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    SULFONAMIDE DERIVATIVE
    5.
    发明专利
    SULFONAMIDE DERIVATIVE 失效

    公开(公告)号：JPS5718662A

    公开(公告)日：1982-01-30

    申请号：JP7817081

    申请日：1981-05-25

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： ANTON MENTORUUPU ,  KURUTO SHIYUROMU ,  ERUNSUTO OTSUTOO RENTO ,  BERUNAA TORAUNETSUKAA

    IPC分类号： A61K31/18 ,  A61P9/00 ,  A61P9/08 ,  A61P11/08 ,  C07C67/00 ,  C07C301/00 ,  C07C303/34 ,  C07C307/10 ,  C07D207/40 ,  C07D295/22 ,  C07D295/26 ,  C07D473/08

    摘要： Title cpds. of formula (I):- (where R1 is H or lower alkyl and R2 is lower alkyl, or R1+R2 is -(CH2)1-5-; R3 is H or OH. R4 is H, Me or Et; and R5 is H or alkyl opt. substd. by a heterocyclic residue or is an aralkyl or aryloxyalkyl gp. in which the aryl moiety is opt. substd.), in the form of the racemates, diastereomeric racemates or optical antipodes, and their acid addn. salts, have peripheral vasodilatory activity and effects on blood pressure, and also increase cardiac efficiency (without increasing heart rate) and as broncholytic agents. (I) are also inters. for pharmaceuticals. They are pref. prepd. by removing the protecting gps. from a corresp. cpd. in which the omega-amino gp. is protected by a hydro(geno)lytically removable gp. and/or the phenolic OH gp. is protected by a gp. which is removable hydro(geno)lyticall, by re-esterificn. of by means of ether-eliminating agents.

    SULFONAMIDE COMPOUND
    6.
    发明专利
    SULFONAMIDE COMPOUND 失效

    公开(公告)号：JPS5718660A

    公开(公告)日：1982-01-30

    申请号：JP7816981

    申请日：1981-05-25

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： ANTON MENTORUUPU ,  KURUTO SHIYUROMU ,  ERUNSUTO OTSUTOO RENTO ,  BERUNAA TORAUNETSUKAA

    IPC分类号： A61K31/18 ,  A61P9/00 ,  A61P9/08 ,  A61P11/08 ,  C07C67/00 ,  C07C301/00 ,  C07C303/34 ,  C07C307/10 ,  C07D207/40 ,  C07D295/22 ,  C07D295/26 ,  C07D473/08

    摘要： Title cpds. of formula (I):- (where R1 is H or lower alkyl and R2 is lower alkyl, or R1+R2 is -(CH2)1-5-; R3 is H or OH. R4 is H, Me or Et; and R5 is H or alkyl opt. substd. by a heterocyclic residue or is an aralkyl or aryloxyalkyl gp. in which the aryl moiety is opt. substd.), in the form of the racemates, diastereomeric racemates or optical antipodes, and their acid addn. salts, have peripheral vasodilatory activity and effects on blood pressure, and also increase cardiac efficiency (without increasing heart rate) and as broncholytic agents. (I) are also inters. for pharmaceuticals. They are pref. prepd. by removing the protecting gps. from a corresp. cpd. in which the omega-amino gp. is protected by a hydro(geno)lytically removable gp. and/or the phenolic OH gp. is protected by a gp. which is removable hydro(geno)lyticall, by re-esterificn. of by means of ether-eliminating agents.