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    Antibody enzyme against the n-terminal region of the chemokine receptor ccr5
    7.
    发明专利
    Antibody enzyme against the n-terminal region of the chemokine receptor ccr5 有权

    公开(公告)号：JP4777785B2

    公开(公告)日：2011-09-21

    申请号：JP2006023638

    申请日：2006-01-31

    Applicant: 独立行政法人科学技術振興機構

    Inventor： 恵美 一二三 ,  泰三 宇田 ,  好子 岡村

    IPC: C12N9/50 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09

    Abstract: PROBLEM TO BE SOLVED: To provide an antibody enzyme eliminating the function of a chemokine receptor CCR which is a coreceptor of an AIDS virus by degrading the chemokine receptor CCR5, and utilized for preventing the infection with the AIDS virus or treating the AIDS; and to provide an anti-HIV medicament utilizing the antibody enzyme. SOLUTION: A monoclonal antibody is produced by using a peptide constituting the N-terminal region of the chemokine receptor CCR5 as an immunogen, and amino acid sequences and base sequences of variable regions of the heavy chain and the light chain of the monoclonal antibody are determined. The three-dimensional structure is estimated and the presence or absence of a triadic structure of catalyst residues is confirmed by carrying out molecular modeling as the amino acid sequence. Finally, it is found that the variable region of the light chain of the monoclonal antibody (5A2, 6A2, 2B8) having the triadic structure of the catalyst residues functions as the antibody enzyme. COPYRIGHT: (C)2007,JPO&INPIT

    Peptides and their use to control the dissolution of the thrombus
    9.
    发明专利
    Peptides and their use to control the dissolution of the thrombus 有权

    公开(公告)号：JP4149208B2

    公开(公告)日：2008-09-10

    申请号：JP2002206225

    申请日：2002-07-15

    Applicant: 独立行政法人科学技術振興機構

    Inventor： 恵美 一二三 ,  俊孝 堀内 ,  泰三 宇田 ,  學 山田

    IPC: C12N15/09 ,  G01N33/50 ,  A61K38/55 ,  A61P7/02 ,  A61P43/00 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  G01N33/15 ,  G01N33/53

    Abstract: PROBLEM TO BE SOLVED: To provide a peptide for regulating thrombolysis and to provide a method for utilizing the same. SOLUTION: The peptide for regulating the thrombolysis is one of the following (a) to (d): (a) a polypeptide comprising an amino acid sequence derived from a bovine hemoglobin β-chain, and having a function of enhancing plasmin activities; (b) a polypeptide comprising an amino acid sequence having one or more substituted, deleted, inserted and/or added amino acids in the amino acid sequence represented in (a), and having the function of enhancing the plasmin activities; (c) a polypeptide comprising an amino acid sequence derived from the bovine hemoglobin β-chain, and having a function of inhibiting the plasmin activities; and (d) a polypeptide comprising an amino acid sequence having one or more substituted, deleted, inserted and/or added amino acids in the amino acid sequence represented in (c), and having the function of inhibiting the plasmin activities. COPYRIGHT: (C)2004,JPO

    抗がん剤
    10.
    发明专利
    抗がん剤 有权
    抗癌药

    公开(公告)号：JPWO2013133253A1

    公开(公告)日：2015-07-30

    申请号：JP2013544897

    申请日：2013-03-05

    Applicant: 独立行政法人科学技術振興機構

    Inventor： 宇田　泰三 ,  泰三 宇田 ,  一二三　恵美 ,  恵美 一二三

    IPC: A61K39/395 ,  A61P11/00 ,  A61P35/00 ,  C07K16/18 ,  C12N15/09

    CPC classification number: C07K16/3023 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/515 ,  C07K2317/60 ,  C07K2317/73

    Abstract: 本発明により、がん細胞、特に肺がん細胞に対して細胞障害性を示すヒト型抗体軽鎖を有効成分とする抗がん剤が提供される。本発明の抗がん剤は主に、可変領域が配列番号1、9、若しくは13のアミノ酸配列、又はこれらのアミノ酸配列において1若しくは数個のアミノ酸が置換、付加、若しくは欠失したアミノ酸配列によって示されるポリペプチドからなり、二量体であるヒト抗体&kgr;型軽鎖、又は可変領域が配列番号19のアミノ酸配列、又は当該アミノ酸配列において1若しくは数個のアミノ酸が置換、付加、若しくは欠失したアミノ酸配列によって示されるポリペプチドからなり、単量体であるヒト抗体&kgr;型軽鎖を含有することを特徴とする。

    Abstract translation: 提供了本发明，癌症细胞，特别是抗癌药，指示对抗肺癌细胞细胞毒性的人抗体轻链的活性成分。 本发明的抗癌剂是主要可变区SEQ ID NO：1,9，或13的氨基酸序列，或一个或几个氨基酸在这些氨基酸序列中取代，添加或缺失通过氨基酸序列 由表示的多肽，二聚体，其中人抗体KGR;型轻链，或可变区SEQ ID NO的氨基酸序列：19，或一个或在氨基酸序列的几个氨基酸，添加或删除 包括由氨基酸序列，人抗体＆KGR所示多肽是单体;其特征在于它包含一个类型的轻链。

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