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11 条记录 (耗时 0.028 秒)

    Method of cell therapy for treatment of tumor
    2.
    发明专利
    Method of cell therapy for treatment of tumor 审中-公开
    细胞治疗肿瘤治疗方法

    公开(公告)号：JP2010235611A

    公开(公告)日：2010-10-21

    申请号：JP2010108798

    申请日：2010-05-10

    申请人： Ortho Mcneil Pharmaceut Inc ,  オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド

    发明人： LETURCQ DIDIER J ,  MORIARTY ANN M ,  JACKSON MICHAEL R ,  PETERSON PER A ,  RICHARDS JON M

    IPC分类号： A61K35/14 ,  A61K38/21 ,  A61P35/00 ,  A61P43/00 ,  C07K7/06

    摘要： PROBLEM TO BE SOLVED: To provide a method of cell therapy for the treatment of tumor, especially the treatment of metastatic melanoma. SOLUTION: This method of cell therapy of a test subject comprises: steps of administration of an effective amount of interferon-α enhancing the expression of a tumor antigen on the surface of tumor to the test subject accompanying melanoma; and inoculation of an effective amount of own cytotoxic T lymphocyte having specificity to the melanoma-related target antigen to the test subject. A method of obtaining the cytotoxic T lymphocyte is also disclosed. COPYRIGHT: (C)2011,JPO&INPIT

    摘要翻译： 要解决的问题：提供用于治疗肿瘤的细胞疗法的方法，特别是治疗转移性黑素瘤。 解决方案：该测试对象的细胞治疗方法包括以下步骤：将有效量的干扰素-α施用于肿瘤表面上的肿瘤抗原表达与伴随黑素瘤的测试对象的步骤; 以及将有效量的对黑色素瘤相关的靶抗原具有特异性的本身的细胞毒性T淋巴细胞接种到测试对象。 还公开了获得细胞毒性T淋巴细胞的方法。 版权所有（C）2011，JPO＆INPIT

    Cell therapy method for treating tumor
    4.
    发明专利
    Cell therapy method for treating tumor 审中-公开
    细胞治疗方法治疗肿瘤

    公开(公告)号：JP2005139118A

    公开(公告)日：2005-06-02

    申请号：JP2003377653

    申请日：2003-11-07

    申请人： Ortho Mcneil Pharmaceut Inc ,  オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド

    发明人： LETURCQ DIDIER J ,  MORIARTY ANN M ,  JACKSON MICHAEL R ,  PETERSON PER A ,  RICHARDS JON M

    IPC分类号： A61K38/00 ,  A61K38/21 ,  A61P31/12 ,  A61P35/00

    摘要： PROBLEM TO BE SOLVED: To provide a method for isolating, stimulating and expanding a naive cytotoxic T lymphocyte precursor cell (CTLp) to an antigen-specific effector capable of lysing a tumor cell in vivo, to solve the problem wherein T cell response is often diminished in human with a compromised immune system. SOLUTION: The present ex vivo protocol produces a fully functional effector. Artificial antigen presenting cells (AAPCs; Drosophila melanogaster) transfected with human HLA class I and defined accessory molecules, are used to stimulate CD8 + T cells from normal donors and cancer patients. The class I molecules expressed to a high density on the surface of the Drosophila cells are empty, enabling efficient loading of multiple peptides that results in the generation of polyclonal responses recognizing tumor cells endogenously expressing specific peptides. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：为了提供一种将天然细胞毒性T淋巴细胞前体细胞（CTLp）分离，刺激和扩增到能够在体内裂解肿瘤细胞的抗原特异性效应物的方法，以解决其中T细胞 免疫系统受损的人群的反应往往减少。 解决方案：本离体方案产生完全功能的效应物。 用人类HLA I类和定义的辅助分子转染的人造抗原呈递细胞（AAPCs;果蝇）被用于刺激正常供体和癌症患者的CD8 + SP细胞。 在果蝇细胞表面高密度表达的I类分子是空的，能够有效地加载多个肽，从而产生识别内源表达特异性肽的肿瘤细胞的多克隆应答。 版权所有（C）2005，JPO＆NCIPI

    5-((HETERO ARYL)ALKYL)-3-OXO-PYRIDO(1,2-A)BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVE
    5.
    发明专利
    5-((HETERO ARYL)ALKYL)-3-OXO-PYRIDO(1,2-A)BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVE 失效

    公开(公告)号：JPH11100380A

    公开(公告)日：1999-04-13

    申请号：JP19648598

    申请日：1998-06-29

    申请人： ORTHO MCNEIL PHARMACEUT INC

    发明人： REITZ ALLEN B ,  FITZPATRICK LOUIS J ,  JORDAN ALFONZO D ,  SANFILIPPO PAULINE J

    IPC分类号： A61K31/435 ,  A61P25/00 ,  C07D471/04

    摘要： PROBLEM TO BE SOLVED: To obtain a new compound, which is a ligand relating benzodiazepine binding portion on γ-aminobutyric acid-A receptor, and useful for treatment of central nerve hindrance or as muscle relaxant or the like. SOLUTION: This new compound is represented by formula I X is H, a 1-8C alkyl, a halogen, a perfluoro(1-8C alkyl) or the like; R is a (CH2 )n hetero cycle [(n) is 1-4], a halogen, a perfluoro(lower) alkyl or the like; Ar is a (substituted) phenyl, a (substituted) heterocycle}, e.g. 7-fluoro-1,2-dihydro-5-[2-(3- thienyl)ethyl]-3-oxo-N-(2-fluorophenyl)pyrido[1,2-a]benzimidazole-4-ca rboxamide. The compound is obtained by treating pyridobenzimidazole derivative of formula II with heterocyclic alkanol such as 2-furanylmethanol, an activating agent such as diethyl azodicarboxylate, and triphenylphosphine in a solvent such as benzene at about 0 deg.C to a room temperature for about 1-24 hr.

    TABLET DISPENSER OF VARIABLE STARTING DAY TYPE
    9.
    发明专利
    TABLET DISPENSER OF VARIABLE STARTING DAY TYPE 失效

    公开(公告)号：JPH11313873A

    公开(公告)日：1999-11-16

    申请号：JP6679799

    申请日：1999-03-12

    申请人： ORTHO MCNEIL PHARMACEUT INC

    发明人： LAMBELET JR LAWRENCE E

    IPC分类号： A61J7/00 ,  A61J1/03 ,  A61J7/04 ,  B65D83/04

    摘要： PROBLEM TO BE SOLVED: To enable an easy filling of tablets in a tablet dispenser with a circular one-way knob having a periodic display by constructing it such chat the knob is surrounded by a skirt with a plurality of notches arranged at equal intervals. SOLUTION: This dispenser 1 is provided with a circular knob 3, which is surrounded by a skirt 9 with a plurality of notches 11 being arranged at equal intervals and being capable of rotating in one direction, is mounted on a base 5 with a flat support 6 with a tablet dispensing opening and a rising wall 8 at its circumference. Namely the knob 3 is mounted around a rotation center means 7 by a combining means, and the means 3 is formed with a sharp tip projection 17, an indicator 15 for an optimum indication, a present time or initial time tablet position 97 and a tablet application day 12 on a flat surface 2 of the rotatable knob 3. Further, this dispenser 1 is provided with a tablet wrapping means 19 having a plurality of tablet pockets 21.