘要： PROBLEM TO BE SOLVED: To provide extraction of adipose tissues, separation of desired components from the adipose tissues, and subsequent storage of cell populations derived from adipose tissues containing materials within a range of the first two building blocks.
SOLUTION: The method of recovering stem cells, etc., from adipose tissues and preserving them comprises a step of treating adipose tissues evacuated in a cell collection portion which has been isolated from a container via a permeable membrane, in which the permeable membrane is used for allowing a component that can be disposed off to pass therethrough while holding the materials containing the desired components from the adipose tissues in the cell collection portion; a step of separating the materials held in the cell collection portion from the component that can be disposed off, and separating at least one of a matrix substance and adipose cell-depleted cell populations from the materials; and a step of performing cryopreservation and low temperature preservation of one or more of the adipose cell-depleted cell populations and the matrix substance.
COPYRIGHT: (C)2010,JPO&INPIT摘要翻译： 要解决的问题：提供脂肪组织的提取，从脂肪组织分离所需组分，以及随后储存源自含有前两个结构单元范围内的材料的脂肪组织的细胞群。 解决方案：从脂肪组织回收干细胞等的方法并保存它们包括处理通过可渗透膜从容器中分离的细胞收集部分中抽真空的脂肪组织的步骤，其中可渗透的 膜用于允许可以排出的组分通过，同时将含有所需组分的材料从细胞收集部分中的脂肪组织保持; 将保持在细胞收集部分中的材料与可以处置的成分分离，并从基质分离基质物质和脂肪细胞贫化细胞群中的至少一种; 以及对一种或多种脂肪细胞贫化细胞群体和基质物质进行低温保存和低温保存的步骤。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2008278822A
公开(公告)日：2008-11-20
申请号：JP2007126968
申请日：2007-05-11
发明人： TSUCHIDA HIRONORI
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2430/40 , C12M45/09 , C12N2509/00
摘要： PROBLEM TO BE SOLVED: To degrade a biotissue in a short time and obtain cells in high yield without lowering the healthiness of the cell obtained by degradation. SOLUTION: The method for degrading a biotissue comprising the treatment of the biotissue with a digestive enzyme is provided with a degradation starting step S32 to immerse the biotissue in a digestive liquid obtained by mixing a digestive enzyme in a solvent to start the degradation of the biotissue, and an enzyme concentration lowering step S31 to lower the concentration of the digestive enzyme in the digestive liquid at a prescribed time after the start of degradation. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译： 待解决的问题：在短时间内降解生物组织并以高产率获得细胞而不降低通过降解获得的细胞的健康。 提供了包括用消化酶处理生物组织的降解生物组织的方法，其具有降解开始步骤S32，以将生物组织浸入通过将消化酶混合在溶剂中而获得的消化液中以开始降解 的酶浓度降低步骤S31，以在降解开始后的规定时间降低消化液中的消化酶的浓度。 版权所有（C）2009，JPO＆INPIT
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