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    Inhibitor of 8-hydroxydeoxyguanosine formation
    1.
    发明专利
    Inhibitor of 8-hydroxydeoxyguanosine formation 审中-公开
    8-羟基己酸形成抑制剂

    公开(公告)号：JP2009263243A

    公开(公告)日：2009-11-12

    申请号：JP2008111237

    申请日：2008-04-22

    申请人： Tama Seikagaku Kk ,  タマ生化学株式会社

    发明人： HATAKE SHUICHI ,  IWAMA TORU

    IPC分类号： A61K31/351 ,  A61K8/35 ,  A61K36/00 ,  A61K36/48 ,  A61P17/16 ,  A61P39/00 ,  A61Q17/04

    摘要： PROBLEM TO BE SOLVED: To find a substance for effectively suppressing formation of 8-hydroxydeoxyguanosine (8-OHdG) pointed out to be a risk factor in atheromatous arteriosclerosis and diabetes. SOLUTION: Asparatine is confirmed to have 8-OHdG formation inhibitory action among components contained in a non-fermentation type rooibos. Asparatine is confirmed to protect skin tissue cells from a stress such as especially an ultraviolet light. COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译： 要解决的问题：找到有效抑制8-羟基脱氧鸟苷（8-OHdG）形成的物质，指出是动脉粥样硬化性动脉硬化和糖尿病的危险因素。 解决方案：天冬氨酸被证实在非发酵型乳制品中包含的成分中具有8-OHdG形成抑制作用。 天冬氨酸被证实可以保护皮肤组织细胞免受诸如特别是紫外线的胁迫。 版权所有（C）2010，JPO＆INPIT

    Method for producing geranyl geraniol
    2.
    发明专利
    Method for producing geranyl geraniol 审中-公开
    生产GERANYL GERANIOL的方法

    公开(公告)号：JP2007238508A

    公开(公告)日：2007-09-20

    申请号：JP2006063677

    申请日：2006-03-09

    申请人： Tama Seikagaku Kk ,  タマ生化学株式会社

    发明人： NARA TETSUO ,  IWAMA TORU ,  NAKATATE MASAO

    IPC分类号： C07C29/76 ,  C07C29/88 ,  C07C33/02

    摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing high purity geranyl geraniol which is a raw material of an intermediate for various useful materials, especially pharmaceuticals.
    SOLUTION: The method for producing high purity geranyl geraniol is to remove acidic components from crude geranyl geraniol prepared by extracting annatto (Bixa Orellana) seeds or its oily residue of pigment extraction, subsequently react the resultant product with a dibasic acid anhydride in a nonpolar solvent to bring the same to a hemi-esterified compound of geranyl geraniol and purify the semi-esterified compound by adsorbing with an anion exchange resin.
    COPYRIGHT: (C)2007,JPO&INPIT

    摘要翻译： 待解决的问题：提供一种有效生产作为各种有用材料，特别是药物的中间体的原料的高纯度香叶基香叶醇的方法。 解决方案：生产高纯度香叶基香叶醇的方法是通过提取胭脂树（Bixa Orellana）种子或其油性油墨残留物将颜料提取物中的酸性成分从粗制香叶香叶醇中除去，然后将得到的产物与二元酸酐反应 非极性溶剂使其与半酯化的香叶基香叶醇化合物一起，并用阴离子交换树脂吸附来净化半酯化的化合物。 版权所有（C）2007，JPO＆INPIT

    Water-dispersion type preparation containing plant sterol
    4.
    发明专利
    Water-dispersion type preparation containing plant sterol 审中-公开
    含有植物甾体的水分散型制剂

    公开(公告)号：JP2005143317A

    公开(公告)日：2005-06-09

    申请号：JP2003381502

    申请日：2003-11-11

    申请人： Tama Seikagaku Kk ,  タマ生化学株式会社

    发明人： FURUKAWA MITSUGI

    IPC分类号： A23L2/52 ,  A23L1/30 ,  A61K9/10 ,  A61K31/575 ,  A61K47/14 ,  A61P3/06

    摘要： PROBLEM TO BE SOLVED: To provide an inexpensive water-dispersion type preparation containing plant sterol comprising an emulsifier, dissolving plant sterol which is not dissolved in water at all and has extremely high crystallinity and thereby hardly dissolves also in oil, causing no precipitation of plant sterol crystals even when long preserved, and having no specific unfancied taste and smell so as to be usable for food or drink. SOLUTION: The water-dispersion type preparation containing plant sterol is formulated with plant sterol and diglycerol fatty acid ester at a specific ratio to prevent precipitation of plant sterol crystals even when long preserved, incorporated with a decaglycerol fatty acid ester to stably disperse in water for a long time, and formulated with a polyhydric alcohol to provide emulsion stability of an original body itself so as not to cause deterioration in the plant sterol and perform uniform and stable emulsification and dispersion in water for a long period of time. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：提供一种廉价的含有乳化剂的植物甾醇的水分散型制剂，其溶解植物甾醇，其根本不溶于水，具有极高的结晶度，因此也难以溶解在油中，不产生 植物甾醇晶体的沉淀，即使长时间保存，并且没有特定的不合适的味道和气味，以便可用于食品或饮料。 解决方案：含有植物甾醇的水分散型制剂以特定比例与植物甾醇和二甘油脂肪酸酯配制，以防止植物甾醇晶体沉淀，即使长时间保存，加入十甘油脂肪酸酯稳定分散 在水中长时间配制，并用多元醇配制，以提供原体本身的乳液稳定性，以免使植物甾醇变质，并长时间均匀稳定地乳化和分散在水中。 版权所有（C）2005，JPO＆NCIPI

    Purification of stevioside
    5.
    发明专利
    Purification of stevioside 失效
    维生素D的纯化

    公开(公告)号：JPS5775992A

    公开(公告)日：1982-05-12

    申请号：JP15281980

    申请日：1980-10-30

    申请人： Tama Seikagaku Kk

    发明人： OSADA MASASHI ,  YAMAMOTO TADASHI

    IPC分类号： C07G99/00 ,  C07H1/08 ,  C07H15/256

    摘要： PURPOSE: To carry out the decoloring and purification of stevioside, easily, in an industrial scale, by treating the extract liquid of the leaves of Stevia with activated charcoal and activated clay in combination, thereby effectively removing the impurities such as pigments from the liquid.
    CONSTITUTION: The extract liquid obtained by the extraction of the sweetening substances (general name: stevioside) from the leaves of Stevia rebaudiana Bertoni, is mixed with a flocculant (e.g. common alum or polyaluminum chloride) to flocculate and remove the collidal impurities, and then treated with a non-polar resin (e.g. "Duolite " ES-861) to adsorb the sweetening substance to said non-polar resin. The adsorbed substance is eluted with an organic solvent (e.g. methanol, acetone, etc.), and the eluate is decolored and purified with activated charcoal and activated clay. Although activated charcoal can absorb the stevioside firmly in an aqueous solution, it hardly adsorbs in an organic solvent and nevertheless keeps the decoloring effect. The decoloring and purification effects of activated charcoal can be promoted by the combined use with activated clay.
    COPYRIGHT: (C)1982,JPO&Japio

    摘要翻译： 目的：通过组合使用活性炭和活性粘土处理甜菊叶片的提取液，可以容易地以工业规模进行甜菊苷的脱色纯化，从而有效地从液体中除去颜料等杂质。 构成：将从甜叶菊甜叶菊叶中提取甜味物质（通称为甜菊苷）得到的提取液与絮凝剂（如普通明矾或聚氯化铝）混合，絮凝除去杂质，然后 用非极性树脂（例如“Duolite”ES-861）处理以将甜味物质吸附到所述非极性树脂上。 吸附的物质用有机溶剂（例如甲醇，丙酮等）洗脱，并将洗脱液脱色并用活性炭和活性粘土纯化。 虽然活性炭可以在水溶液中牢固地吸收甜菊苷，但它几乎不吸附在有机溶剂中，但仍然保持消色效果。 通过与活性粘土的组合使用可以促进活性炭的脱色和净化效果。

    Oil and fat composition of plant sterol ester
    6.
    发明专利
    Oil and fat composition of plant sterol ester 审中-公开
    植物甾醇酯的油和脂肪组成

    公开(公告)号：JP2011024464A

    公开(公告)日：2011-02-10

    申请号：JP2009172406

    申请日：2009-07-23

    申请人： Tama Seikagaku Kk ,  タマ生化学株式会社

    发明人： KATAHIRA RYOTA ,  HATAKE SHUICHI ,  MAKINO TAKAO

    IPC分类号： A21D2/14 ,  A21D13/00 ,  A21D13/08

    摘要： PROBLEM TO BE SOLVED: To provide a food such as breads or cakes having a high content of a plant sterol having lipid metabolism-ameliorating activity such as calorie-reducing or cholesterol-reducing activities by using no fat but by utilizing a plant sterol ester preparation itself as a food as a substitute of oils and fats such as shortening or margarine.
    SOLUTION: The plant sterol ester is used as the substitute of a fat and oil composition such as the shortening or margarine in the production of the breads or cakes.
    COPYRIGHT: (C)2011,JPO&INPIT

    摘要翻译： 要解决的问题：提供具有高含量植物甾醇的食物，例如具有脂质代谢改善活性如减少热量或减少胆固醇的活性的食物，其不使用脂肪而是利用植物 甾醇酯制剂本身作为食物作为油脂的代用品，如起酥油或人造黄油。 解决方案：在生产面包或蛋糕时，使用植物甾醇酯作为脂肪和油组合物的替代物，例如起酥油或人造黄油。 版权所有（C）2011，JPO＆INPIT

    Composition suitable for producing pill
    9.
    发明专利
    Composition suitable for producing pill 审中-公开
    适用于生产药丸的组合物

    公开(公告)号：JP2007097464A

    公开(公告)日：2007-04-19

    申请号：JP2005291036

    申请日：2005-10-04

    申请人： Kobata Sogo Kenkyusho:Kk ,  Tama Seikagaku Kk ,  タマ生化学株式会社 ,  有限会社コバタ総合研究所

    发明人： OBATA TAKAJI ,  WAKAYAMA TSUNEO ,  HATAKE SHUICHI

    IPC分类号： A23L1/30

    摘要： PROBLEM TO BE SOLVED: To provide a composition suitable for producing pills with which pills highly containing plant sterol having specific waxen property is produced. SOLUTION: The composition suitable for producing pills is obtained by using rice flour as raw material almost serving as base material suitable for producing pills comprising plant sterol. Namely, the food composition for producing pills comprises 35-80 wt.% of rice flour and raw material almost serving as an adhesive based on 20-55 wt.% of the plant sterol. COPYRIGHT: (C)2007,JPO&INPIT

    摘要翻译： 要解决的问题：提供适合于制备丸剂的组合物，其中制备了高度含有具有特定蜡质特性的植物甾醇的丸剂。 解决方案：适用于生产丸剂的组合物通过使用米粉作为几乎用作生产包含植物甾醇的丸剂的基础材料的原料获得。 即，用于生产丸剂的食品组合物包含35-80重量％的米粉和基于20-55重量％的植物甾醇几乎用作粘合剂的原料。 版权所有（C）2007，JPO＆INPIT